Category: 200064-11-5

Synthetic Route of 200064-11-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 200064-11-5, name is 4-(5-Bromo-2-pyridyl)morpholine. A new synthetic method of this compound is introduced below.

Under the protection of nitrogen, CuI (1 mmol), Cs2CO3 (20 mmol) and ethyl 2-oxocyclohexylcarboxylate (2 mmol) were added to DMSO (10 mL).Stir at room temperature for 30 min.5-hydroxy-3-methoxy-4-phenylquinolin-2(1H)-one (10 mmol) and 4-(5-bromopyridin-2-yl)morpholine (10 mmol) in DMSO (12 mL) solution, added by injection.Heat to 100 C overnight. Cool to room temperature, filter, add water (50 mL) and dichloromethane (50 mL×3) and collect organics.The solvent was evaporated under reduced pressure, and the crude material was purified by column chromatography to give 5-hydroxy-3-methoxy-1-(6-morpholinylpyridin-3-yl)-4-phenylquinolin-2 (1H) -ketone.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,200064-11-5, its application will become more common.

Reference:
Patent; Ocean University of China; Shao Changlun; (69 pag.)CN108658937; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 200064-11-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 200064-11-5, name is 4-(5-Bromo-2-pyridyl)morpholine. A new synthetic method of this compound is introduced below.

Under the protection of nitrogen, CuI (1 mmol), Cs2CO3 (20 mmol) and ethyl 2-oxocyclohexylcarboxylate (2 mmol) were added to DMSO (10 mL).Stir at room temperature for 30 min.5-hydroxy-3-methoxy-4-phenylquinolin-2(1H)-one (10 mmol) and 4-(5-bromopyridin-2-yl)morpholine (10 mmol) in DMSO (12 mL) solution, added by injection.Heat to 100 C overnight. Cool to room temperature, filter, add water (50 mL) and dichloromethane (50 mL×3) and collect organics.The solvent was evaporated under reduced pressure, and the crude material was purified by column chromatography to give 5-hydroxy-3-methoxy-1-(6-morpholinylpyridin-3-yl)-4-phenylquinolin-2 (1H) -ketone.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,200064-11-5, its application will become more common.

Reference:
Patent; Ocean University of China; Shao Changlun; (69 pag.)CN108658937; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 200064-11-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 200064-11-5, name is 4-(5-Bromo-2-pyridyl)morpholine, molecular formula is C9H11BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirred solution of the title compound of Preparative Example 1 (0.150 g, 1 eq) in dry 1 ,4- dioxane (5 mL) was added the commercially available 4-(6-bromobenzo[d]thiazoI-2- yl)morpholine (1 eq), sodium tert-butoxide (3 eq) and the mixture was degassed for 10 minutes under N2 atmosphere. To this reaction mixture was added Pd2(dba)3 (0.05 eq) and Ru-Phos (0.1 eq) and the mixture was heated to 100C until the completion of the reaction. After the completion of the reaction, the reaction mixture was filtered through a celite bed, and washed with EtOAc. The filtrate was concentrated and the crude product was purified by column chromatography or preparative HPLC to afford title compound 6 as indicated in table 2.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 200064-11-5, 4-(5-Bromo-2-pyridyl)morpholine.

Reference:
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem