Category: 21190-89-6

Maiden, Tracy M. M. published the artcileSynthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction, Recommanded Product: Ethyl 6-chloropicolinate, the main research area is oxazolylpyridine functionalized preparation rhodium silver catalyzed amidation; azaquinazoline scaffold preparation; pyridopyrimidinone preparation; nicotinamide derivative preparation heterocyclization; picolinamide derivative preparation heterocyclization.

The 1st Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.

Organic Letters published new progress about Amidation. 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Recommanded Product: Ethyl 6-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maiden, Tracy M. M. published the artcileSynthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction, Recommanded Product: Ethyl 6-chloropicolinate, the main research area is oxazolylpyridine functionalized preparation rhodium silver catalyzed amidation; azaquinazoline scaffold preparation; pyridopyrimidinone preparation; nicotinamide derivative preparation heterocyclization; picolinamide derivative preparation heterocyclization.

The 1st Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.

Organic Letters published new progress about Amidation. 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Recommanded Product: Ethyl 6-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tu, Xijuan published the artcileMiniaturized salting-out assisted liquid-liquid extraction combined with disposable pipette extraction for fast sample preparation of neonicotinoid pesticides in bee pollen, SDS of cas: 21190-89-6, the main research area is neonicotinoid pesticide bee pollen pipet salting out liquid extraction; HPLC; bee pollen; disposable pipette extraction; neonicotinoid pesticides; salting-out assisted liquid-liquid extraction; sample preparation.

As the main source of nutrients for the important pollinator honeybee, bee pollen is crucial for the health of the honeybee and the agro-ecosystem. In the present study, a new sample preparation procedure has been developed for the determination of neonicotinoid pesticides in bee pollen. The neonicotinoid pesticides were extracted using miniaturized salting-out assisted liquid-liquid extraction (mini-SALLE), followed by disposable pipet extraction (DPX) for the clean-up of analytes. Effects of DPX parameters on the clean-up performance were systematically investigated, including sorbent types (PSA, C18, and silica gel), mass of sorbent, loading modes, and elution conditions. In addition, the clean-up effect of classical dispersive solid-phase extraction (d-SPE) was compared with that of the DPX method. Results indicated that PSA-based DPX showed excellent clean-up ability for the high performance liquid chromatog. (HPLC) anal. of neonicotinoid pesticides in bee pollen. The proposed DPX method was fully validated and demonstrated to provide the advantage of simple and rapid clean-up with low consumption of solvent. This is the first report of DPX method applied in bee pollen matrix, and would be valuable for the development of a fast sample preparation method for this challenging and important matrix.

Molecules published new progress about Apis mellifera. 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, SDS of cas: 21190-89-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Perry, Matthew W. D. published the artcileDiscovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma, Related Products of pyridine-derivatives, the main research area is AZD8154 PI3K gamma delta inhibitor asthma inhaled.

Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two positions of the mols., including macrocyclization, but ultimately identified a simpler series with the desired potency profile that had suitable physicochem. properties for inhalation. We were able to demonstrate efficacy in a rat ovalbumin challenge model of allergic asthma and in cells derived from asthmatic patients. The optimized compound, AZD8154, has a long duration of action in the lung and low systemic exposure coupled with high selectivity against off-targets.

Journal of Medicinal Chemistry published new progress about Allergic asthma. 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Related Products of pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kametani, Tetsuji published the artcileSyntheses of heterocyclic compounds. CCCLXXI. Synthetic approach to camptothecin, SDS of cas: 21190-89-6, the main research area is camptothecin analog; indolizinoquinoline; quinoline indolizino; pyrrolidinopyridone; pyridone pyrrolidino.

Picolinic acid 1-oxide was esterified with SOCl2 and EtOH to the Et ester, whose treatment with phosphoryl chloride gave Et 6-chloropicolinate (I). Hydrolysis of I with HCl gave 6-oxo-1,6-dihydropicolinic acid (II). Simultaneous condensation and cyclization of the Me ester of II with Me acrylate in the presence of sodium carbonate in DMF yielded the Me, 1,2,3,5-tetrahydro-1,5-dioxoindolizine-2-carboxylate (III). Hydrolysis and decarboxylation of III with HCl gave 3-oxo-pyrrolidino[2,1-f]-2-pyridone (IV). Friedlaender condensation of IV with 2-aminobenzaldehyde gave a camptothecin analog, 9,11-dihydro-9-oxoindolizino[1,2-b]quinoline (V).

Tetrahedron published new progress about camptothecin analog; indolizinoquinoline; quinoline indolizino; pyrrolidinopyridone; pyridone pyrrolidino. 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, SDS of cas: 21190-89-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Riflade, Benoit published the artcilePd-Containing Organopolyoxometalates Derived from Dawson Polyoxometalate [P2W15V3O62]9-: Lewis Acidity and Dual Site Catalysis, Recommanded Product: Ethyl 6-chloropicolinate, the main research area is palladium containing organopolyoxometalate derived Dawson polyoxometalate; Lewis acidity dual site catalysis; allylation sulfonylimine aldehyde.

Grafting of a palladium complex to the Dawson vanadotungstate polyanion [P2W15V3O62]9- via an organic ligand generates a large family of pincer-type hybrid polyoxometalates. The palladium-POM derivatives have dual catalytic properties. Unlike their parent inorganic polyanions, they catalyze allylations while retaining their oxidant character, which leads to single-pot dual site catalysis. This opens a new route for multicatalytic reactions.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Recommanded Product: Ethyl 6-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Chu-Ting published the artcilePd-Catalyzed Vinylation of Aryl Halides with Inexpensive Organosilicon Reagents Under Mild Conditions, Application In Synthesis of 21190-89-6, the main research area is aryl chloride bromide organosilicon reagent vinylation palladium catalyst; Am/Cm separation; cross-coupling; palladium; silicon; substituent effects.

Pd-catalyzed Hiyama vinylation reaction of non-activated aryl chlorides and bromides under mild conditions was developed. The use of efficient vinyl donors and electron-rich sterically hindered phosphine ligands was critical for the success of the reaction. The products of this transformation can be used for Am/Cm separation, an important challenge in nuclear fuel reprocessing. The substituent effect on Am/Cm separating selectivity was also achieved, which could contribute to the development of new chromatog. materials for the separation of Am and Cm.

Chemistry – A European Journal published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Application In Synthesis of 21190-89-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Hong-Jun published the artcileEfficient N-Arylation/Dealkylation of Electron Deficient Heteroaryl Chlorides and Bicyclic Tertiary Amines under Microwave Irradiation, Name: Ethyl 6-chloropicolinate, the main research area is heteroaryl chloroethyl piperazine microwave assisted preparation; arylation dealkylation electron deficient heteroaryl chloride bicyclic tertiary amine; microwave assisted heteroaryl chloroethyl piperidine preparation.

A highly efficient procedure was developed for the microwave-assisted synthesis of N-heteroaryl-4-(2-chloroethyl)piperazines and N-heteroaryl-4-(2-chloroethyl)piperidines. Microwave irradiation of electron deficient heteroaryl chlorides with 1,4-diazabicyclo[2.2.2]octane (DABCO) at 160 °C for 15 min led to N-heteroaryl-4-(2-chloroethyl)piperazines in good to excellent yields. In a similar manner, microwave irradiation of electron deficient heteroaryl chlorides with quinuclidine at 180 °C for 15 min provided N-heteroaryl-4-(2-chloroethyl)piperidines in good to excellent yields. Extension of the method was demonstrated by the development of a one-pot, two-step microwave-assisted protocol for the synthesis of 4-(2-acetoxyethyl)-substituted N-heteroarylpiperazines and N-heteroarylpiperidines to demonstrate the production of a small library in a parallel fashion.

Journal of Combinatorial Chemistry published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent) (hetero). 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Name: Ethyl 6-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Trawny, Daniel published the artcileModular syntheses of star-shaped pyridine, bipyridine, and terpyridine derivatives by employing Sonogashira reactions, Application of Ethyl 6-chloropicolinate, the main research area is pyridine preparation; trialkyne pyridine Sonogashira reaction; bipyridine preparation; bromo bipyridine trialkyne Sonogashira reaction; terpyridine preparation; nonaflate terpyridine trialkyne Sonogashira reaction.

A simple and flexible synthesis for a series C3-sym. core units of star-shaped pyridine e.g., I, bipyridine e.g., II and terpyridine derivatives e.g., III by employing a Sonogashira reaction in the crucial final step was described. A star-shaped dodecafluorinated compound I was also prepared in a straightforward fashion. A simple procedure for the preparation of partially silylated 1,3,5-triethynylbenzene derivatives was presented, which provides an approach to C2-sym. star-shaped compounds that have only one terpyridine and two terphenyl units as ‘dummy’ ligands. The absorption and emission spectra of the fully conjugated C3-sym. pyridine derivatives were systematically investigated, and fairly large Stokes shifts were observed

European Journal of Organic Chemistry published new progress about Pyridines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Application of Ethyl 6-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem