Category: 204378-41-6

Adding a certain compound to certain chemical reactions, such as: 204378-41-6, Methyl 6-chloro-4-methoxypicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

(2) Synthesis of 6-chloro-4-methoxypicolinic Acid [Compound (II-75)] Using 6-chloro-4-methoxypicolinic acid methyl ester [Compound (V-75)] (0.5 g, 2.48 mmol), the Compound (II-75) was synthesised according to the process of Synthesis Example 20 (3). White solid, yield: 0.45 g, percent yield: 97.0percent, m.p.: 183-185° C. IR KBr cm-1: 1707, 1599, 1473, 1320, 1284, 1107, 1038, 921, 870, 723. 1H-NMR (60 MHz, d6-DMSO, delta): 3.84 (3H, s, OCH3), 6.94 (1H, d, J=2 Hz, pyridine ring H), 7.45 (1H, d, J=2 Hz, pyridine ring H), COOH indistinctness.

The synthetic route of 204378-41-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kureha Kagaku Kogyo K.K.; US6610853; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 204378-41-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 204378-41-6, name is Methyl 6-chloro-4-methoxypicolinate, molecular formula is C8H8ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(2) Synthesis of 6-chloro-4-methoxypicolinic Acid [Compound (II-75)] Using 6-chloro-4-methoxypicolinic acid methyl ester [Compound (V-75)] (0.5 g, 2.48 mmol), the Compound (II-75) was synthesised according to the process of Synthesis Example 20 (3). White solid, yield: 0.45 g, percent yield: 97.0%, m.p.: 183-185 C. IR KBr cm-1: 1707, 1599, 1473, 1320, 1284, 1107, 1038, 921, 870, 723. 1H-NMR (60 MHz, d6-DMSO, delta): 3.84 (3H, s, OCH3), 6.94 (1H, d, J=2 Hz, pyridine ring H), 7.45 (1H, d, J=2 Hz, pyridine ring H), COOH indistinctness.

According to the analysis of related databases, 204378-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kureha Kagaku Kogyo K.K.; US6610853; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 204378-41-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 204378-41-6, name is Methyl 6-chloro-4-methoxypicolinate, molecular formula is C8H8ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(2) Synthesis of 6-chloro-4-methoxypicolinic Acid [Compound (II-75)] Using 6-chloro-4-methoxypicolinic acid methyl ester [Compound (V-75)] (0.5 g, 2.48 mmol), the Compound (II-75) was synthesised according to the process of Synthesis Example 20 (3). White solid, yield: 0.45 g, percent yield: 97.0%, m.p.: 183-185 C. IR KBr cm-1: 1707, 1599, 1473, 1320, 1284, 1107, 1038, 921, 870, 723. 1H-NMR (60 MHz, d6-DMSO, delta): 3.84 (3H, s, OCH3), 6.94 (1H, d, J=2 Hz, pyridine ring H), 7.45 (1H, d, J=2 Hz, pyridine ring H), COOH indistinctness.

According to the analysis of related databases, 204378-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kureha Kagaku Kogyo K.K.; US6610853; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 204378-41-6 ,Some common heterocyclic compound, 204378-41-6, molecular formula is C8H8ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 6-chloro-4-methoxy-2-carboxylic acid methyl ester (2.63 g, 13.0 mmol) in dioxane (150 mL) is degassed and put under argon before Pd(dppf) (109 mg, 133 mumol) is added. To this mixture, 1-ethyl-propyl zink bromide (50 mL of a 0.5 M solution in THF, 25.0 mmol) is added dropwise. The mixture is stirred at 76°C for 15 h. The mixture is cooled to rt, diluted with water and extracted twice with EA. The combined org. extracts are dried over MgSO4, filtered and concentrated. The crude product is purified by MPLC on silica gel eluting with a gradient of EA in heptane to give 6-(1-ethyl-propyl)-4-methoxy-pyridine-2- carboxylic acid methyl ester (450 mg) as a pale yellow oil; LC-MS**: tR = 0.46 min; [M+1]+ = 238.34.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,204378-41-6, its application will become more common.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/109872; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 204378-41-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 204378-41-6, name is Methyl 6-chloro-4-methoxypicolinate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of methyl 6-chloro-4-methoxypicolinate 25 (500 mg, 2.48 mmol) and pentan-3-ylzinc(II) bromide (10 mL of a 0.5 M solution in THF) in dioxane (10 mL) Pd(dppf)Cl2 (21 mg, 25 mol) was added under argon. The mixture was stirred at 75°C for 18 h. The mixture was cooled the rt and the reaction was quenched by carefully adding water (10 mL). The mixture was filtered and the filtrate was extracted twice with EA (2×100 mL). The combined organic extracts were dried over MgSO4, filtered and concentrated. During the reaction the methyl picolinate was transformed to the pent-3-yl picolinate, and formation of the 6-(pent-2-yl)picolinate isomer complicated the purification and compromised the yield. Hence, the crude product was purified by CC on silica gel eluting with heptane:EA 9:1 to give pentan-3-yl 4-methoxy-6-(pentan-3-yl)picolinate 26 (145 mg, 20percent) as a pale yellow oil

According to the analysis of related databases, 204378-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bolli, Martin H.; Lescop, Cyrille; Birker, Magdalena; De Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Nayler, Oliver; Rey, Markus; Sieber, Patrick; Velker, Joerg; Weller, Thomas; Steiner, Beat; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 326 – 341;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 204378-41-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 204378-41-6, name is Methyl 6-chloro-4-methoxypicolinate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of methyl 6-chloro-4-methoxypicolinate 25 (600 mg, 2.98 mmol) and cyclopentylzinc bromide (12 mL of a 0.5 M solution in THF) in dioxane (10 mL) Pd(dppf)Cl2 (25 mg, 30 mol) was added. The mixture was stirred at 75°C for 18 h. The mixture was cooled the rt and the reaction was quenched by carefully adding water (20 mL). The mixture was filtered and the filtrate was extracted with EA (2×100 mL). The combined organic extracts were dried over MgSO4, filtered and concentrated. The crude product was purified by CC on silica gel eluting with heptane:EA 4:1 to give methyl 6-cyclopentyl-4-methoxypicolinate 30 (580 mg, ~80percent) as a pale yellow oil containing approx. 30percent of cyclopentyl 6-cyclopentyl-4-methoxypicolinate

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 204378-41-6, Methyl 6-chloro-4-methoxypicolinate.

Reference:
Article; Bolli, Martin H.; Lescop, Cyrille; Birker, Magdalena; De Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Nayler, Oliver; Rey, Markus; Sieber, Patrick; Velker, Joerg; Weller, Thomas; Steiner, Beat; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 326 – 341;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem