Category: 2127-03-9

Fu, Bo; Wang, Xiaobei; Chen, Zhengda; Jiang, Nan; Guo, Zhigang; Zhang, Yuhui; Zhang, Shaopeng; Liu, Xiankun; Liu, Li published the artcile< Improved myocardial performance in infarcted rat heart by injection of disulfide-cross-linked chitosan hydrogels loaded with basic fibroblast growth factor>, Reference of 2127-03-9, the main research area is bFGF cardioprotective disulfide crosslinked chitosan hydrogel myocardial infarction.

Myocardial infarction (MI) has been considered as the leading cause of cardiovascular-related deaths worldwide. Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that promotes angiogenesis after MI; however, it has poor clin. efficacy due to proteolytic degradation, low drug accumulation, and severe drug-induced side effects. In this study, an injectable disulfide-cross-linked chitosan hydrogel loaded with bFGF was prepared via a thiol-disulfide exchange reaction for MI treatment. The thiol-disulfide exchange reaction between pyridyl disulfide-modified carboxymethyl chitosan (CMCS-S-S-Py) and reduced BSA (rBSA) was carried out under physiol. conditions (37 °C and pH 7.4). The mech. properties of the disulfide-cross-linked chitosan hydrogel were evaluated based on the molar ratio of the pyridyl disulfide groups of CMCS-S-S-Py and the thiol groups of rBSA. The disulfide-cross-linked chitosan hydrogel showed good swelling performance, rapid glutathione-triggered degradation behavior and well-defined cell proliferation towards NIH 3T3 fibroblast cells. In the process of establishing a rat MI model, the squeezing heart method was used to make the operation more accurate and the mortality of rats was decreased by using a ventilator. The disulfide-cross-linked chitosan hydrogel loaded with bFGF (bFGF-hydrogel) was injected into a peri-infarcted area of cardiac tissue immediately following MI. Echocardiog. demonstrated that the left ventricular functions were improved by the bFGF-hydrogel after 28 days of treatment. Histol. results revealed that the hydrogel significantly reduced the fibrotic area of MI, and this was further improved by the bFGF-hydrogel treatment. TUNEL and immunohistochem. staining results showed that the bFGF-hydrogel had a more synergistic effect on antiapoptosis and proangiogenesis than using either bFGF or the hydrogel alone.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Angiogenesis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Reference of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iwata, Takahiro; Hirose, Hisaaki; Sakamoto, Kentarou; Hirai, Yusuke; Arafiles, Jan Vincent V.; Akishiba, Misao; Imanishi, Miki; Futaki, Shiroh published the artcile< Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides>, Formula: C10H8N2S2, the main research area is cervical cancer Fc binding ACAL peptide L17E IgG; antibodies; intracellular delivery; liquid droplet; liquid-liquid phase separation (LLPS); peptides.

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E trimer [FcB(L17E)3] was designed for IgG (IgG) delivery into cells. Particle-like liquid droplets were generated by mixing Alexa Fluor 488 labeled IgG (Alexa488-IgG) with FcB(L17E)3. Droplet contact with the cellular membrane led to spontaneous influx and distribution of Alexa488-IgG throughout cells in serum containing medium. Involvement of cellular machinery accompanied by actin polymerization and membrane ruffling was suggested for the translocation. Alexa488-IgG neg. charges were crucial in liquid droplet formation with pos. charged FcB(L17E)3. Binding of IgG to FcB(L17E)3 may not be necessary. Successful intracellular delivery of Alexa Fluor 594-labeled anti-nuclear pore complex antibody and anti-mCherry-nanobody tagged with supernegatively charged green fluorescence protein allowed binding to cellular targets in the presence of FcB(L17E)3.

Angewandte Chemie, International Edition published new progress about Blood serum. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Conejos-Sanchez, I.; Gallon, E.; Nino-Pariente, A.; Smith, J. A.; De la Fuente, A. G.; Di Canio, L.; Pluchino, S.; Franklin, R. J. M.; Vicent, M. J. published the artcile< Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders>, Related Products of 2127-03-9, the main research area is polyornithine siRNA polyplex central nervous system disorder.

Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on multimol. delivery vehicles are concentrated on overcoming the difficulties in delivery of small interfering (si)RNA to target tissues, which include anatomical accessibility, slow diffusion, safety concerns, and the requirement for specific cell uptake within the unique environment of the CNS. The present work addressed these challenges through the implementation of polyornithine derivatives in the construction of polyplexes used as non-viral siRNA delivery vectors. Physicochem. and biol. characterization revealed biodegradability and biocompatibility of our polyornithine-based system and the ability to silence gene expression in primary oligodendrocyte progenitor cells (OPCs) effectively. In summary, the well-defined properties and neurol. compatibility of this polypeptide-based platform highlight its potential utility in the treatment of CNS disorders.

Nanoscale published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shahsavari, Hamid R.; Babadi Aghakhanpour, Reza; Biglari, Abbas; Niazi, Maryam; Mastrorilli, Piero; Todisco, Stefano; Gallo, Vito; Lalinde, Elena; Moreno, M. Teresa; Gimenez, Nora; Halvagar, Mohammad Reza published the artcile< C(sp2)-C(sp2) Reductive Elimination from a Diarylplatinum(II) Complex Induced by a S-S Bond Oxidative Addition at Room Temperature>, Product Details of C10H8N2S2, the main research area is arylplatinum benzothiazolethiolate pyridinethiolate preparation crystal structure; crystal structure diarylplatinum benzothiazolethiolate pyridinethiolate dinuclear platinum lantern complex; mol structure diarylplatinum benzothiazolethiolate pyridinethiolate dinuclear platinum lantern complex; dinuclear platinum lantern complex preparation crystal structure; diarylplatinum complex oxidative addition benzothiazolethiolate pyridinethiolate.

The synthesis and characterization of three six-coordinated Pt(IV) complexes [Pt(Ar)2(S[symbol omitted]N)2] (S[symbol omitted]N = Sbt, benzothiazole-2-thiolate, Ar = p-MeC6H4 (1a), C6F5 (1b); S[symbol omitted]N = Spy, 2-pyridinethiolate, Ar = p-MeC6H4 (1c)) is described. Of these, 1a undergoes, at room temperature and within 18 h, a remarkable C-C reductive elimination process between the aryl ligands to give, as the final products, the stable binuclear lantern complex [Pt2(Sbt)4] (2a) and 4,4′-dimethylbiphenyl. Differently from 1a, solutions of 1b,c are indefinetively stable up to 60° and do not undergo reductive elimination. Complexes 1a-c and 2a were characterized by IR and NMR spectroscopy, high-resolution mass spectrometry, and single-crystal x-ray crystallog. (1b,c and 2a). 1H-19F HOESY experiments on 1b demonstrated the presence of a through-space coupling between proximal F and H atoms of the mol. that are separated by six bonds but are in close spatial proximity.

Organometallics published new progress about Crystal structure. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ran, Wei; Liu, Xiaoyu; Chang, Lu; Cai, Ying; Zheng, Chao; Liu, Jia; Li, Yaping; Zhang, Pengcheng published the artcile< Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer>, Quality Control of 2127-03-9, the main research area is self assembling mertansine prodrug nanoparticle drug delivery system; Chemotherapy; Prodrug; Self-assembly; Supramolecular; Triple-negative breast cancer.

Metastatic triple-neg. breast cancer is one of the most devastating cancer types. Systemic chemotherapy is necessary, but its clin. performance is largely limited by severe side effects. Herein, we report a mertansine prodrug, which could self-assemble into spherical nanoparticles in water and readily convert into active mertansine at the presence of glutathione. The self-assembling mertansine prodrugs (SAMPDs) entered cancer cells via a caveolae-mediated pathway and exhibited potent cytotoxicity. The self-delivering SAMPDs did not cause hemolysis, and more importantly increased maximum tolerated dose (MTD) of mertansine by 8 folds via reducing free mertansine exposure in most of the major organs. SAMPDs improved intratumoral drug exposure and showed dose-dependent antitumor activity. When dosed at MTD, SAMPDs inhibited primary tumor growth and pulmonary metastasis by 80% and 95%, while mertansine dosed at MTD only reduced primary tumor growth and metastasis by <50% and 60%, resp. Our results reveal the mechanism of in vivo biotransformation of self-assembling prodrug and highlight the unique advantages of self-assembling prodrug strategy in improving the efficacy and safety of chemotherapy. Journal of Controlled Release published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Quality Control of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Guangyu; Liu, Xiaoman; Zhou, Pei; Xu, Zhijun; Hegazy, Mohammad; Huang, Xin; Huang, Yudong published the artcile< The construction of thiol-functionalized DNAsomes with small molecules response and protein release>, HPLC of Formula: 2127-03-9, the main research area is thiol functionalized DNAsome protein release drug delivery system; Pickering emulsion; Polymeric capsule; Self-assembly.

In this work, a poly(N-isopropylacrylamide) polymer (PNIPAAm) was prepared via the photoinduced reversible addition-fragmentation chain transfer (RAFT) polymerization using Ru(bpy)3Cl2·6H2O as photoinitiator. The design and spontaneous assembly of thiol-functionalized DNA-Thiol/PNIPAAm polymeric capsule (DNAsomes) by water-in-oil Pickering emulsion method and effective response with small mols. (Sybr green and phenanthrene) were described. The intermediate product, DNA-Thiol/PNIPAAm conjugates and DNAsomes were characterized by using 1H NMR, dynamic light scattering (DLS), SEM, TEM and UV-vis methods. The obtained results indicated that DNA-Thiol/PNIPAAm constructs assembled in a Pickering emulsion could produce DNA-based spherical DNAsomes with typically 3.3-267.7μm in diameter The DNAsomes showed a vesicle formation approx. 2μm in diameter, resulting in phenanthrene mol. intercalating with DNAsomes. The phenomenon indicated that the DNA-Thiol/PNIPAAm conjugates may have potential applications in recognition polycyclic aromatic hydrocarbon mols. The membrane of the DNAsomes could effective response toward small mols. such as Sybr green or phenanthrene, and DNAsomes has release capability of protein (BSA) under reductive agent glutathione (GSH). Our results highlight the potential of integrating aspects of supramol. and polymer chem. into the design and construction of DNA-polymeric capsule, guest mol. encapsulation, control delivery of drugs, recognition organic polycyclic aromatic hydrocarbon mols. and gene-directed capsule synthesis.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about Bovine serum albumin Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, HPLC of Formula: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiao, Chen; Obst, Franziska; Geisler, Martin; Che, Yunjiao; Richter, Andreas; Appelhans, Dietmar; Gaitzsch, Jens; Voit, Brigitte published the artcile< Reversible Protein Capture and Release by Redox-Responsive Hydrogel in Microfluidics>, Product Details of C10H8N2S2, the main research area is protein capture redox responsive hydrogel microfluidics; disulfide bonds; hydrogels; mechanical properties; microfluidics; protein capture and release; redox-responsive; swelling behaviors.

Stimuli-responsive hydrogels have a wide range of potential applications in microfluidics, which has drawn great attention. Double crosslinked hydrogels are very well suited for this application as they offer both stability and the required responsive behavior. Here, we report the integration of poly(N-isopropylacrylamide) (PNiPAAm) hydrogel with a permanent crosslinker (N,N′-methylenebisacrylamide, BIS) and a redox responsive reversible crosslinker (N,N′-bis(acryloyl)cystamine, BAC) into a microfluidic device through photopolymerization Cleavage and re-formation of disulfide bonds introduced by BAC changed the crosslinking densities of the hydrogel dots, making them swell or shrink. Rheol. measurements allowed for selecting hydrogels that withstand long-term shear forces present in microfluidic devices under continuous flow. Once implemented, the thiol-disulfide exchange allowed the hydrogel dots to successfully capture and release the protein bovine serum albumin (BSA). BSA was labeled with rhodamine B and functionalized with 2-(2-pyridyldithio)-ethylamine (PDA) to introduce disulfide bonds. The reversible capture and release of the protein reached an efficiency of 83.6% in release rate and could be repeated over 3 cycles within the microfluidic device. These results demonstrate that our redox-responsive hydrogel dots enable the dynamic capture and release of various different functionalized (macro)mols. (e.g., proteins and drugs) and have a great potential to be integrated into a lab-on-a-chip device for detection and/or delivery.

Polymers (Basel, Switzerland) published new progress about Bovine serum albumin Role: PEP (Physical, Engineering or Chemical Process), PUR (Purification or Recovery), PROC (Process), PREP (Preparation) (rhodamine B and PDA-labeled). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xuefu; Ru, Shaoguo; Tian, Hua; Zhang, Suqiu; Lin, Zhenxian; Gao, Ming; Wang, Jun published the artcile< Combined exposure to environmentally relevant copper and 2,2-dithiobis-pyridine induces significant reproductive toxicity in male guppy (Poecilia reticulata)>, Application of C10H8N2S2, the main research area is Poecilia reproductive toxicity dithiobis pyridine copper risk assessment; (PS)(2); Co-exposure; Cu; Ecological safety; Guppy (Poecilia reticulata); Impaired reproduction.

Metal pyrithiones (MePTs), the most widely used biocides in antifouling paints (AFs) coated on the hulls, are usually used in combination with Cu-containing substances. In the aquatic environment, 2,2-dithiobis-pyridine ((PS)2), the main degradation product of MePTs, and Cu usually coexist. However, their combined impacts on aquatic organisms are unclear. This study exposed male guppy (Poecilia reticulata) to an environmentally realistic concentration of Cu (10μg/L) alone or Cu (10μg/L) combined with 20, 200, and 2000 ng/L (PS)2 to explore their combined reproductive toxicity. The results showed that co-exposure to Cu and (PS)2 increased Cu accumulation in the fish body in a dose-dependent manner and induced obvious spermatozoon apoptosis and necrosis, which was mediated by the peroxidation and caspase activation. Compared to Cu alone, co-exposure to Cu and 200, 2000 ng/L (PS)2 significantly decreased the testosterone level and collapsed spermatogenesis, and depressed male sexual interest and mating behavior were observed in three co-exposure groups. Moreover, co-exposure to Cu and (PS)2 increased the disturbance on cyp19a and cyp19b transcription and suppressed the “”display”” reproductive behavior. Eventually, co-exposure to Cu and (PS)2 caused male reproductive failure. Therefore, the concurrence of Cu and (PS)2 induced significant reproductive toxicity in male guppies and would threaten the sustainability of fish populations. Considering the extensive usage of MePTs products in the AFs, their ecol. risk warrants more evaluation.

Science of the Total Environment published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (cyp19a). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheng, Yin-Jia; Qin, Si-Yong; Ma, Yi-Han; Chen, Xiao-Sui; Zhang, Ai-Qing; Zhang, Xian-Zheng published the artcile< Super-pH-Sensitive Mesoporous Silica Nanoparticle-Based Drug Delivery System for Effective Combination Cancer Therapy>, Product Details of C10H8N2S2, the main research area is peptide doxorubicin silica nanoparticle tumor antitumor; charge-reversal; combinational tumor therapy; mesoporous silica nanoparticles; multifunctional peptide; redox-sensitive drug release.

A multifunctional nanoplatform based on mesoporous silica nanoparticles (MSNs) was developed for combinational tumor therapy. Doxorubicin (DOX) was chosen as an antitumor drug and loaded into mesopores of MSNs via phys. absorption. Then, a tumor-targeted fusion peptide conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced to the surface of MSNs as super-pH-sensitive nanovalves through disulfide linkages. The BSA adsorption assay confirmed the charge-reversal property of MSN-ss-DTPP&DTCPP nanoparticles at slightly acidic condition (pH 6.8) and superior stability in physiol. environment (pH 7.4). According to the drug release research, both glutathione (GSH) and acidic condition are required for the accelerated drug release from DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies demonstrated the significantly reinforced tumor cellular uptake efficiency and mitochondrial disruption ability of DOX@MSN-ss-DTPP&DTCPP nanoparticles in tumor environment, in which DOX@MSN-ss-DTPP&DTCPP nanoparticles exhibited the preferred cytotoxicity toward αvβ3-pos. human cervical carcinoma (HeLa) cells. We believe that the multifunctional dual-stimuli-sensitive MSN could provide an effective strategy for combinational tumor therapy.

ACS Biomaterials Science & Engineering published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiao, Xuan; Wang, Kewei; Zong, Qingyu; Tu, Yalan; Dong, Yansong; Yuan, Youyong published the artcile< Polyprodrug with glutathione depletion and cascade drug activation for multi-drug resistance reversal>, HPLC of Formula: 2127-03-9, the main research area is polydisulfide prodrug glutathione depletion multidrug resistance reversal; Glutathione response; Multidrug resistance; poly(disulfide).

High intracellular glutathione (GSH) levels play an important role in multidrug resistance (MDR) in cancer cells. It remains challenging to develop a drug delivery system that is simultaneously capable of GSH depletion and drug activation for multidrug resistance reversal. Herein, we designed a polyprodrug (denoted as PSSD) based on poly(disulfide) conjugated with doxorubicin (DOX) on the polymer side chains that exhibits GSH depletion and cascade DOX activation for drug resistance reversal. The poly(disulfide) backbone with a high disulfide d. depletes intracellular antioxidant GSH via the disulfide-thiol exchange reaction to disrupt intracellular redox homeostasis in cells. Simultaneously, DOX can be activated through a cascade reaction, and degradation of the poly(disulfide) backbone further facilitates its drug release. Therefore, poly(disulfide) can be used as a GSH scavenger to reverse MDR as well as a prodrug backbone to target high intracellular GSH levels in cancer cells, providing a general strategy for drug resistance reversal.

Biomaterials published new progress about Antitumor agent resistance. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, HPLC of Formula: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem