Category: 207801-52-3

Synthesis of functionalized 3-pyridyl methyl ketones was written by Wright, S. W.;Hageman, D. L.;McClure, L. D.. And the article was included in Journal of Heterocyclic Chemistry in 1998.Safety of N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide The following contents are mentioned in the article:

A synthesis of 3-pyridyl Me ketones is described that employs a Pd-catalyzed olefination of 3-bromopyridines with Bu vinyl ether followed by acid hydrolysis of the intermediate pyridyl vinyl ether in situ. This method was applied to bromoquinoline substrates as well. The reaction is compatible with a variety of functional groups. This study involved multiple reactions and reactants, such as N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3Safety of N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide).

N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The synthetic strategy of new pyridine clubbed acetamides via N-alkylation/C-N coupling reaction, sulfonamide drug and their biological approach was written by Yogi, Prabhunath;Prajapat, Prakash;Hussain, Nassir;Dhawan, Heena;Joshi, Ajit. And the article was included in Heterocyclic Letters in 2017.COA of Formula: C12H11BrN2O2S The following contents are mentioned in the article:

A library of novel pyridine motifs assembled with isatin/thiazolidione/sulfonamide/pyrazolone were designed and synthesized via N-alkylation (C-N coupling) approach. The target compounds were obtained by a two step synthetic strategy starting from substituted 2-aminopyridine using appropriate synthetic routes. The synthesized compounds were tested for their in vitro antimicrobial and in vivo anti-inflammatory activity. Some of the compounds were found to be more active than the reference drugs. This study involved multiple reactions and reactants, such as N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3COA of Formula: C12H11BrN2O2S).

N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the èŸ?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the èŸ?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C12H11BrN2O2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M₄ positive allosteric modulator (PAM) chemotype was written by Temple, Kayla J.;Engers, Julie L.;Long, Madeline F.;Watson, Katherine J.;Chang, Sichen;Luscombe, Vincent B.;Jenkins, Matthew T.;Rodriguez, Alice L.;Niswender, Colleen M.;Bridges, Thomas M.;Jeffrey Conn, P.;Engers, Darren W.;Lindsley, Craig W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Name: N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide The following contents are mentioned in the article:

This Letter details the authors’ efforts to discover structurally unique M₄ PAMs containing 5,6-heteroaryl ring systems. In an attempt to improve the DMPK profiles of the 2,3-dimethyl-2H-indazole-5-carboxamide and 1-methyl-1H-benzo[d][1,2,3]triazole-6-carboxamide cores, the authors studied a plethora of core replacements. This exercise identified a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide core that provided improved M₄ PAM activity and CNS penetration. This study involved multiple reactions and reactants, such as N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3Name: N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide).

N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the èŸ?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the èŸ?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper iodide nanoparticles-decorated porous polysulfonamide gel: As effective catalyst for decarboxylative synthesis of N-Arylsulfonamides was written by Alavinia, Sedigheh;Ghorbani-Vaghei, Ramin;Rakhtshah, Jamshid;Yousefi Seyf, Jaber;Ali Arabian, Iman. And the article was included in Applied Organometallic Chemistry in 2020.Formula: C12H11BrN2O2S The following contents are mentioned in the article:

A porous cross-linked poly(ethyleneamine)-polysulfonamide (PEA-PSA) as a novel organic support system was synthesized in the presence of silica template by nanocasting technique. The paper demonstrated immobilization of CuI nanoparticles inside the pores (PEA-PSA@CuI) for the facile recovery and recycling of these nanoparticles. The presence of porous PEA-PSA and PEA-PSA@CuI nanocomposites was confirmed using FT-IR spectroscopy, FE-SEM, EDX, TGA, XRD, TEM, BET, XPS, WDX, ¹H NMR, and ICP-OES techniques. The PEA-PSA@CuI along with Ag(I)/K₂S₂O₈ was implemented as a reusable cooperative catalyst-oxidant system in the decarboxylative cross-coupling of p-toluenesulfonamide with sustituted carboxylic acids in mild condition. Aromatic, secondary and tertiary aliphatic acids underwent high efficient decarboxylative processes with p-toluenesulfonamide to afford the corresponding products. This method provides a practical approach for the flexible synthesis of sulfonamides from the readily affordable substrates. The catalyst was highly reusable and efficient, especially in terms of time and yield of the desired product. This study involved multiple reactions and reactants, such as N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3Formula: C12H11BrN2O2S).

N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C12H11BrN2O2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem