Category: 2127-03-9

Nie, Fang-Yuan; Cai, Yi-Ping; Song, Qin-Hua published the artcile< Visible Light-Driven Decarboxylative Alkylation of Aldehydes via Electron Donor-Acceptor Complexes of Active Esters>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is quinoline pyridine ketone preparation green chem; pyridinaldehyde quinolinaldehyde decarboxylative alkylation photochem.

In this paper, authors have developed photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes. The photochem. reactions are initiated via photoinduced single electron transfer from triethylamine to N-hydroxyphthalimide esters in electron donor-acceptor complexes. This photochem. method can achieve to translate 15 pyridinaldehydes and 11 2-quinolinaldehydes to the corresponding ketones. Furthermore, this strategy can also achieve two other transformations, disulfanes to aryl sulfides and a styrene sulfone to the alkyl-substituted alkene.

Journal of Organic Chemistry published new progress about Aryl aldehydes, heteroaryl Role: RCT (Reactant), RACT (Reactant or Reagent). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duran-Mota, Jose Antonio; Yani, Julia Quintanas; Almquist, Benjamin D.; Borros, Salvador; Oliva, Nuria published the artcile< Polyplex-Loaded Hydrogels for Local Gene Delivery to Human Dermal Fibroblasts>, Application In Synthesis of 2127-03-9, the main research area is polyplex hydrogel fibroblast mRNA wound dressing; gene delivery; human dermal fibroblasts; hydrogel; nanoparticles; poly(β-amino ester)s; polyethylene glycol; skin; wound healing.

Impaired cutaneous healing leading to chronic wounds affects between 2 and 6% of the total population in most developed countries and it places a substantial burden on healthcare budgets. Current treatments involving antibiotic dressings and mech. debridement are often not effective, causing severe pain, emotional distress, and social isolation in patients for years or even decades, ultimately resulting in limb amputation. Alternatively, gene therapy (such as mRNA therapies) has emerged as a viable option to promote wound healing through modulation of gene expression. However, protecting the genetic cargo from degradation and efficient transfection into primary cells remain significant challenges in the push to clin. translation. Another limiting aspect of current therapies is the lack of sustained release of drugs to match the therapeutic window. Herein, we have developed an injectable, biodegradable and cytocompatible hydrogel-based wound dressing that delivers poly(β-amino ester)s (pBAEs) nanoparticles in a sustained manner over a range of therapeutic windows. We also demonstrate that pBAE nanoparticles, successfully used in previous in vivo studies, protect the mRNA load and efficiently transfect human dermal fibroblasts upon sustained release from the hydrogel wound dressing. This prototype wound dressing technol. can enable the development of novel gene therapies for the treatment of chronic wounds.

ACS Biomaterials Science & Engineering published new progress about Fibroblast. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Hongyan; Zhao, Qinfu; Wang, Xiudan; Mao, Yuling; Chen, Caishun; Gao, Yikun; Sun, Changshan; Wang, Siling published the artcile< Multi-stimuli responsive mesoporous silica-coated carbon nanoparticles for chemo-photothermal therapy of tumor>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is mesoporous silica carbon nanoparticle delivery chemophotothermal therapy cancer; Carbon dots; Chemo-photothermal synergistic therapy; Controlled release; Mesoporous silica-coated mesoporous carbon; Stimuli-response.

In this work, a traceable dual-porous mesoporous silica-coated mesoporous carbon nanocomposite with high drug loading capacity and high photothermal conversion efficiency (30.5%) was successfully prepared Based on the nanocomposite, a pH/redox/near IR multi-stimuli responsive drug delivery system was constructed to realize the accurate drug delivery, drug controlled release and chemo-photothermal synergistic antitumor therapy. MCN@Si was used as a vehicle to load doxorubicin with a high drug loading efficacy of 48.2% and a NIR absorbance agent for photothermal therapy and NIR thermal imaging. Carbon dots with proper size were covalently attached to the surface of MCN@Si via disulfide bonds to block the mesopores, preventing DOX premature release from DOX/MCN@Si-CDs. DOX was rapidly released at the condition of low pH and high GSH concentration due to the breakage of disulfide bonds and protonation of DOX. Moreover, the local hyperthermia generated by MCN@Si-CDs under NIR irradiation could not only directly kill cells, but also accelerate DOX release and enhance cells sensitivity and permeability. Two-dimensional cells and three-dimensional tumor spheroids assays illustrated that DOX/MCN@Si-CDs + NIR group exhibited thermochemotherapy synergistic treatment effect and combination index was 0.378. All the results demonstrated that DOX/MCN@Si-CDs is a traceable multi-stimuli responsive nanodelivery system and can achieve efficient chemo-photothermal synergistic antitumor therapy.

Colloids and Surfaces, B: Biointerfaces published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiao, Yue; Li, Yang; Zhang, Bohan; Li, Hui; Cheng, Zehong; Shi, Jianqiao; Xiong, Jing; Bai, Yugang; Zhang, Ke published the artcile< Functionalizable, Side Chain-Immolative Poly(benzyl ether)s>, Related Products of 2127-03-9, the main research area is selfimmolative polybenzylether.

Herein, we report a poly(benzyl ether)-based self-immolative polymer (SIP) with pendant pyridine disulfide groups. Cleavage of the side-chain disulfides leads to the formation of phenolates, which initiate depolymerization from the side chain. Due to the higher d. of the disulfide groups compared to that of the chain-end-capping group, which normally is responsible for initiating depolymerization of SIPs, the side chain-immolative polymer (ScIP) can be readily degraded in the solid state where the mobility of polymer chains is substantially limited. The ScIP was also further modified through the thiol-disulfide exchange reaction to prepare ScIP-g-poly(ethylene glycol) graft polymers and organogels, which were also able to undergo complete reductive self-immolative degradation

ACS Macro Letters published new progress about Depolymerization. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mathuri, Ashis; Pramanik, Milan; Parida, Amarchand; Mal, Prasenjit published the artcile< Disulfide metathesis via sulfur···iodine interaction and photoswitchability>, Synthetic Route of 2127-03-9, the main research area is unsym disulfide preparation; sym disulfide cross metathesis reaction photoswitchable.

Herein, the synthesis of unsym. diaryl disulfides RSSR1 (R = 2-MeC6H4, furan-2-ylmethyl, pyridin-2-yl, etc., R1 = CH2CHMe2, cyclohexyl, 4-ClC6H4, etc.) from two sym. disulfides RSSR and R1SSR1 via a cross-metathesis reaction which was controlled by a weak sulfur···iodine (S···I) interaction is reported. The unsym. disulfides were stable in acetonitrile solution in the presence of N-iodosuccinimide (NIS), and were found to be reversibly photoswitchable to the sym. disulfides under visible light irradiation

Organic & Biomolecular Chemistry published new progress about Aromatic compounds, disulfides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Pengpeng; Chen, Chuan; Li, Shubai published the artcile< Selectfluor-initiated cyanation of disulfides to thiocyanates>, Electric Literature of 2127-03-9, the main research area is disulfide trimethylsilyl cyanide Selectfluor promoter cyanation green chem; thiocyanate preparation.

A Selectfluor-initiated cyanation of disulfides to thiocyanates was developed. In this process, Selectfluor was employed as the oxidant and trimethylsilyl cyanide was used as the cyanation reagent. It provides an eco-friendly and simple way to synthesize the thiocyanates.

Journal of Chemical Research published new progress about Cyanation. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Electric Literature of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mangala Prasad, Vidya; Leaman, Daniel P.; Lovendahl, Klaus N.; Croft, Jacob T.; Benhaim, Mark A.; Hodge, Edgar A.; Zwick, Michael B.; Lee, Kelly K. published the artcile< Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice>, Computed Properties of 2127-03-9, the main research area is HIV1 virions structural variation Env Gag glycosylation gp120; Gag-Env interaction; HIV Env glycoprotein; HIV assembly; broadly neutralizing antibody; cryo-electron microscopy; cryo-electron tomography; hydrogen/deuterium-exchange mass spectrometry; sub-tomogram averaging; vaccine design; virus structure.

HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here, we used cryo-electron tomog. to analyze Env in mature and immature HIV-1 particles. Immature particles showed distinct Env positioning relative to the underlying Gag lattice, providing insights into long-standing questions about Env incorporation. A 9.1-Å sub-tomogram-averaged reconstruction of virion-bound Env in conjunction with structural mass spectrometry revealed unexpected features, including a variable central core of the gp41 subunit, heterogeneous glycosylation between protomers, and a flexible stalk that allows Env tilting and variable exposure of neutralizing epitopes. Together, our results provide an integrative understanding of HIV assembly and structural variation in Env antigen presentation.

Cell (Cambridge, MA, United States) published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Computed Properties of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Dan-Yang; Si, Yubing; Guo, Wei; Fu, Yongzhu published the artcile< Long Cycle Life Organic Polysulfide Catholyte for Rechargeable Lithium Batteries>, SDS of cas: 2127-03-9, the main research area is rechargeable lithium battery organic polysulfide catholyte; dipyridyl polysulfide; lithium batteries; molecular dynamic simulations; organosulfide; ultra performance liquid chromatographyquadrupole time‐of‐flight‐mass spectrometry (UPLC‐QTof‐MS).

Herein, a spectrum of dipyridyl polysulfides (Py2Sx, 3 ≤ x ≤ 8) is prepared in electrolyte by a one-pot synthesis method from dipyridyl disulfide (Py2S2) and elemental sulfur. It renders up to seven dipyridyl polysulfides (i.e., Py2S3, Py2S4, Py2S5, Py2S6, Py2S7, and Py2S8) which show fully reversible electrochem. behavior in lithium batteries. In the discharge, the initial lithiation occurs at 2.45 V leading to the breakage of Sα-Sβ bonds in Py2Sx and formation of lithium 2-pyridinethiolate, in which lithium is coordinated in between N and S atoms. The left sulfur species act as elemental sulfur, showing two voltage plateaus at 2.3 and 2.1 V. The mol. dynamics simulations show the attraction between pyridyl groups and lithium polysulfides/sulfide via N···Li···S bonds, which enable good retention of soluble discharge products within electrodes and stable cycling performance. In the recharge, low-order Py2Sx (e.g., Py2S3, Py2S4, and Py2S5) remain as the charged products. The mixture catholyte exhibits superlong cycle life at 1C rate with 1200 cycles and 70.5% capacity retention.

Advanced Science (Weinheim, Germany) published new progress about Aqueous solutions, electrolyzed water. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Man; Luo, Yan; Zeng, Weijia; Yang, Xiaoqing; Chen, Tingting; Zhang, Lulu; He, Xiaoyan; Yi, Xiuguang; Li, Yongxiu; Yi, Xiaoqing published the artcile< A co-delivery system based on a dimeric prodrug and star-shaped polymeric prodrug micelles for drug delivery>, Application of C10H8N2S2, the main research area is paclitaxel reduced glutathione dimeric polymeric prodrug delivery system; dimeric prodrug; drug delivery; high drug loading; polymeric prodrug micelles; reduction-sensitive.

Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle-based drug delivery systems of chemotherapy. Here, the redox-responsive star-shaped polymeric prodrug (PSSP) and the dimeric prodrug of paclitaxel (PTX) were prepared Then the dimeric prodrug of PTX (diPTX, diP) was loaded into the core of the star-shaped polymeric prodrug micelles of PSSP by hydrophobic interaction forming the redox-responsive prodrug micelles of diPTX@PSSP for intracellular drug release in tumor cells. The hydrodynamic diameter of diPTX@PSSP nanoparticles was 114.3 nm ± 2.1 (PDI = 0.219 ± 0.016), and the micelles had long-term colloidal stability and the drugloading content (DLC) of diPTX and PTX is 16.7 and 46.9%, resp. The prepared micelles could broke under the reductive microenvironment within tumor cells, as a result, the dimeric prodrug of diP and polymeric prodrug micelles of PSSP were rapidly disassembled, leading to the rapid release of intracellular drugs. In vitro release studies showed that under the condition of reduced glutathione (GSH) (10 mM), the release of PTX was significantly accelerated with approx. 86.6% released within 21 h, and the released PTX in cytoplasm could promote the disintegration of microtubules and induce cell apoptosis. These results indicated that the new type of this reduction-sensitive nanodrug delivery system based on dimeric prodrug@polymeric prodrug micelles would be a promising technol. in chemotherapy.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Cytotoxicity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Yechen; Li, Yang; Gao, Hang; Jiang, Bo; Zhang, Xiaodan; Li, Xiao; Wu, Qiong; Liang, Zhen; Zhang, Lihua; Zhang, Yukui published the artcile< Cleavable hydrophobic derivatization strategy for enrichment and identification of phosphorylated lysine peptides>, Synthetic Route of 2127-03-9, the main research area is lysine phosohopeptide derivatization; Cleavable hydrophobic derivatization; Liquid chromatography–tandem mass spectrometry; N-Phosphorylation; Phosphorylated lysine peptides; Proteomics.

Because of structural flexibility and acid lability, the identification of phosphorylated lysine (pLys) peptides is a great challenge. The authors report here a cleavable hydrophobic derivatization (CHD) strategy for the enrichment and identification of pLys peptides. First, 2,5-dioxopyrrolidin-1-yl-3-(decyldithio)propanoate was synthesized to react with dephosphorylated lysine peptides, and then the derived peptides were captured by a C18 column, followed by cleavage of the hydrophobic chain, with the specific label left on the target peptides for further identification. By CHD, the enrichment of pLys peptides from interfering peptides (1:1000 mass ratio) was achieved. Furthermore, CHD was applied to screen the pLys targets from Escherichia coli lysates, and 39 pLys sites from 35 proteins were identified. Gene Ontol. (GO) anal. showed that these proteins played vital roles in catabolism, metabolism, biogenesis, and biosynthetic processes. All these results demonstrate that CHD might pave the way for comprehensive profiling of the pLys proteome.

Analytical and Bioanalytical Chemistry published new progress about Escherichia coli. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem