Category: 205676-84-2

Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic was written by Miller, William H.;Alberts, Doreen P.;Bhatnagar, Pradip K.;Bondinell, William E.;Callahan, James F.;Calvo, Raul R.;Cousins, Russell D.;Erhard, Karl F.;Heerding, Dirk A.;Keenan, Richard M.;Kwon, Chet;Manley, Peter J.;Newlander, Kenneth A.;Ross, Stephen T.;Samanen, James M.;Uzinskas, Irene N.;Venslavsky, Joseph W.;Yuan, Catherine C.-K.;Haltiwanger, R. Curtis;Gowen, Maxine;Hwang, Shing-Mei;James, Ian E.;Lark, Michael W.;Rieman, David J.;Stroup, George B.;Azzarano, Leonard M.;Salyers, Kevin L.;Smith, Brian R.;Ward, Keith W.;Johanson, Kyung O.;Huffman, William F.. And the article was included in Journal of Medicinal Chemistry in 2000.Application of 205676-84-2 This article mentions the following:

A new series of small mol. RGD mimetics that are highly potent, orally active 浼獀灏? antagonists is described. Selected members of this series are potent inhibitors of bone resorption in vitro and in vivo and have activity in an animal model of osteoporosis. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Application of 205676-84-2).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 205676-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation was written by Kroth, Heiko;Sreenivasachary, Nampally;Hamel, Anne;Benderitter, Pascal;Varisco, Yvan;Giriens, Valerie;Paganetti, Paolo;Froestl, Wolfgang;Pfeifer, Andrea;Muhs, Andreas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate This article mentions the following:

It is assumed that amyloid-β aggregation is a crucial event in the pathogenesis of Alzheimer’s disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the β-sheet conformation of Aβ via donor-acceptor-donor hydrogen bond formation. A series of pyridine derivatives, e.g., I•3HCl, were synthesized and tested regarding their potential to inhibit the aggregation of Aβ. The 2,6-diaminopyridine moiety was identified as a key component to inhibit Aβ aggregation. Overall, compounds having three 2,6-disubstituted pyridine units separated by at least one C2- or C3-linker displayed the most potent inhibition of Aβ aggregation. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation was written by Kroth, Heiko;Sreenivasachary, Nampally;Hamel, Anne;Benderitter, Pascal;Varisco, Yvan;Giriens, Valerie;Paganetti, Paolo;Froestl, Wolfgang;Pfeifer, Andrea;Muhs, Andreas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate This article mentions the following:

It is assumed that amyloid-β aggregation is a crucial event in the pathogenesis of Alzheimer’s disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the β-sheet conformation of Aβ via donor-acceptor-donor hydrogen bond formation. A series of pyridine derivatives, e.g., I•3HCl, were synthesized and tested regarding their potential to inhibit the aggregation of Aβ. The 2,6-diaminopyridine moiety was identified as a key component to inhibit Aβ aggregation. Overall, compounds having three 2,6-disubstituted pyridine units separated by at least one C2- or C3-linker displayed the most potent inhibition of Aβ aggregation. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem