Category: 2127-03-09 00:00:00

Parida, Amarchand; Choudhuri, Khokan; Mal, Prasenjit published the artcile< Unsymmetrical Disulfides Synthesis via Sulfenium Ion>, Formula: C10H8N2S2, the main research area is thiol iodine catalyst umpolung coupling reaction; disulfide preparation; diaryldisulfanes; sulfenium ion; synthetic methods; unsymmetrical disulfides; weak interactions.

An umpolung approach for the synthesis of unsym. disulfides via sulfenium ion was reported. In-situ generated electrophilic sulfenium ion from electron-rich thiols reacted with second thiols to yield unsym. disulfides. Using an iodine catalyst and 4-dimethylaminopyridine (DMAP)/water as promoter, the target synthesis were achieved in one-pot under aerobic condition.

Chemistry – An Asian Journal published new progress about Coupling reaction. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chakraborty, Saptarshi; Khamrui, Rajesh; Ghosh, Suhrit published the artcile< Redox responsive activity regulation in exceptionally stable supramolecular assembly and co-assembly of a protein>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is protein supramol assembly redox responsive activity.

Supramol. assembly of biomols./macromols. stems from the desire to mimic complex biol. structures and functions of living organisms. While DNA nanotechnol. is already in an advanced stage, protein assembly is still in its infancy as it is a significantly difficult task due to their large mol. weight, conformational complexity and structural instability towards variation in temperature, pH or ionic strength. This article reports highly stable redox-responsive supramol. assembly of a protein Bovine serum albumin (BSA) which is functionalized with a supramol. structure directing unit (SSDU). The SSDU consists of a benzamide functionalized naphthalene-diimide (NDI) chromophore which is attached with the protein by a bio-reducible disulfide linker. The SSDU attached protein (NDI-BSA) exhibits spontaneous supramol. assembly in water by off-set π-stacking among the NDI chromophores, leading to the formation of spherical nanoparticles (diameter: 150-200 nm). The same SSDU when connected with a small hydrophilic wedge (NDI-1) instead of the large globular protein, exhibits a different π-stacking mode with relatively less longitudinal displacement which results in a fibrillar network and hydrogelation. Supramol. co-assembly of NDI-BSA and NDI-1 (3 : 7) produces similar π-stacking and an entangled 1D morphol. Both the spherical assembly of NDI-BSA or the fibrillar co-assembly of NDI-BSA + NDI-1 (3 : 7) provide sufficient thermal stability to the protein as its thermal denaturation could be completely surpassed while the secondary structure remained intact. However, the esterase like activity of the protein reduced significantly as a result of such supramol. assembly indicating limited access by the substrate to the active site of the enzyme located in the confined environment. In the presence of glutathione (GSH), a biol. important tri-peptide, due to the cleavage of the disulfide bond, the protein became free and was released, resulting in fully regaining its enzymic activity. Such supramol. assembly provided excellent protection to the protein against enzymic hydrolysis as the relative hydrolysis was estimated to be <30% for the co-assembled protein with respect to the free protein under identical conditions. Similar to bioactivity, the enzymic hydrolysis also became prominent after GSH-treatment, confirming that the lack of hydrolysis in the supramolecularly assembled state is indeed related to the confinement of the protein in the nanostructure assembly. Chemical Science published new progress about Absorption. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Song, Lijuan; Li, Wenhao; Duan, Wenxue; An, Jichao; Tang, Shanyu; Li, Longjia; Yang, Guanyu published the artcile< Natural gallic acid catalyzed aerobic oxidative coupling with the assistance of MnCO3 for synthesis of disulfanes in water>, Reference of 2127-03-9, the main research area is disulfane preparation; thiol oxidative coupling gallic acid organocatalyst.

To pursue a sustainable approach for such a synthesis, an aerobic oxidative coupling method for the efficient preparation of organic disulfanes RSSR1 [R = 4-MeC6H4, cyclohexyl, 2-thienyl, etc.; R1 = t-Bu, 4-ClC6H4, 4-H2NC6H4, etc.], using a low-toxic natural gallic acid as an organocatalyst, inexpensive MnCO3 as a cocatalyst, O2 as the terminal oxidant and water as the solvent, was successfully developed. Such metal-organic cooperative catalytic protocol provided an access to various sym. and unsym. disulfanes in up to 99% yield. Gram scale synthesis with practical convenience and low loading of catalysts further illustrated the practicability of our method.

Green Chemistry published new progress about Disulfides Role: SPN (Synthetic Preparation), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Reference of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhao, Xu; Zhao, Kai-Chao; Chen, Li-Jian; Liu, Yu-Shi; Liu, Jia-Lin; Yan, Xiu-Ping published the artcile< pH Reversibly Switchable Nanocapsule for Bacteria-Targeting Near-Infrared Fluorescence Imaging-Guided Precision Photodynamic Sterilization>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is nanocapsule pH near IR fluorescence imaging photosensitizer; charge reversal targeting; near-infrared fluorescence imaging; pH reversible response; precision photodynamic sterilization; smart nanocapsule.

Photodynamic sterilization is the most promising method to combat bacterial infection, especially multidrug-resistant bacterial infection. However, the absorption of conventional photosensitizers is mostly located in the UV-vis region, leading to limited penetration depth and poor therapeutic efficacy for deep-tissue bacterial infection. Besides, most of the photosensitizers are always in the activated state and lack bacteria-targeting ability, which inevitably causes severe nonspecific damage to normal tissues. Here, we show the design of a pH reversibly switchable near-IR photosensitizer-based nanocapsule for precision bacteria-targeting fluorescence imaging-guided photodynamic sterilization. pH reversibly activatable asym. cyanine was synthesized as a bacteria-specific imaging unit and smart photosensitizer to realize precision imaging-guided targeting sterilization without side effects. An allicin mimic was introduced into the smart photosensitizer as the auxiliary bactericidal group to further enhance antibacterial efficiency. Meanwhile, amphipathic functionalized polyethylene glycol was employed to fabricate the nanocapsule by self-assembly to endow the charge-reversed intelligent targeting ability and prolong blood circulation. The developed switchable nanocapsule not only enables precision bacterial infection-targeted imaging without background fluorescence interference but also gives an efficient bactericidal effect with excellent specificity and negligible side effects, holding great potential for practical application.

ACS Applied Materials & Interfaces published new progress about Near-IR fluorescence. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Shi-yin; Chen, Guo; Chen, Ji-feng; Wang, Jin; Deng, Shao-hui; Cheng, Du published the artcile< Glutathione-depleting polymer delivering chlorin e6 for enhancing photodynamic therapy>, HPLC of Formula: 2127-03-9, the main research area is glutathione depleting polymer deliver photosensitizer chlorin photodynamic therapy.

The therapeutic effect of photodynamic therapy (PDT) is highly dependent on the intracellular production of reactive oxygen species (ROS). However, the ROS generated by photosensitizers can be consumed by the highly concentrated glutathione (GSH) in tumor cells, severely impairing the therapeutic effect of PDT. Herein, we synthesized a GSH-scavenging copolymer to deliver photosensitizer chlorin e6 (Ce6). The pyridyl disulfide groups, which have faster reactivity with the thiol groups of GSH than other disulfide groups, were grafted onto a hydrophobic block to encapsulate the Ce6. Under NIR irradiation, the Ce6 generated ROS to kill tumor cells, and the pyridyl disulfide groups depleted the GSH to prevent ROS consumption, which synergistically enhanced the therapeutic effect of PDT. In vitro and in vivo experiments confirmed the combinatory antitumor effect of Ce6-induced ROS generation and the pyridyl disulfide group-induced GSH depletion. Therefore, the pyridyl disulfide group-grafted amphiphilic copolymer provides a more efficient strategy for enhancing PDT and has promising potential for clin. application.

RSC Advances published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, HPLC of Formula: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhan, Yu-Rong; Yu, Qing-Ying; Zhang, Ji; Liu, Yan-Hong; Xiao, Ya-Ping; Zhang, Ju-Hui; He, Xi; Yu, Xiao-Qi published the artcile< Glutathione modified low molecular weight PEI for highly improved gene transfection ability and biocompatibility>, Category: pyridine-derivatives, the main research area is glutathione PEI gene transfection biocompatibility.

The efficient delivery of therapeutic genes remains a major challenge in realizing a feasible gene-based treatment. Herein, a versatile oligopeptide, glutathione, was introduced to construct novel non-viral cationic gene vectors. Reduced/oxidized forms of glutathione (GSH/GSSG) and relevant amino acids (Glu, Cys, and Gly) were used to modify low mol. weight PEI through surface modification or crosslinking. These polymers could bind well and condense DNA into spherical nanoparticles, which were stable in the presence of serum. The disulfide bonds within the crosslinked polymer GSSG-PEI may facilitate polymer degradation and DNA release under a reductive environment. In vitro transfection experiments reveal that the modification could largely improve the gene transfection efficiency of low mol. weight PEI, especially in the presence of serum. In HeLa cells, GSSG-PEI could even give up to 150 times higher efficiency than PEI 25 kDa. TEM and serum concentration effect assay also demonstrate the good serum tolerance of the polymers. Flow cytometry results show that GSSG-PEI might induce cellular uptake with higher efficiency than PEI 25 kDa, especially in the presence of serum. Results reveal that GSSG is a good candidate for the crosslinking of small cationic mols. to form polymeric gene vectors with improved transfection efficiency and biocompatibility.

New Journal of Chemistry published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pandopulos, Aaron J.; Gerber, Cobus; Tscharke, Benjamin J.; O’Brien, Jake; White, Jason M.; Bade, Richard published the artcile< A sensitive analytical method for the measurement of neurotransmitter metabolites as potential population biomarkers in wastewater>, Application of C10H8N2S2, the main research area is neurotransmitter metabolite determination wastewater analysis; liquid chromatog tandem mass spectrometry neurotransmitter metabolite determination wastewater; population biomarker wastewater epidemiol neurotransmitter metabolite determination; hydroxyindoleacetic acid vanillylmandelic acid homovanillic acid neurotransmitter metabolite biomarker; 5-hydroxyindoleacetic acid; Homovanillic acid; Mass spectrometry; Population biomarker; Vanillylmandelic acid; Wastewater-based epidemiology.

Wastewater-based epidemiol. is a growing research field which provides valuable information on community drug use and chem. exposure. One parameter critical to estimate drug use is catchment area population. A population biomarker could provide this information. This work evaluated the anal. suitability of three human activity endogenous biomarkers: the previously proposed serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA); and two other candidates, the catecholamine metabolites, vanillylmandelic acid (VMA) and homovanillic acid (HVA). A derivatization-involved anal. method was developed and validated for 5-HIAA and HVA: liquid chromatog./mass spectrometry. Best performance was obtained for VMA as an underivatized analyte. Derivatized extracts produced 100 times better sensitivity. The three neurotransmitter metabolites were evaluated as population biomarkers in wastewater. All were stable, not lost upon filtration, and displayed stable inter-day mass loads over seven days for a metropolitan wastewater treatment facility. When used for a small community during a festival, mass HVA and VMA loads reflected an increase in catchment population; 5-HIAA was more variable.

Journal of Chromatography A published new progress about Biomarkers (endogenous human activity neurotransmitter metabolite). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de la Fuente-Herreruela, Diego; Monnappa, Ajay K.; Munoz-Ubeda, Monica; Morallon-Pina, Aaron; Enciso, Eduardo; Sanchez, Luis; Giusti, Fabrice; Natale, Paolo; Lopez-Montero, Ivan published the artcile< Lipid-peptide bioconjugation through pyridyl disulfide reaction chemistry and its application in cell targeting and drug delivery>, Product Details of C10H8N2S2, the main research area is lipid peptide bioconjugation pyridyl disulfide liposome delivery cell target; Disulfide bonds; Endosomal escape; GALA; Smart liposomes; Targeting peptide.

The design of efficient drug delivery vectors requires versatile formulations able to simultaneously direct a multitude of mol. targets and to bypass the endosomal recycling pathway of cells. Liposomal-based vectors need the decoration of the lipid surface with specific peptides to fulfill the functional requirements. The unspecific binding of peptides to the lipid surface is often accompanied with uncontrolled formulations and thus preventing the mol. mechanisms of a successful therapy. We present a simple synthesis pathway to anchor cysteine-terminal peptides to thiol-reactive lipids for adequate and quant. liposomal formulations. As a proof of concept, we have synthesized two different lipopeptides based on (a) the truncated Fibroblast Growth Factor (tbFGF) for cell targeting and (b) the pH sensitive and fusogenic GALA peptide for endosomal scape. The incorporation of these two lipopeptides in the liposomal formulation improves the fibroblast cell targeting and promotes the direct delivery of cargo mols. to the cytoplasm of the cell.

Journal of Nanobiotechnology published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rangasami, Vignesh K.; Nawale, Ganesh; Asawa, Kenta; Kadekar, Sandeep; Samanta, Sumanta; Nilsson, Bo; Ekdahl, Kristina N.; Miettinen, Susanna; Hilborn, Jons; Teramura, Yuji; Varghese, Oommen P.; Oommen, Oommen P. published the artcile< Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells>, Application In Synthesis of 2127-03-9, the main research area is Pluronic micelle tissue factor silencing hemocompatibility mesenchyme stem cell.

Mesenchymal stem/stromal cells (MSCs) evoke great excitement for treating different human diseases due to their ability to home inflamed tissues, suppress inflammation, and promote tissue regeneration. Despite great promises, clin. trial results are disappointing as allotransplantation of MSCs trigger thrombotic activity and are damaged by the complement system, compromising their survival and function. To overcome this, a new strategy is presented by the silencing of tissue factor (TF), a transmembrane protein that mediates procoagulant activity. Novel Pluronic-based micelles are designed with the pendant pyridyl disulfide group, which are used to conjugate TF-targeting siRNA by the thiol-exchange reaction. This nanocarrier design effectively delivered the payload to MSCs resulting in ~72% TF knockdown (KD) without significant cytotoxicity. Hematol. evaluation of MSCs and TF-KD MSCs in an ex vivo human whole blood model revealed a significant reduction in an instant-blood-mediated-inflammatory reaction as evidenced by reduced platelet aggregation (93% of free platelets in the TF-KD group, compared to 22% in untreated bone marrow-derived MSCs) and thrombin-antithrombin complex formation. Effective TF silencing induced higher MSC differentiation in osteogenic and adipogenic media and showed stronger paracrine suppression of proinflammatory cytokines in macrophages and higher stimulation in the presence of endotoxins. Thus, TF silencing can produce functional cells with higher fidelity, efficacy, and functions.

Biomacromolecules published new progress about Cell differentiation. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Song, Min-Young; Hwang, Ji Yeon; Bae, Eun Ji; Kim, Saesbyeol; Kang, Hye-Min; Kim, Yong Jun; Park, Chan; Park, Kang-Sik published the artcile< Tyrosine phosphorylation of the Kv2.1 channel contributes to injury in brain ischemia>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is tyrosine phosphorylation potassium channel brain ischemia injury; Kv2.1; brain ischemia; oxidative stress; tyrosine phosphorylation.

In brain ischemia, oxidative stress induces neuronal apoptosis, which is mediated by increased activity of the voltage-gated K+ channel Kv2.1 and results in an efflux of intracellular K+. The mol. mechanisms underlying the regulation of Kv2.1 and its activity during brain ischemia are not yet fully understood. Here this study provides evidence that oxidant-induced apoptosis resulting from brain ischemia promotes rapid tyrosine phosphorylation of Kv2.1. When the tyrosine phosphorylation sites Y124, Y686, and Y810 on the Kv2.1 channel are mutated to non-phosphorylatable residues, PARP-1 cleavage levels decrease, indicating suppression of neuronal cell death. The tyrosine residue Y810 on Kv2.1 was a major phosphorylation site. In fact, cells mutated Y810 were more viable in our study than were wild-type cells, suggesting an important role for this site during ischemic neuronal injury. In an animal model, tyrosine phosphorylation of Kv2.1 increased after ischemic brain injury, with an observable sustained increase for at least 2 h after reperfusion. These results demonstrate that tyrosine phosphorylation of the Kv2.1 channel in the brain may play a critical role in regulating neuronal ischemia and is therefore a potential therapeutic target in patients with brain ischemia.

International Journal of Molecular Sciences published new progress about Apoptosis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem