Category: 2127-03-9

Fang, Lei; Zhao, Zitong; Wang, Jue; Xiao, Ping; Sun, Xiangshi; Ding, Yaping; Zhang, Pengcheng; Wang, Dangge; Li, Yaping published the artcile< Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer>, SDS of cas: 2127-03-9, the main research area is charge reversal nanoparticle polyinosinic polycytidylic acid delivery cancer immunotherapy; Cancer immunotherapy; Charge-reversal; Nanoparticles; Photodynamic therapy; Polyinosinic-polycytidylic acid; ROS-responsive; Triple negative breast cancer; Tumor microenvironment.

Nucleic acid drugs are highly applicable for cancer immunotherapy with promising therapeutic effects, while targeting delivery of these drugs to disease lesions remains challenging. Cationic polymeric nanoparticles have paved the way for efficient delivery of nucleic acid drugs, and achieved stimuli-responsive disassembly in tumor microenvironment (TME). However, TME is highly heterogeneous between individuals, and most nanocarriers lack active-control over the release of loaded nucleic acid drugs, which will definitely reduce the therapeutic efficacy. Herein, we have developed a light-controllable charge-reversal nanoparticle (LCCN) with controlled release of polyinosinic-polycytidylic acid [Poly(I:C)] to treat triple neg. breast cancer (TNBC) by enhanced photodynamic immunotherapy. The nanoparticles keep suitably pos. charge for stable loading of Poly(I:C), while rapidly reverse to neg. charge after near-IR light irradiation to release Poly(I:C). LCCN-Poly(I:C) nanoparticles trigger effective phototoxicity and immunogenic cell death on 4T1 tumor cells, elevate antitumor immune responses and inhibit the growth of primary and abscopal 4T1 tumors in mice. The approach provides a promising strategy for controlled release of various nucleic acid-based immune modulators, which may enhance the efficacy of photodynamic immunotherapy against TNBC.

Acta Pharmaceutica Sinica B published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Rui-Qian; Liu, Zhan-Qing; Luo, Yan-Ling; Xu, Feng; Chen, Ya-Shao published the artcile< Tri-stimuli responsive carbon nanotubes covered by mesoporous silica graft copolymer multifunctional materials for intracellular drug delivery>, Application In Synthesis of 2127-03-9, the main research area is carbon silica graft copolymer multifunctional material intracellular drug delivery.

To overcome premature drug leakage and instability in drug delivery systems, we designed tri-stimuli responsive multiwalled carbon nanotubes covered by mesoporous silica graft poly(N-isopropylacrylamide-block-poly(2-(4-formylbenzoyloxy)) Et methacrylate) multifunctional materials via disulfide linkages (MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA). The multifunctional materials could covalently bind and phys. load anticancer drug doxorubicin (DOX), and exhibited pH-, temperature- and reductant-induced multi-stimuli responsiveness, significantly enhancing drug loading capacity and improving the release dynamics of drug. The DOX-loaded multifunctional materials exhibited the optimal release behavior in cancer environments compared with in normal cells upon simultaneously triggered by these stimuli. It meant that the MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA could serve as efficient gatekeepers to control the mesopore on-off and thus to modulate drug release. The multifunctional materials were proved to be low toxic, whereas the DOX-loaded counterparts had almost the same toxicity as free DOX to cancer cells. Therefore, the developed multifunctional materials can be used as promising drug controlled delivery platforms for cancer therapy.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Binding energy. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haratipour, Pouya; Minard, Corinne; Nakhjiri, Maryam; Negahbani, Amirsoheil; Kashemirov, Boris A.; McKenna, Charles E. published the artcile< New chirally modified bisphosphonates for synthesis of individual beta,gamma-CHX-deoxynucleotide diastereomers>, Quality Control of 2127-03-9, the main research area is Mitsunobu condensation phosphonate methylmandelate ester cytosine ethylbenzylamide preparation; nucleotide ethylbenzylamine phenylglycine hydrogenolysis phosphonate protecting group nitrobenzyl; synthon deoxynucleotide polymerase kinase enzyme active site; chiral bisphosphonates; dNTP probes; polymerase mechanism.

Individual diastereomers of CXY bisphosphonate analogs of dNTPs or NTPs are useful chem. stereoprobes to investigate interactions within the chiral active site environment of enzymes such as polymerases and kinases. We previously reported synthetic access to β,γ-CHX-dGTPs (X = F or Cl) via a bisphosphonate synthon with an (R)-Me mandelate auxiliary and have extended this approach to dTTP and dATP analogs. As removal of the chiral auxiliary by (Pd/C) hydrogenolysis is incompatible with the cytosine heterocycle and also with X = Br, we have now designed bisphosphonate synthons using (R)-(+)-α-ethylbenzylamine or Me (R)-(-)-phenylglycine auxiliaries and equipped with an o-nitrobenzyl ester protecting group allowing photochem. deprotection. These new synthons have made possible the first syntheses of individual dCTP and mono-bromo-substituted dNTP β,γ-CHX diastereomers.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Condensation reaction. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Quality Control of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ze; Li, Wenwei; Lu, Maolin; Bess, Julian Jr; Chao, Cara W.; Gorman, Jason; Terry, Daniel S.; Zhang, Baoshan; Zhou, Tongqing; Blanchard, Scott C.; Kwong, Peter D.; Lifson, Jeffrey D.; Mothes, Walther; Liu, Jun published the artcile< Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is .

Abstract: The HIV-1 envelope glycoprotein (Env) trimer, composed of gp120 and gp41 subunits, mediates viral entry into cells. Recombinant Env trimers have been studied structurally, but characterization of Env embedded in intact virus membranes has been limited to low resolution Here, we deploy cryo-electron tomog. and subtomogram averaging to determine the structures of Env trimers on aldrithiol-2 (AT-2)-inactivated virions in ligand-free, antibody-bound and CD4-bound forms at subnanometer resolution Tomog. reconstructions document mol. features consistent with high-resolution structures of engineered soluble and detergent-solubilized Env trimers. One of three conformational states previously predicted by smFRET was not observed by cryo-ET, potentially owing to AT-2 inactivation. We did observe Env trimers to open in situ in response to CD4 binding, with an outward movement of gp120-variable loops and an extension of a critical gp41 helix. Overall features of Env trimer embedded in AT-2-treated virions appear well-represented by current engineered trimers.

Nature Structural & Molecular Biology published new progress about 2127-03-9. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sikder, Amrita; Ray, Debes; Aswal, Vinod K.; Ghosh, Suhrit published the artcile< Supramolecular Assembly of a Molecularly Engineered Protein and Polymer>, Computed Properties of 2127-03-9, the main research area is supramol assembly protein polymer; conjugation; hydrogen bonds; polymers; proteins; self-assembly.

Programmable assembly of biomols. is a fast growing research area that aims to emulate nature’s elegance in creating numerous hierarchical self-assembled structures, which are responsible for unimaginably difficult biol. functions. Protein assembly is a particularly challenging task, owing to their structural diversity, conformational heterogeneity, and high mol. weight This article reveals the ability of a supramol. structure-directing unit (SSDU) to regulate the entropically favorable supramol. assembly of a covalently conjugated protein (bovine serum albumin (BSA)) to produce well-defined protein-decorated micelles with remarkably high thermal stability, suppression of the thermal denaturation of the protein, and retention of enzymic activity. Furthermore, a SSDU-appended thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) coassembles with the SSDU-BSA conjugate because, in both cases, assembly was primarily driven by specific mol. recognition between the SSDUs. However, the resulting supramol. protein-polymer conjugate exhibits distinctly different polymersome structure to that of the micellar particle produced by the protein-SSDU conjugate. In this case, the enzymic activity can be significantly suppressed above the lower critical solution temperature of supramolecularly conjugated PNIPAM, possibly due to collapse of the de-solvated polymer chains on the protein surface.

Chemistry – A European Journal published new progress about Bovine serum albumin Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process) (conjugates with 1,4,5,8-naphthalenetetracarboxylic diimide derivative). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Computed Properties of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Bo; Bi, Xiuru; Zhou, Jinbo; Li, Changming; Zhao, Peiqing; Meng, Xu published the artcile< Synthesis of Crystalline OMS-2 with Urea Hydrogen Peroxide and its Application in Aerobic Oxidation Reactions>, Category: pyridine-derivatives, the main research area is cryptomelane type manganese oxide preparation pore size crystallinity recyclability; alkane manganese oxide catalyst selective oxidation; ketone preparation; thiol manganese oxide catalyst selective oxidation; disulfide preparation.

Cryptomelane-type manganese oxide (OMS-2) was synthesized successfully using urea hydrogen peroxide (urea.H2O2) as the reductant in an acidic buffer solution As-prepared crystalline material was fully characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller method (BET), XPS, SEM (SEM) and high resolution transition electron microscopy(HRTEM). The results demonstrate that OMS-2 has nanofiber with short nanorod morphologies, very rich oxygen vacancy defected and more exposed crystal facets compared with ones synthesized with other H2O2-containing reductants. These unique properties made nanostructural OMS-2 an excellent heterogeneous catalyst in aerobic oxidation reactions, such as selective oxidation of mercaptan and oxygenation of alkylarenes.

ChemistrySelect published new progress about Crystallinity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Shuguang; Chen, Liang; Zhou, Xiaojun; Sun, Ping; Fu, Liwen; You, Yanling; Xu, Man; You, Zhengwei; Kai, Guoyin; He, Chuanglong published the artcile< Tumor-targeted biodegradable multifunctional nanoparticles for cancer theranostics>, Category: pyridine-derivatives, the main research area is tumor targeting biodegradable multifunctional nanoparticle cancer theranostic.

Mesoporous silica nanoparticles (MSN) attract extensive attention in area of cancer diagnosis and therapy because of their controllable nanostructures, easy surface modification and stable synthesis methods. However, their biodegradability was still controversial. This work explored the degradation effect of a type of biodegradable MSN (bMSN) in different environments and simultaneously endowed it with imaging functions and high-efficiency targeting effect on cancer cell, thus forming a multifunctional biodegradable drug carrier (bMSN-ss-GABA) for cancer theranostics. The bovine serum albumin-based Gd/Au complex (BSA-Gd/Au) was wrapped on the surface of bMSN through disulfide linkage, acting as contrast agent for magnetic resonance (MR) and fluorescence imaging, and then folate (FA), whose receptor (FR) is overexpressed in KB human oral epidermoid carcinoma cells, was modified on the nanocarriers as a targeting ligand. TEM revealed the degradation process of bMSN and a series of characterization methods verified the successful construction of bMSN-ss-GABA. Doxorubicin hydrochloride (DOX) loaded bMSN-ss-GABA (DOX@bMSN-ss-GABA) was proved with redox-responsiveness, thereby triggering rapid drug release under specific tumor microenvironment of high glutathione concentration Further, the excellent imaging capability was also fully inspected. What’s more, the results of endocytosis and tumor growth inhibition of DOX@bMSN-ss-GABA demonstrated the highly effective targeting effect of hybrid nanocarriers. Therefore, the prepared DOX@bMSN-ss-GABA might be used as a promising nanotheranostic agent for KB human oral epidermoid carcinoma.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Campos, Nathalia R.; Simosono, Cintia A.; Landre Rosa, Iara M.; da Silva, Rafaela M. R.; Doriguetto, Antonio C.; do Pim, Walace D.; Gomes Simoes, Tatiana R.; Valdo, Ana Karoline S. M.; Martins, Felipe T.; Sarmiento, Charlie V.; Nunes, Wallace C.; Guedes, Guilherme P.; Pedroso, Emerson F.; Pereira, Cynthia L. M.; Stumpf, Humberto O.; Lloret, Francesc; Julve, Miguel; Marinho, Maria Vanda published the artcile< Building-up host-guest helicate motifs and chains: a magneto-structural study of new field-induced cobalt-based single-ion magnets>, Electric Literature of 2127-03-9, the main research area is cobalt chloride hexahydrate dipyridyldisulfide magnetostructural correlation single ion magnet.

In this work, we present the synthetic pathway, a refined structural description, complete solid-state characterization and the magnetic properties of four new cobalt(II) compounds of formulas [Co(H2O)6][Co2(H2mpba)3]·2H2O·0.5dmso (1), [Co(H2O)6][Co2(H2mpba)3]·3H2O·0.5dpss (2), [Co2(H2mpba)2(H2O)4]n·4nH2O (3), and [Co2(H2mpba)2(CH3OH)2(H2O)2]n·0.5nH2O·2ndpss (4) [dpss = 2,2′-dipyridyldisulfide and H4mpba = 1,3-phenylenebis(oxamic) acid], where 2 and 4 were obtained from [Co(dpss)Cl2] (Pre-I) as the source of cobalt(II). All four compounds are air-stable and were prepared under ambient conditions. 1 and 2 were obtained from a slow diffusion method [cobalt(II) : H2mpba2- molar ratio used 1 : 1] and their structures are made up of [Co2(H2mpba)3]2- anionic helicate units and [Co(H2O)6]2+ cations, exhibiting supramol. three-dimensional structures. Interestingly, a supramol. honeycomb network between the helicate units interacting with each other through R22(10) type hydrogen bonds occurs in 2 hosting one co-crystallized dpss mol. On the other hand, for the first time, linear (3) and zigzag (4) cobalt(II) chains were isolated by slow evaporation of stirred solutions of mixed solvents with cobalt(II) : H2mpba2- in 1 : 2 molar ratio at room temperature Magnetic measurements of Pre-I revealed a quasi magnetically isolated S = 3/2 spin state with a significant second-order spin-orbit contribution as expected for tetrahedrally coordinated cobalt(II) ions. The anal. of the variable temperature static (dc) magnetic susceptibility data through first- (1 and 3) and second-order spin-orbit coupling models (2 and 4) reveals the presence of magnetically non-interacting high-spin cobalt(II) ions with easy-axis (1 and 4)/easy-plane magnetic anisotropies (2 and 4) with low rhombic distortions. Dynamic (ac) magnetic measurements for Pre-I and 1-4 below 8.0 K show that they are examples of field-induced Single-Ion Magnets (SIMs).

Dalton Transactions published new progress about Alternating current. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Electric Literature of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiao, Zhiwei; Wang, Lu; Wei, Junjie; Ran, Chongzhao; Liang, Steven H.; Shang, Jingjie; Chen, Guang-Ying; Zheng, Chao published the artcile< Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds>, Application In Synthesis of 2127-03-9, the main research area is aryldisulfide hydroxyphthalimide ester preparation ruthenium photocatalyst decarboxylative coupling; benzenethiosulfonate hydroxyphthalimide ester preparation ruthenium photocatalyst decarboxylative coupling; aryl thioether preparation.

A novel method was established for the construction of C-S bonds using redox-active esters with disulfides in the presence of Ru-photoredox catalyst. This method exhibited remarkable functional group tolerance across a wide scope of substrates. Under mild conditions, a structurally diverse array of aryl alkyl sulfides was successfully and efficiently obtained through decarboxylative cross-coupling.

Chemical Communications (Cambridge, United Kingdom) published new progress about Decarboxylation catalysts (photochem.). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Canakci, Mine; Singh, Khushboo; Munkhbat, Oyuntuya; Shanthalingam, Sudarvili; Mitra, Ankita; Gordon, Mallory; Osborne, Barbara A.; Thayumanavan, S. published the artcile< Targeting CD4+ Cells with Anti-CD4 Conjugated Mertansine-Loaded Nanogels>, Related Products of 2127-03-9, the main research area is tumor antitumor T cell antibody CD4 mertansine.

CD4+ T lymphocytes play an important role in controlling many malignancies. The modulation of CD4+ T cells through immunomodulatory or cytotoxic drugs could change the course of disease progression for disorders such as autoimmunity, immunodeficiency, and cancer. Here, we demonstrate that anti-CD4 conjugated polymeric nanogels can deliver a small mol. cargo to primary CD4+ T cells and a CD4high T cell lymphoma. The antibody conjugation not only increased the uptake efficiency of the nanogel (NG) by CD4+ T cells but also decreased the non-specific uptake of the NG by CD4- lymphocytes. For T lymphoma cell lines, the mertansine-loaded conjugate displayed a dose-dependent cell growth inhibition at 17 ng/mL antibody concentration On the other hand, antibody-drug conjugate (ADC)-type formulation of the anti-CD4 reached similar levels of cell growth inhibition only at the significantly higher concentration of 1.8μg/mL. NG and antibody conjugates have the advantage of carrying a large payload to a defined target in a more efficient manner as it needs far less antibody to achieve a similar outcome.

Biomacromolecules published new progress about Antibodies and Immunoglobulins Role: BPN (Biosynthetic Preparation), PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses) (mertansine-polymer conjugates). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem