Category: 21901-29-1

Kress, Thomas J.; Moore, Larry L.; Costantino, Silvio M. published the artcile< Selective chlorinations in sulfuric acid. Synthesis of some 2-amino-5-chloro-, 2-amino-3-chloro-, and 2-amino-3,5-dichloropyridines>, Safety of 2-Amino-3-nitro-6-picoline, the main research area is pyridine amino chlorination; chlorination aminopyridine sulfuric acid.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. 2-Aminopyridine and a number of Me substituted 2-aminopyridines underwent selective chlorination. The chlorination of 2-aminopyridine at various H2SO4 concentrations and the distribution of chlorinated products was studied in detail. With increasing acidity dichlorination decreases, and in 72% H2SO4 only traces of dichlorination occur. The selectivity of the chlorination reaction is ascribed to differences in the rate of chlorination of protonated vs nonprotonated substrates.

Journal of Organic Chemistry published new progress about Chlorination. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Safety of 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Abou-Elkhair, Reham A. I.; Hassan, Abdalla E. A.; Boykin, David W.; Wilson, W. David published the artcile< Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation>, Safety of 2-Amino-3-nitro-6-picoline, the main research area is lithium hexamethyldisilazane transiently protected azabenzimidazole nitrile; DMSO imidazole ring formation; amidine preparation.

Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58-88% yields. This strategy offers a much better choice to prepare BI/azaBI amidines than the lengthy, low-yielding Pinner reaction. Synthesis of aza/benzimidazole rings from aromatic diamines and aldehydes was affected in DMSO in 10-15 min, while known procedures require long time and purification These methods are important for the BI/azaBI-based drug industry and for developing specific DNA binders for expanded therapeutic applications.

Organic Letters published new progress about Amidines Role: SPN (Synthetic Preparation), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Safety of 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wandas, M.; Lorenc, J.; Kucharska, E.; Maczka, M.; Hanuza, J. published the artcile< Molecular structure and vibrational spectra of 3 (or 4 or 6)-methyl-5-nitro-2-pyridinethiones: FT-IR, FT-Raman and DFT quantum chemical calculations>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is structure vibrational spectra methylnitropyridinethione FT IR Raman DFT quantum.

IR and Raman spectra (RS) of polycrystalline 3-(or 4 or 6)-methyl-5-nitro-2-pyridinethione were measured and analyzed by d. functional theory (DFT) quantum chem. calculations The B3LYP/6-311G(2d,2p) approach was applied for both the thiol and thione tautomers due to the possibility of the formation of these two thiole forms. Mol. structures of these compounds were optimized starting from different mol. geometries of the thiol group and thione group. Two conformations of the 2-mercaptopyridine, trans and cis, were taken into account. The studied compounds appear in the solid state in the thione form. The effect of the hydrogen-bond formation in the studied compounds was considered.

Journal of Raman Spectroscopy published new progress about Conformation. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ritter, Helmut; Kaiser, M. published the artcile< Proton NMR spectra of nitrated aminopyridines>, Related Products of 21901-29-1, the main research area is NMR nitrated aminopyridine hydrogen bond; pyridine aminonitro NMR; steric hindrance hydrogen bond aminonitropyridine.

The 1H NMR spectra of 26 nitrated aminopyridines were measured and interpreted. Chem. shift assignments were based on existing chem. shift rules for substituted pyridines and spectral comparison with compounds of similar structure. Some o-aminonitropyridines were found to give a splitting of the amino signals due to intermol. hydrogen bonding; steric hindrance is shown to influence this bonding.

Magnetic Resonance in Chemistry published new progress about Intramolecular hydrogen bond. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Related Products of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E. published the artcile< Substituent effects on the isomer ratios in the rearrangement of some 2- and 4-nitraminopyridines>, SDS of cas: 21901-29-1, the main research area is substituent effect rearrangement nitraminopyridine.

The preparation and rearrangement in 92% H2SO4 of I-III (R = H, Me, MeO, Br, Cl, CO2H) were investigated. The product isomer ratios can be explained by differential electronic stabilization of the appropriate σ complexes for aromatic nitration and steric effects seem relatively unimportant. Deuteration [3-D in I, R = Me] had no effect on the product distribution.

Australian Journal of Chemistry published new progress about Rearrangement. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, SDS of cas: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; Lotti, Victor J.; Faust, Kristie A.; Schorn, Terry W.; Chen, Tsing Bau published the artcile< Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists>, Name: 2-Amino-3-nitro-6-picoline, the main research area is Angiotensin II antagonist tetrazolylbiphenylylimidazopyridine; imidazopyridine tetrazolylbiphenylyl Angiotensin II antagonist; structure activity antihypertensive tetrazolylbiphenylylimidazopyridine.

Several title Angiotensin II (AII) antagonists I (R = Et, Pr, Bu, R1 = R2 = H, Me; R1 = Me, R2 = H; R1 = H, R2 = Me) were prepared Substituents at the 2, 5, and 7-positions of the imidazopyridine have a profound effect on the in vitro binding affinity to AII receptors (rabbit aorta membrane preparation) and on the inhibition of the AII-induced pressor responses in conscious rats. The most active compound, I (R = Et, R1 = R2 = Me) is extremely potent in vitro (IC50 = 0.3 nM, rabbit aorta), and in vivo (ED50 = 0.048 mg/Kg i.v. and 0.026 mg/Kg p.o., conscious rat). This compound is a specific AT1 antagonist, and substantially lowers the blood pressure of high renin hypertensive rats upon oral dosing (0.1 and 0.3 mg/Kg) with a duration of action exceeding 24 h.

Journal of Medicinal Chemistry published new progress about Antihypertensives. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Xinfeng; Liu, Huanhuan; Xie, Caixia; Zhou, Feiyu; Ma, Chen published the artcile< Terminal methyl as a one-carbon synthon: Synthesis of quinoxaline derivatives via radical-type transformation>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is pyrroloquinoxaline preparation; pyrrolylaniline carbon source carbon hydrogen activation oxidative cyclization iron; indoloquinoxaline preparation; indolylaniline carbon source carbon hydrogen activation oxidative cyclization iron.

An iron-promoted method for the construction of pyrrolo[1,2-a]quinoxaline derivatives I [R1 = H, 7-Me, 7-Br, 8-Cl, etc., R2 = H, Me, X, Y = CH, N] and indolo[1,2-a]quinaxaline derivatives II [R3 = H, 3-F, 2-OMe, etc., R4 = H, Me] was developed via sp3 C-H activation and oxidative cyclization of pyrrolyl-anilines/indolyl-anilines and various carbon sources. This method has many advantages including the availability of raw materials, simple operation, reaction efficiency, universal solvent applicability and wide substrate scope.

New Journal of Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kulkarni, Santosh S.; Newman, Amy Hauck published the artcile< Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is quinoline benzothiazole preparation glutamate receptor antagonist SAR; pyridothiazole imidazopyridine preparation glutamate receptor antagonist SAR.

Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5. Compound I showed antagonist activity (IC50 = 0.26 μM) in the functional assay measuring hydrolysis of phosphoinositide and may provide a new lead for further SAR investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about Metabotropic glutamate receptors, group I, mGluR5 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pegu, David published the artcile< Analysis of molecular structure, vibrational spectra and electronic properties of 2-amino-3-nitro-6-picoline by density functional methods>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is amino nitropicoline mol structure vibrational spectrum electronic property.

In the present study the geometrical parameters and vibrational spectroscopic properties of the compound 2-amino-3-nitro-6-picoline (2A3N6P) have been calculated by using Harteree-Fock and D. functional method (B3LYP) with 6-311++G(d,p) basis set. The calculated optimized structural parameters and the scaled frequencies are investigated and compared with earlier reported data. The complete vibrational assignment and anal. of the fundamental modes of the mol. were carried out. In addition, mol. electrostatic potential and total electron d. has been analyzed to investigate size, shape, charge d. distribution and site on chem. reactivity of the mol. Finally the Mullikan at. charges of the compound have been studied.

Pharma Chemica published new progress about Atomic charge. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pegu, David; Singh, Ngangbam Bedamani published the artcile< Quantum chemical calculations of molecular structure, electronic, thermodynamic and non-linear optical properties of 2-amino-3-nitro-6-methyl pyridine>, Name: 2-Amino-3-nitro-6-picoline, the main research area is amino nitro methyl pyridine mol structure hyperpolarizability.

In the present study, we report a theor. study on mol. structure, electronic and thermodynamical properties of 2-amino-3-nitro-6-Me pyridine (2A3N6MP) by using ab initio Hartree Fock (HF) and d. functional theory (DFT) methods employing B3LYP exchange correlation with 6-311++G(d,p) basis set. The ground state mol. geometrical parameters, have been calculated and compared with available reported values. The calculated HOMO and LUMO energy shows that charge transfer takes place within the mol. and the mol. is chem. soft mol. The dipole moment, linear polarizability and first hyperpolarizability values were also computed. Finally the temperature dependence thermodn. properties were also determined and interpreted.

International Journal of Advanced Research published new progress about Dipole moment. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem