Category: 20265-37-6

Related Products of 20265-37-6 ,Some common heterocyclic compound, 20265-37-6, molecular formula is C6H6N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Methoxy-2-nitro-pyridine (53, 7.00 g, 45.4 mmol) in 100 mL of methanol, was degassed and palladium (0.7 g, 20%) was added. The reaction was stirred at room temperature for one day under a hydrogen balloon. The reaction was filtered through celite and the filtrate concentrated under vacuum to provide the desired compound (54, 5.555 g). MS (ESI) [M+H+]+=125.3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20265-37-6, 3-Methoxy-2-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Plexxikon Inc.; Zhang, Jiazhong; Ibrahim, Prabha N.; Bremer, Ryan; Spevak, Wayne; Cho, Hanna; US9096593; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20265-37-6, name is 3-Methoxy-2-nitropyridine, molecular formula is C6H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

Step 2: A mixture of compound 32-2 (3.2 g, 20.6 mmol), Fe (5.8 g, 130.2 mmol) and AcOH (30 mL) was stirred at room temperature for lh. The mixture was filtered and to the filtrate was added Py HBr Br2. The reaction stirred at room temperature overnight. Solvent was evaporated and the residue diluted with CH3OH. The mixture was basified to pH 7 with NaHCC>3 and evaporated. The residue was purified by column chromatography (eluent: PE/EA = 2/1) to give 32-3 as a yellow oil. LC-MS: m/z = 203.0 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 20265-37-6.

Reference:
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20265-37-6, name is 3-Methoxy-2-nitropyridine, molecular formula is C6H6N2O3, molecular weight is 154.12, as common compound, the synthetic route is as follows.Recommanded Product: 3-Methoxy-2-nitropyridine

In a round bottom flask potassium tertiary butoxide (146 mg, 1.297 mmol) was taken under nitrogen atmosphere, anhydrous dimethylformamide (3 mL) was added and stirred at room temperature for 10 min. Then cooled to -40 C and 2-nitro-3-methoxypyridine(100 mg, 0.648 mmol) was added followed by dropwise addition of 2-chloro-propionic acid ethyl ester (0.0908 mL, 0.712 mmol) and stirred for 20 min. Then dilute HCI was added and stirred at room temperature for 10 min. Extracted in ethyl acetate, washed with water, dried over MgS0 , filtered and solvent was evaporated and finally purified by column chromatography to afford 2-(5-methoxy-6-nitro-pyridin-3-yl)-propionic acid ethyl ester (82 mg, 50%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20265-37-6, 3-Methoxy-2-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2013/13817; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 20265-37-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20265-37-6, name is 3-Methoxy-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

The compound forms a neutral fumarate, which after recrystallisation from a mixture of isopropanol and acetone melts, as the hydrate, at 124-126. The starting material can be prepared as follows: 26.5 g of sodium hydride are added in the course of one hour to a mixture of 161 g of 3-methoxy-2-nitropyridine and 144 g of 2,2-dimethyl-5-hydroxymethyl-1,3-dioxolane in 1,000 ml of hexamethylphosphoric acid triamide, with stirring; by means of cooling, the temperature is kept at 0-10 during the addition. The reaction mixture is then stirred for a further 5 hours with ice-cooling and then for 15 hours at room temperature. The reaction mixture is poured onto ice and extracted with diethyl ether. The organic extract is washed with a concentrated aqueous solution of sodium chloride, dried and evaporated. The residue is dissolved in 1,000 ml of ethanol, 100 ml of 2 N hydrochloric acid are added and the mixture is left to stand for 8 hours. After evaporating off the solvent, the residue is rendered alkaline with a concentrated solution of sodium hydroxide in water and extracted with ethyl acetate. Evaporating off the solvent yields a crude product from which crystalline 3-(3-methoxy-2-pyridyloxy)-1,2-propanediol with a melting point of 62-65 is obtained on the addition of diethyl ether.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20265-37-6, 3-Methoxy-2-nitropyridine.

Reference:
Patent; Ciba-Geigy Corporation; US4264599; (1981); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 20265-37-6 ,Some common heterocyclic compound, 20265-37-6, molecular formula is C6H6N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

As shown in step 6-i of Scheme 6, calcium chloride (4.0 g, 35.7 mmol) was added to a stirring solution of 3-methoxy-2-nitropyridine (5.0 g, 32.5 mmol, obtained from AK Scientific, Inc.) in methanol (100 mL) and water (25 mL). The reaction mixture was warmed to 75 0C and iron powder (4.6 g, 81.1 mmol) was added carefully over 10 min. The resulting reaction mixture was stirred at 75 0C for another 2 h. The reaction mixture was cooled to RT and filtered through a pad of diatomaceous earth. The pad was rinsed with ethanol (400 mL) and the filtrate was evaporated under reduced pressure. The residue was suspended in ethyl acetate/water (1/1, 200 mL), the organic layer was separated, and the aqueous layer was extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were washed with brine (60 mL), dried over Na2SO4, and concentrated under reduced pressure to afford 2- amino-3-methoxypyridine (Compound 1018, 3.6 g, 89 % yield): ESMS (M+H) 125; 1H NMR (DMSO-de) delta 7.5 (d, IH), 7.0 (d, IH), 6.5 (dd, IH), 5.6 (br, 2H), 3.75 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20265-37-6, its application will become more common.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon; COTTRELL, Kevin; GREY, Ronald; LE TIRAN, Amaud; MARONE, Valerie; MARTINEZ-BOTELLA, Gabriel; MESSERSMITH, David; HUCK, Emilie, Porter; WO2010/135014; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 20265-37-6, Adding some certain compound to certain chemical reactions, such as: 20265-37-6, name is 3-Methoxy-2-nitropyridine,molecular formula is C6H6N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20265-37-6.

EXAMPLE 9 1-hydroxy-7-aza-1H-indazole A solution of Na2 CO3 0.10 H2 O (7.3 mmol) in H2 O (10 ml) is emulsified under vigorous stirring at about room temperature or slightly elevated temperature with a solution of 2-nitro-3-methoxypyridine (4.25 mmol) and tetrabutylammonium bromide (10.06 mmol) as phase transfer catalyst in methylene chloride (~20mL). 2-phenyl-5(4H)-oxazolone (~60 mmol) is added in several portions during one hour. The layers are separated and the aqueous phase is washed with CH2 Cl2. The combined organic solutions are dried with Na2 SO4 and is evaporated under reduced pressure. The residue is chromatographed in silica gel starting with petroleum ether to which methylene chloride is gradually added. After recrystallizing, the complex is placed in refluxing methanol to which a catalytic amount of p-toluene sulfonic acid has been added. The sample is refluxed overnight. After cooling and evaporation of the solvent, the above-identified product is isolated.

According to the analysis of related databases, 20265-37-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Research Corporation Technologies, Inc.; US5580981; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem