Category: 2127-03-09 00:00:00

Ishigeev, Roman S.; Potapov, Vladimir A.; Shkurchenko, Irina V.; Zinchenko, Sergey V.; Amosova, Svetlana V. published the artcile< Two types of products in the reactions of 2-pyridinesulfenyl halides with cycloalkenes and cycloalkadienes: synthesis of novel [1,3]thiazolo[3,2-a]pyridinium derivatives>, Computed Properties of 2127-03-9, the main research area is thiazolopyridinium compound preparation; pyridinesulfenyl halide cycloalkene cyclocondensation; cycloalkenyl sulfanylpyridine preparation; cycloalkene pyridinesulfenyl halide electrophilic addition.

The reactions of 2-pyridinesulfenyl halides like 2-pyridinesulfenyl chloride and 2-pyridylsulfenyl bromide with cyclopentene, 1,4-cyclohexadiene, 1,5-cyclooctadiene, 1,3-cyclooctadiene, and norbornene, depending on the structure of the alkene, the nature of the halogen, and the duration of the process, lead to the formation of two types of adducts, electrophilic addition products, e.g., I or condensed compounds, [1,3]thiazolo[3,2-a]pyridinium derivatives, e.g., II in high yields.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Cycloalkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Computed Properties of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Peiru; Wang, Dali; Wang, Yuyan; Zhang, Lei; Wang, Qiwei; Liu, Lanxia; Li, Jiahe; Sun, Xin; Ren, Mengqi; Wang, Ruoxuan; Fang, Yang; Zhao, Jean J.; Zhang, Ke published the artcile< Maximizing TLR9 Activation in Caner Immunotherapy with Dual-Adjuvanted Spherical Nucleic Acids>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is cancer immunotherapy dual adjuvanted spherical nucleic acid TLR9; CpG oligonucleotides; DNA amphiphiles; cancer vaccines; spherical nucleic acids.

Nucleic-acid-based immune adjuvants have been extensively investigated for the design of cancer vaccines. However, nucleic acids often require the assistance of a carrier system to improve cellular uptake. Yet, such systems are prone to carrier-associated adaptive immunity, leading to difficulties in a multidose treatment regimen. Here, we demonstrate that a spherical nucleic acid (SNA)-based self-adjuvanting system consisting of phosphodiester oligonucleotides and vitamin E can function as a potent anticancer vaccine without a carrier. The two functional modules work synergistically, serving as each other′s delivery vector to enhance toll-like receptor 9 activation. The vaccine rapidly enters cells carrying OVA model antigens, which enables efficient activation of adaptive immunity in vitro and in vivo. In OVA-expressing tumor allograft models, both prophylactic and therapeutic vaccinations significantly retard tumor growth and prolong animal survival. Furthermore, the vaccinations were also able to reduce lung metastasis in a B16F10-OVA model.

Nano Letters published new progress about Adaptive immunity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guzyr, Olexandr I.; Kozel, Volodymyr N.; Rusanov, Eduard B.; Rozhenko, Olexandr B.; Fetyukhin, Volodymyr N.; Shermolovich, Yuriy G. published the artcile< Enhanced preparation of aryl and heteryl sulfur pentafluorides using mercury (II) oxide - hydrogen fluoride media as a fluorinating reagent>, Product Details of C10H8N2S2, the main research area is aryl sulfur pentafluoride preparation DFT.

An enhanced method for the synthesis of aryl sulfur pentafluorides ArSF5 [Ar = Ph, 2-pyridyl, 3H-1,3-benzothiazol-2-yl, etc.] from chlorotetrafluorides using mercury oxide-hydrogen fluoride and mercury oxide-pyridinium poly(hydrogen fluoride) media as the fluorinating reagents was developed at low temperature and in good yield. X-Ray crystallog. anal. of compounds ArSF5 [Ar = 3H-1,3-benzothiazol-2-yl, pyrimidin-2-yl] showed distorted octahedral environment of sulfur atom and elongated C-S bond length for pyrimidinium compound

Journal of Fluorine Chemistry published new progress about Aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xuefu; Wang, Jun; Yu, Miao; Zhang, Xiaona; Wang, Wei; Tian, Hua; Ru, Shaoguo published the artcile< 2,2'-Dithiobis-pyridine induced reproductive toxicity in male guppy (Poecilia reticulata)>, Product Details of C10H8N2S2, the main research area is dithiobis pyridine Poecilia reticulata reproductive toxicity sperm motility; 2,2′-Dithiobis-pyridin; Poecilia reticulata; Reproductive toxicity; Sex steroid hormone; Sperm motility.

Metal pyrithiones (MePTs) are frequently used antifouling biocides in marine coatings. Their main degradation product, 2,2′-dithiobis-pyridine ((PS)2), has been widely detected in seawater and may pose potential ecol. risks. In the present study, sexually mature guppies (Poecilia reticulata) were exposed to (PS)2 at concentrations of 0, 20, 200, and 2000 ng/L for 28 days to investigate its reproductive toxicity. The results showed that (PS)2 significantly reduced testosterone (T) levels, spermatogenic cyst number and sperm motility, impeded spermatogenic cell differentiation in male guppies and delayed embryo development in females. These results indicated that (PS)2 could cause reproductive toxicity in guppies. We also examined mRNA expression of indexes involved in the hypothalamic-pituitary-gonadal axis and reproductive behaviors. We found that 200 and 2000 ng/L (PS)2 decreased T synthesis by downregulating 17βHSD and CYP17 mRNA levels, and upregulating the mRNA level of CYP19a1a, which converted T to 17β-estradiol. (PS)2 also upregulated GnRH1, FSHβ, LHβ, and LHR mRNA levels, a pos. feedback regulation due to the decrease of T levels in male guppies. Furthermore, (PS)2 significantly decreased CYP19a1b mRNA levels in all three exposure groups and thus reduced the display frequency of male guppies. This study was the first to report that (PS)2 could induce reproductive toxicity, which would provide a basis for future assessment of its ecol. risk.

Ecotoxicology and Environmental Safety published new progress about Acute toxicity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Birchall, Lee T.; Truccolo, Giada; Jackson, Lewis; Shepherd, Helena J. published the artcile< Co-crystallisation as a modular approach to the discovery of spin-crossover materials>, Synthetic Route of 2127-03-9, the main research area is bispyrazolyl pyridine cocrystn spin crossover material.

Herein we present co-crystallization as a strategy for materials discovery in the field of switchable spin crossover (SCO) systems. Using [Fe(3-bpp)2]·2A (where 3-bpp = 2,6-bis(pyrazol-3-yl)pyridine, A = BF4-/PF6-) as a starting point, a total of 11 new cocrystals have been synthesized with five different dipyridyl coformers. Eight of these systems show spin crossover behavior, and all show dramatically different switching properties from the parent complex. The cocrystals have been studied by variable temperature single-crystal X-ray diffraction and SQUID magnetometry to develop structure-property relationships. The supramol. architecture of the cocrystals depends on the properties of the coformer. With linear, rigid coformer mols. leading to 1D supramol. hydrogen-bonded chains, while flexible coformers form 2D sheets and bent coformers yield 3D network structures. The SCO behavior of the cocrystals can be modified through changing the coformer and thus co-crystallization presents a rapid, facile and highly modular tool for the discovery of new switchable materials. The wider applicability of this strategy to the design of hybrid multifunctional materials is also discussed.

Chemical Science published new progress about Cooling. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiang, Ziwen; Cui, Wei; Prasad, Priyaa; Touve, Mollie A.; Gianneschi, Nathan C.; Mager, Jesse; Thayumanavan, S. published the artcile< Bait-and-Switch Supramolecular Strategy To Generate Noncationic RNA-Polymer Complexes for RNA Delivery>, Quality Control of 2127-03-9, the main research area is RNA vector polymer.

RNA interference (RNAi) requires the intracellular delivery of RNA mols. to initiate the neutralization of targeted mRNA mols., inhibiting the expression or translation of the targeted gene. Current polymers and lipids that are used to deliver RNA mols. are generally required to be pos. charged, to achieve complexation with RNA and the cellular internalization. However, pos. surface charge has been implicated as the reason for toxicity in many of these systems. Herein, we report a novel strategy to generate noncationic RNA-polymer complexes for RNA delivery with low cytotoxicity. We use an in situ electrostatic complexation using a methylated pyridinium group, which is simultaneously removed during the RNA binding step. The resultant complexes demonstrate successful knockdown in preimplantation mammalian embryos, thus providing a new approach for nucleic acid delivery.

Biomacromolecules published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Quality Control of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Kaibo; Varatnitskaya, Marharyta; Maghnouj, Abdelouahid; Bader, Verian; Winklhofer, Konstanze F.; Hahn, Stephan; Leichert, Lars I. published the artcile< Activation leads to a significant shift in the intracellular redox homeostasis of neutrophil-like cells>, SDS of cas: 2127-03-9, the main research area is neutrophil NOX2 redox homeostasis Escherichia.

Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils′ redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling, e.g. during the initiation of the production of neutrophil extracellular traps (NETs). Using the genetically encoded redox sensor roGFP2, expressed in the cytoplasm of the neutrophil-like cell line PLB-985, we saw that stimulation by both PMA and E. coli resulted in oxidation of the thiol residues in this probe. In contrast to the redox state of phagocytized bacteria, which completely breaks down, the neutrophils′ cytoplasmic redox state switched from its intital -318 ± 6 mV to a new, albeit higher oxidized, steady state of -264 ± 5 mV in the presence of bacteria. This highly significant oxidation of the cytosol (p value = 7 × 10-5) is dependent on NOX2 activity, but independent of the most effective thiol oxidant produced in neutrophils, MPO-derived HOCl. While the shift in the intracellular redox potential is correlated with effective NETosis, it is, by itself not sufficient: Inhibition of MPO, while not affecting the cytosolic oxidation, significantly decreased NETosis. Furthermore, inhibition of PI3K, which abrogates cytosolic oxidation, did not fully prevent NETosis induced by phagocytosis of bacteria. Thus, we conclude that NET-formation is regulated in a multifactorial way, in part by changes of the cytosolic thiol redox homeostasis in neutrophils, depending on the circumstance under which the generation of NETs was initiated.

Redox Biology published new progress about Cytosol Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem