Category: 2127-03-9

Anson, Francesca; Thayumanavan, S.; Hardy, Jeanne A. published the artcile< Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is initiator executioner caspase apoptosis.

The balance of pro-apoptotic and pro-survival proteins defines a cell′s fate. These processes are controlled through an interdependent and finely tuned protein network that enables survival or leads to apoptotic cell death. The caspase family of proteases is central to this apoptotic network, with initiator and executioner caspases, and their interaction partners, regulating and executing apoptosis. In this work, we interrogate and modulate this network by exogenously introducing specific initiator or executioner caspase proteins. Each caspase is exogenously introduced using redox-responsive polymeric nanogels. Although caspase-3 might be expected to be the most effective due to the centrality of its role in apoptosis and its heightened catalytic efficiency relative to other family members, we observed that caspase-7 and caspase-9 are the most effective at inducing apoptotic cell death. By critically analyzing the introduced activity of the delivered caspase, the pattern of substrate cleavage, as well as the ability to activate endogenous caspases, we conclude that the efficacy of each caspase correlated with the levels of pro-survival factors that both directly and indirectly impact the introduced caspase. These findings lay the groundwork for developing methods for exogenous introduction of caspases as a therapeutic option that can be tuned to the apoptotic balance in a proliferating cell.

JACS Au published new progress about Apoptosis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Minmin; Hu, Jinxia; Wang, Lujing; Li, Yanru; Zhu, Chenghao; Chen, Chen; Shi, Ming; Ju, Zhicheng; Cao, Xichuan; Zhang, Zhuoqi published the artcile< Targeted and redox-responsive drug delivery systems based on carbonic anhydrase IX-decorated mesoporous silica nanoparticles for cancer therapy>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is silica nanoparticle carbonic anhydrase cancer therapy redox drug delivery.

In this work, we developed a new antibody-targeted and redox-responsive drug delivery system “”MSNs-CAIX”” by binding the anti-carbonic anhydrase IX antibody (A-CAIX Ab) on the surface of mesoporous silica nanoparticles (MSNs) via disulfide linkages. The design of the composite particles “”MSNs-CAIX”” involved the synthesis and surface functionalization with thiol groups, 2,2′-dipyridyl disulfide and CAIX antibody. In vitro, CAIX capping the doxorubicin hydrochloric (DOX)-loaded nanoparticles (DOX@MSNs-CAIX) exhibited effectively redox-responsive release in the presence of glutathione (GSH) owing to the cleavage of the disulfide bond. Compared with CAIX neg. Mef cells (mouse embryo fibroblast), remarkably more DOX@MSNs-CAIX was internalized into CAIX pos. 4T1 cells (mouse breast cancer cells) by receptor-mediation. Tumor targeting in vivo studies clearly demonstrated DOX@MSNs-CAIX accumulated in tumors and induced more tumor cells apoptosis in 4T1 tumor-bearing mice. With great potential, this drug delivery system is a promising candidate for targeted and redox-responsive cancer therapy.

Scientific Reports published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Buyin; Xu, Yang; Wang, Tianqi; Gao, Shengguang; Meng, Guojie; Huang, Kun published the artcile< Ag nanoparticles encapsulated in carboxyl-functionalized hollow microporous organic nanospheres for highly efficient catalysis applications>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is carboxyl functionalized hollow microporous organic nanosphere silver nanoparticle; catalysis application.

In this work, we present a novel synthesis of Ag nanoparticles encapsulated in carboxyl-functionalized hollow microporous organic nanospheres (Ag@COOH-HMONs) by a combination of hyper-crosslinking mediated self-assembly and simply impregnation method, in which the COOH-HMONs supports were prepared via a Friedel-Crafts alkylation reaction by using polylactide-b-poly(tertbutyl acrylate)-b-polystyrene (PLA-b-PtBA-b-PS) triblock copolymer as precursors. Owing to the abundant carboxyl groups in the cavity of COOH-HMONs, highly dispersed silver nanoparticles can be successfully anchored into COOH-HMONs to produce Ag@COOH-HMONs via an ion exchange with AgNO3 following by an in-situ reduction of sodium borohydride (NaBH4). The obtained Ag@COOH-HMONs exhibit the high catalytic activities for the reduction of MB and nitroarom. compounds as well as selective oxidation of thiol and styrene due to their high surface area, hierarchical porosity and yolk-shell nanostructure. This approach of constructing novel metal@porous organic polymers is expected to open doors for new types of yolk-shell structural catalysts for practical applications.

Applied Catalysis, A: General published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Potapov, V. A.; Ishigeev, R. S.; Shkurchenko, I. V.; Amosova, S. V. published the artcile< Assembling of Thiazolo[3,2-a]pyridinium Salts via the Reaction of 2-Pyridinesulfenyl Halides with Vinyl Ethyl Ether>, Category: pyridine-derivatives, the main research area is pyridinesulfenyl halide vinyl ethyl ether regioselective heterocyclization; ethoxy thiazolopyridinum halide preparation.

The regio- and stereoselective synthesis of 3-ethoxy-2H,3H-[1,3]thiazolo[3,2-a]pyridin-4-ium halides via the reaction of 2-pyridinesulfenyl halides with vinyl Et ether was elaborated.

Russian Journal of General Chemistry published new progress about Ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Keping; Ding, Chengqiang; Liu, Xiaolin; Gao, Jun; Wu, Datong; Qin, Yong; Kong, Yong published the artcile< A redox and pH dual-triggered drug delivery platform based on chitosan grafted tubular mesoporous silica>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is chitosan tubular mesoporous silica hydrogen ion concentration drug delivery.

Tubular mesoporous silica (T-mSiO2) was facilely synthesized through a co-template method by using cetyltrimethylammonium bromide and α-Fe2O3 as the dual templates, and then disulfide (-SS-) bonds and carboxyl groups (-COOH) were introduced to the resultant T-mSiO2 via the reaction with 2-carboxyethyl 2-pyridyl disulfide. The obtained -SS- grafted T-mSiO2 (SS-T-mSiO2) was then grafted with chitosan (CS) via the amidation reaction between the -COOH groups on SS-T-mSiO2 and the -NH2 groups on CS. The CS grafted SS-T-mSiO2 (CS-SS-T-mSiO2) was fully characterized by various technologies such as transmission electron microscopy, energy dispersive X-ray spectroscopy and Fourier transform IR spectroscopy. Finally, the as-synthesized CS-SS-T-mSiO2 was used as the carrier for redox and pH dual-triggered delivery of 5-fluorouracil (5-FU), an anti-cancer drug, and the results indicate that the developed CS-SS-T-mSiO2 might be a potential responsive carrier for redox and pH dual-triggered drug delivery.

Ceramics International published new progress about Amidation. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Juan; Yu, Yuhua; Zhao, Jie; Zhao, Peng; Wen, Xuejun; Zhuang, Zhigang; Lin, Chao published the artcile< Integrating disulfides into a polyethylenimine gene carrier selectively boosts significant transfection activity in lung tissue enabling robust IL-12 gene therapy against metastatic lung cancers>, HPLC of Formula: 2127-03-9, the main research area is integrating disulfide polyethylenimine interleukin human metastatic lung cancer; Disulfide; Interleukin-12; Metastatic lung cancer; Polyethylenimine; Transfection.

Bioreducible polyethylenimines (SSPEIs) are promising non-viral carriers for cancer gene therapy. However, the availability of significant gene transfection activity by SSPEIs remains a challenge. Herein, an essential step was taken to ascertain whether or not the disulfide bonds of SSPEIs play a critical role in promoting significant gene transfection activity in different tissues. Initially, a disulfide-linked linear polyethylenimine (denoted as SSLPEI) consisting of one 5.0 kDa LPEI main chain and three disulfide-linked 5.7 kDa LPEI grafts was designed and prepared to possess similar mol. weight with commercialized 25 kDa LPEI as a pos. control. The SSLPEI could induce superior in vitro transfection activity in different cells to the LPEI control as well as low cytotoxicity. Notably, such enhanced in vitro transfection effect by the SSLPEI was more marked in type-II alveolar epithelial cells compared to different cancer cells. In a Balb/c nude mouse model bearing SKOV-3 tumor, the SSLPEI caused parallel level of transgene expression with the LPEI control in the tumor but significantly higher level in the mouse lung. Furthermore, the SSLPEI and LPEI groups afforded an identical antitumor efficacy against the SKOV-3 tumor via i.v. delivery of a shRNA for silencing VEGF expression in the tumor. However, via i.v. delivery of an interleukin-12 (IL-12) gene into metastatic lung cancers in a C57BL/6 mouse model, the SSLPEI group exerted markedly higher IL-12 expression level in the mouse lung and peripheral blood as compared to the LPEI group, thereby boosting IL-12 immunotherapy against the lung metastasis with longer medium survival time. The results of this work elicit that the disulfide bonds of SSPEIs play a pivotal role in enhancing gene transfection activity selectively in the lung tissue rather than solid tumor, enabling high translational potential of SSPEIs for non-viral gene therapy against metastatic lung cancers.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about Alveolar epithelium. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, HPLC of Formula: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Harenberg, Johannes H.; Weidmann, Niels; Knochel, Paul published the artcile< Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow>, SDS of cas: 2127-03-9, the main research area is metalation continuous flow generation organopotassium aromatic hetaryl nucleophile; electrophile addition coupling organopotassium aromatic heterocyclic compound; alc ketone thioether silane preparation organopotassium nucleophile addition coupling; arenes; flow chemistry; heteroarenes; lateral metalation; potassium.

Heterocyclic and aromatic compounds were metalated by lithium-free potassium diisopropylamide serving as nucleophiles in carbonyl group addition and coupling reactions, providing access to versatile substituted benzothiazoles, benzothiophenes, benzofurans and functionalized aromatic compounds We report the preparation of lithium-salt-free KDA (potassium diisopropylamide; 0.6 M in hexane) complexed with TMEDA (N,N,N’,N’-tetramethylethylenediamine) and its use for the flow-metalation of (hetero)arenes between -78° and 25° with reaction times between 0.2 s and 24 s and a combined flow rate of 10 mL min-1 using a com. flow setup. The resulting potassium organometallics react instantaneously with various electrophiles, such as ketones, aldehydes, alkyl and allylic halides, disulfides, Weinreb amides, and Me3SiCl, affording functionalized (hetero)arenes in high yields. This flow procedure is successfully extended to the lateral metalation of methyl-substituted arenes and heteroaromatics, resulting in the formation of various benzylic potassium organometallics. A metalation scale-up was possible without further optimization.

Angewandte Chemie, International Edition published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Yuman; Liu, Peng published the artcile< Reduction-triggered di-block copolymer prodrug for high-performance long-acting tumor-selective killing>, Related Products of 2127-03-9, the main research area is acrylic polyoxyalkylene diblock progrug antitumor agent; Long-acting prodrug; Reduction-triggered drug delivery; Solubility-controlled release; Tumor-selective killing; Tumor-specific.

Long-acting drug delivery systems (DDSs) have attracted interests for tumor chemotherapy. Here, novel reduction-triggered polymer prodrug was designed by conjugation of a high-performance thiolated doxorubicin (DOX-SH) onto the diblock copolymer PEG43-PPDSM43 via the bioreducible cleavable disulfide bond. The resultant polymer prodrug PEG43-PPDSM43-DOX with a DOX content of 33% could be easily self-assembled into nanoparticles of 146 nm. They showed a slow solubility-controlled sustained drug release with a cumulative release of 30.13% within 84 h in the simulated tumor intracellular microenvironment but an ultra-low premature drug leakage of 4.01% in the simulated normal physiol. media. Such slow sustained release is expected to prolong the action time of the active drug. The MTT assays demonstrated the tumor-selective killing performance of the proposed prodrug nanoparticles with an enhanced antitumor efficacy on the tumor HepG2 cells than the free DOX, but no obvious cytotoxicity on the normal L20 cells at the lower dosages.

Colloids and Surfaces, B: Biointerfaces published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kang, Yan-Shang; Zhang, Ping; Li, Min-Yan; Chen, You-Ke; Xu, Hua-Jin; Zhao, Jing; Sun, Wei-Yin; Yu, Jin-Quan; Lu, Yi published the artcile< Ligand-Promoted RhIII-Catalyzed Thiolation of Benzamides with a Broad Disulfide Scope>, Reference of 2127-03-9, the main research area is benzamide pentafluorophenyl disulfide rhodium amino acid regioselective thiolation catalyst; arylthio pentafluorophenyl benzamide preparation; amino acids; directing groups; disulfides; rhodium; thiolation.

A ligand-promoted RhIII-catalyzed C(sp2)-H activation/thiolation of benzamides has been developed. Using bidentate mono-N-protected amino acid ligands led to the first example of RhIII-catalyzed aryl thiolation reactions directed by weakly coordinating directing amide groups. The reaction tolerates a broad range of amides and disulfide reagents.

Angewandte Chemie, International Edition published new progress about Amino acids Role: CAT (Catalyst Use), USES (Uses). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Reference of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Dan-Yang; Si, Yubing; Li, Junjie; Fu, Yongzhu published the artcile< Tuning the electrochemical behavior of organodisulfides in rechargeable lithium batteries using N-containing heterocycles>, Electric Literature of 2127-03-9, the main research area is organodisulfide tuning electrochem behavior rechargeable lithium battery.

S-S bonds in organodisulfides can break and obtain Li+ and e- in the discharge of lithium batteries. Organodisulfides provide precise lithiation sites, and therefore are valuable models for the study of redox reactions in lithium batteries. To understand their electrochem. behavior, we investigate three disulfides with different N-containing heterocycles including 2,2′-dipyridyl disulfide (2,2′-DpyDS), 4,4′-dipyridyl disulfide (4,4′-DpyDS), and 2,2′-dipyridyl disulfide-N,N’-dioxide (DpyDSDO). The three disulfides all show higher discharge voltage plateaus due to the electron-withdrawing groups: DPDS (2.20 V) < 2,2'-DpyDS (2.45 V) = 4,4'-DpyDS (2.45 V) < DpyDSDO (2.80 V). In particular, 2,2'-DpyDS exhibits an outstanding 69% capacity retention over 500 cycles. Our theor. simulations show that lithium pyridine-2-thiolate, the discharge product of 2,2'-DpyDS, forms compact clusters via N···Li···S bridges coordinated by lithium ions, which can help reduce its dissolution in liquid electrolyte, and therefore increase the cycle life. Liquid chromatog.-mass spectrometry is demonstrated to be a powerful tool for the investigation of discharge/recharge products of soluble organodisulfides in rechargeable lithium batteries. Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Battery cathodes. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Electric Literature of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem