Category: 2002-04-2

Application of 2002-04-2, Adding some certain compound to certain chemical reactions, such as: 2002-04-2, name is 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine,molecular formula is C7H6N4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-04-2.

General procedure: 2-Amino-5-(4-pyridinyl)-1,3,4-thiadiazole (0.057 g, 0.32 mmol) was mixed with 3,4-dichlorophenyl isocyanate (0.050 g, 0.027 mmol), dissolved in DMF (1 mL), and heated at 90C for 30 min. The mixture was allowed to cool before quenching with DI water (1 mL) to yield a precipitate.

According to the analysis of related databases, 2002-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rosenthal, Andrew S.; Dexheimer, Thomas S.; Gileadi, Opher; Nguyen, Giang H.; Chu, Wai Kit; Hickson, Ian D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 20; (2013); p. 5660 – 5666;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 2002-04-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2002-04-2, name is 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine, molecular formula is C7H6N4S, molecular weight is 178.21, as common compound, the synthetic route is as follows.

General procedure: An equimolar amount of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine (3c) dissolve in 10-15mL of tetrahydrofuran (THF), add 2-3 drops of triethylamine, to this solution add 1.5mol different aryl chlorides gradually, continuous stirring for 3h on ice bath(0C). After completion of reaction solid will precipitate out, washed with sodium bicarbonate solution to remove excess of chloride and recrystallized from ethanol to get pure compound.

The chemical industry reduces the impact on the environment during synthesis 2002-04-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Patel, Harun; Jadhav, Harsha; Ansari, Iqrar; Pawara, Rahul; Surana, Sanjay; European Journal of Medicinal Chemistry; vol. 167; (2019); p. 1 – 9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2002-04-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2002-04-2, name is 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine, molecular formula is C7H6N4S, molecular weight is 178.21, as common compound, the synthetic route is as follows.

General procedure: An equimolar amount of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine (3c) dissolve in 10-15mL of tetrahydrofuran (THF), add 2-3 drops of triethylamine, to this solution add 1.5mol different aryl chlorides gradually, continuous stirring for 3h on ice bath(0C). After completion of reaction solid will precipitate out, washed with sodium bicarbonate solution to remove excess of chloride and recrystallized from ethanol to get pure compound.

The chemical industry reduces the impact on the environment during synthesis 2002-04-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Patel, Harun; Jadhav, Harsha; Ansari, Iqrar; Pawara, Rahul; Surana, Sanjay; European Journal of Medicinal Chemistry; vol. 167; (2019); p. 1 – 9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 2002-04-2, 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H6N4S, blongs to pyridine-derivatives compound. HPLC of Formula: C7H6N4S

General procedure: 2-Amino-5-(4-pyridinyl)-1,3,4-thiadiazole (0.057 g, 0.32 mmol) was mixed with 3,4-dichlorophenyl isocyanate (0.050 g, 0.027 mmol), dissolved in DMF (1 mL), and heated at 90C for 30 min. The mixture was allowed to cool before quenching with DI water (1 mL) to yield a precipitate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2002-04-2, 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine, and friends who are interested can also refer to it.

Reference:
Article; Rosenthal, Andrew S.; Dexheimer, Thomas S.; Gileadi, Opher; Nguyen, Giang H.; Chu, Wai Kit; Hickson, Ian D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 20; (2013); p. 5660 – 5666;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 2002-04-2, 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2002-04-2, blongs to pyridine-derivatives compound. name: 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine

A solution of (i?)-3-methoxy-4-(l-phenyl-2-((triisopropylsilyl)oxy)ethoxy)benzoic acid (0.1.0 g, 2.2 mmol, 1 eq.), 5-(4-pyridyl)-l,3,4-thiadiazol-2-yl amine (0.467g, 2.6 mmol, 1.2 eq.), HATU (1.35 g, 3.5 mmol, 1.5 eq.) and diisopropylethylamine (480 mu^, 2.75 mmol, 1.2 eq.) in NMP (10 mL) was stirred at 70 C for 16 hours. The cooled reaction mixture was added to water (100 mL) and the crude product filtered and partitioned between dichloromethane (100 mL) and water (15 mL). The layers were separated and the aqueous extracted with a mixture of dichloromethane (100 mL) and methanol (10 mL). The combined extracts were dried with magnesium sulfate, evaporated in vacuo and purified by silica gel column chromatography using a 20 – 100 % ethyl acetate in iso- exane gradient to afford (R)-3 -methoxy-4-(l -phenyl-2-((triisopropylsilyl)oxy)ethoxy)-N-(5-(pyridin-4-yl)- l,3,4-thiadiazol-2-yl)benzamide as a white solid (0.784 g, 60% yield). NMR (400 MHz, DMSO) 13.16 (IH, s), 8.79 (2H, dd, J=1.6, 4.5 Hz), 7.99 (2H, dd, J=1.6, 4.4 Hz), 7.84 (IH, d, J=2.0 Hz), 7.68 (IH, dd, J=2.1, 8.6 Hz), 7.52 – 7.48 (2H, m), 7.40 (2H, dd, J=7.6, 7.6 Hz), 7.37 – 7.32 (IH, m), 7.09 (IH, d, J=8.9 Hz), 5.62 (IH, dd, J=4.5, 6.5 Hz), 4.14 (IH, dd, J=6.8, 10.6 Hz), 4.00 (IH, dd, J=4.5, 10.8 Hz), 3.97 (3H, s), 1.15 – 1.08 (3H, m), 1.07 – 1.02 (18H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2002-04-2, its application will become more common.

Reference:
Patent; GENKYOTEX SA; MACHIN, Peter; SHARPE, Andrew; LOCK, Christopher James; CHAMBERS, Mark S; HODGES, Alastair; ALLEN, Vivienne; ELLARD, John M; (189 pag.)WO2016/98005; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 2002-04-2 ,Some common heterocyclic compound, 2002-04-2, molecular formula is C7H6N4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of (Patent; GENKYOTEX SA; MACHIN, Peter; SHARPE, Andrew; LOCK, Christopher James; CHAMBERS, Mark S; HODGES, Alastair; ALLEN, Vivienne; ELLARD, John M; (189 pag.)WO2016/98005; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem