Category: 20173-24-4

Related Products of 20173-24-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20173-24-4, name is 2-(Pyridin-3-yl)ethanamine, molecular formula is C7H10N2, molecular weight is 122.1677, as common compound, the synthetic route is as follows.

To a solution of 2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]acetaldehyde (50 mg, 0.19 mmole), 5 mL DCM and NA2S04 (134 mg, 0.95 mmole) was added 2-(pyridin-3- yl)ethan-l -amine (31 mg, 0.25 mmole) and the reaction was stirred overnight. NaBH4 (9.5 mg, 0.25 mmole) added, stir 10 minutes, 2 drops MeOH added, stir lh, quenched with water, organics separated off and evaporated. The residue was passed through a Gilson reverse phase HPLC to give {2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9- yl]ethyl}[2-(pyridin-3-yl)ethyl]amine, 65.3 mg (71%). LCMS m/z 367.1 (M + 1) observed

The chemical industry reduces the impact on the environment during synthesis 20173-24-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TREVENA, INC.; VIOLIN, Jonathan D.; SOERGEL, David G.; (177 pag.)WO2017/106547; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 20173-24-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20173-24-4, name is 2-(Pyridin-3-yl)ethanamine, molecular formula is C7H10N2, molecular weight is 122.1677, as common compound, the synthetic route is as follows.

Reference Example 19 (4-Chloro-6-morpholin-4-yl-pyrimidin-2-yl)-(2-pyridin-3-yl-ethvD-amine; 4-(2,6-Dichloro-pyrimidin-4-yl)-moipholine was prepared as described inWO2006/060194.To a stirred solution of 4-(2,6-dichloro-pyrimidin-4-yl)-morpholine (936 mg; 4.0 mmol) and DIPEA (0.77 ml; 4.4 mmol) in dioxane (10 ml) at 5C was added 3-(2- aminoethyl)pyridine (0.53 ml; 4.4 mmol). The cooling bath was removed and the reaction mixture stirred at r.t. for 5 h then heated at 70C for 40 h. Volatiles were removed in vacuo and the residue purified by flash chromatography (95:5 EtOAc/MeOH as eluent) to afford the title compound as a white crystalline solid (963 mg; 75 %). deltaH (400 MHz, CDCl3) 2.91 (t, J = 7.2, 2H), 3.57 (t, J = 4.8, 4H), 3.66 (q, J = 7.2, 2H), 3.77 (t, J = 4.8, 4H), 5.00 (br s, IH), 5.90 (s, IH), 7.24 (dd, J = 7.6 and 4.8, IH), 7.55 (d, J = 7.6, IH), 8.49-8.51 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 20173-24-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125839; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 20173-24-4 ,Some common heterocyclic compound, 20173-24-4, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3.1 g (?3.5 mmol) PS-carbodiimide was added to a solution of 244 mg (2.0 mmol) 2-(pyridine-3-yl)ethylamine and 542 mg (3.0 mmol) 3-(3-chlorophenyl)-propiolic acid in DCM (50 ml) and the reaction solution was shaken for 16 h at RT. The resin was subsequently filtered off and rinsed with DCM and MeOH. The filtrate was concentrated in a vacuum and CC(CHCl3/MeOH 40:1) was performed with the residue, whereby 447 mg (1.6 mmol, 80%) 3-(3-chlorophenyl)-N-(2-(pyridine-3-yl)ethyl)propiolamide was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20173-24-4, 2-(Pyridin-3-yl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUNENTHAL GMBH; US2009/182020; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20173-24-4, name is 2-(Pyridin-3-yl)ethanamine, the common compound, a new synthetic route is introduced below. Safety of 2-(Pyridin-3-yl)ethanamine

1-(1-(4-chlorobenzyl)-1H-indole-2-carbonyl)piperidine-4-carboxylic acid (300 mg, 0.756 mmol), 1-hydroxybenzotriazole (170 mg, 1.261 mmol), EDCI (242 mg, 1.261 mmol) were dissolved in DCM (Ratio: 4.00, Volume: 4.0 ml). the reaction was allowed to stir at room temperature for 10 minutes before adding Hunig’sBase (0.330 ml, 1.891 mmol) and a DMF (Ratio: 1.000, Volume: 1 ml) solution of 2-(pyridin-3-yl)ethanamine, HCl (100 mg, 0.630 mmol). The reaction was stirred overnight. The reaction was diluted with water and ethyl acetate. The organic layer was washed with saturated sodium bicarbonate, 10% aqeuous citric acid solution, followed by saturated sodium chloride solution. The organic layer was dried over magnesium sulfate, filtered and concentrated. The resulting solid was triturated with ethyl acetate to obtain white solid as a product. 1H-NMR (400 MHz, DMSO-d6) 8.40, 7.88, 7.66-7.57, 7.54, 7.36-7.27, 7.20, 7.16-7.04, 6.71, 5.48, 4.56-3.80, 3.32-3.25, 2.89, 2.73, 2.38-2.27, 1.47

The synthetic route of 20173-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; US2012/252807; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20173-24-4, name is 2-(Pyridin-3-yl)ethanamine, the common compound, a new synthetic route is introduced below. SDS of cas: 20173-24-4

General procedure: A microwave tube was charged with 6′-bromo-8′-chloro-2’H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione 3 (1.00 eq.), amine (1.00 eq.), Cs2CO3 (2.00 eq.), Pd2(dba)3 (0.10 eq.), xantphos (0.10 eq.) and 1,4-dioxane (4 mL). The reaction mixture was heated under microwave irradiation at 130 C for 30 min, concentrated under reduced pressure, and purified by flash column chromatography (silica gel, DCM ramping to DCM/CH3OH = 9:1) to yield the desired product.

The synthetic route of 20173-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Abdelaziz, Ahmed M.; Basnet, Sunita K.C.; Islam, Saiful; Li, Manjun; Tadesse, Solomon; Albrecht, Hugo; Gerber, Cobus; Yu, Mingfeng; Wang, Shudong; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2650 – 2654;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 20173-24-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20173-24-4, name is 2-(Pyridin-3-yl)ethanamine, molecular formula is C7H10N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 157: 3-Fluoro-8-isopropyl-11 -oxo-/V-(2-pyridin-3-ylethyl)-10,11 – dihydrodibenzo[6,/][1 ,4]thiazepine-7-sulfonamide 5,5-dioxide [0487] Triethylamine (0.173 g, 1.71 mmol) and 3-(2-aminoethyl)pyridine (0.114 g, 0.930 mmol) were dissolved in dichloromethane (5 ml_), and 3-fluoro-8-isopropyl-5,5- dioxido-11-oxo-10,11-dihydrodibenzo[6,r][1 ,4]thiazepine-7-sulfonyl chloride (6.25 ml_ of 0.124 M solution, 0.775 mmol) was added as a solution in dichloromethane. The mixture was stirred 16 hours at room temperature, then poured into dilute hydrochloric acid. The aqueous layer was extracted twice with dichloromethane, and the combined organic layers were dried over magnesium sulfate and concentrated to afford a brown oil, which was purified by silica gel column chromatography (hexane/ethyl acetate/methanol, 90/9/1 to 0/90/10) to afford 3-fluoro-8-isopropyl-11- oxo-/V-(2-pyridin-3-ylethyl)-10, 11 -dihydrodibenzo[6, /][1 ,4]thiazepine-7-sulfonamide 5,5-dioxide (0.050 g) as a white solid.MS (ES) m/z 503.8;HPLC purity 95.5% at 210-370 nm, 8.5 minutes.; Xterra RP 18, 3.5u, 150 x 4.6 mm column, 1.2 mL/min, 85/15-5/95 (Ammon. Form. Buff. Ph=3.5/ACN+MeOH) for 10 minutes, hold 4 minutes.HRMS: calculated for C23H22FN3O5S2 + H+, 504.10577; found (ESI1 [M+H]+), 504.1046;

According to the analysis of related databases, 20173-24-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WYETH; WO2008/61029; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem