Category: 215364-85-5

Related Products of 215364-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 215364-85-5, name is 3-Bromo-2-chloropyridin-4-amine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 3-bromo-2-chloropyridin-4-amine (5.00 g, 24.10 mmol) in concentrated H2S04 (36 mL) at 5 C was added KNO3 (4.87 g, 48.20 mmol). The resultant solution was allowed to warm to room temperature and stir for overnight. The reaction mixture was poured onto ice chips (400 mL) giving a pale yellow precipitate. The precipitate was collected by filtration and washed with water then dried under reduced pressure yield: (5.20 g, 85%). MS [M+H]+= 251.9.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 215364-85-5, 3-Bromo-2-chloropyridin-4-amine.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; REJ, Rohan; (76 pag.)WO2019/222069; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 215364-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 215364-85-5, name is 3-Bromo-2-chloropyridin-4-amine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A 2 L 3 neck RBF was charged with 3-bromo-2-chloro-4-amino-pyridine (50.0 g, 241 mmol) in concentrated H2SO4 (36 mL) at 0 C. open to air. KNO3 (48.7 g, 482 mmol) was then added. The solution was allowed to first warm to room temperature (rt) for 1 h and then was heated to 90 C. for 3 h. The reaction mixture was cooled to rt and was poured into ice water. The obtained solids were filtered and washed with water. After drying under vacuum overnight 3-bromo-2-chloro-5-nitropyridin-4-amine was obtained as an orange-yellow solid (49 g, 81%). This was used directly without further purification.

According to the analysis of related databases, 215364-85-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Universal Display Corporation; Layek, Suman; Ji, Zhiqiang; Dyatkin, Alexey Borisovich; Boudreault, Pierre-Luc T.; Tsai, Jui-Yi; (251 pag.)US2019/393431; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem