Category: 21901-29-1

Ohmori, Junya; Kubota, Hirokazu; Shimizu-Sasamata, Masao; Okada, Masamichi; Sakamoto, Shuichi published the artcile< Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonists: Synthesis and Structure-Activity Relationships of 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and Related Compounds>, Name: 2-Amino-3-nitro-6-picoline, the main research area is azaquinoxalinedione AMPA receptor antagonist structure activity; imidazolyl pyridopyrazinedione preparation AMPA receptor antagonist.

The authors have synthesized and evaluated azaquinoxalinediones for their activity in inhibiting [3H]AMPA binding from rat whole brain. It was found that the azaquinoxalinedione nucleus functions as a bioisostere for quinoxalinedione in AMPA receptor binding. The detailed structure-activity relationships of 6- and/or 7-substituted 2,3(1H,4H)-pyrido[2,3-b]pyrazinedione derivatives showed some differences in comparison with those of the corresponding substituted quinoxalinediones, including 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (I) (YM90K). X-ray study showed that conformation of the 7-nitro group of I·HCl was nearly coplanar with the quinoxaline ring, whereas the 6-imidazol-1-yl group was rotated with respect to the aromatic ring. Binding studies indicated that the bulkiness of the 6-substituent on the pyridopyrazinediones may be responsible for the selectivity against the glycine site on the NMDA receptor. Among the azaquinoxalinediones tested, 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione (II) exhibited a combination of the best affinity to the AMPA receptor with a Ki value of 0.14 μM and selectivity against the glycine site (no affinity at 10 μM). In vivo, II also protected against sound-induced seizures in DBA/2 mice (min. ED, 10 mg/kg i.p.).

Journal of Medicinal Chemistry published new progress about Anticonvulsants. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Talik, Tadeusz; Talik, Zofia published the artcile< 2-Fluoronitro-derivatives of pyridine and picolines>, HPLC of Formula: 21901-29-1, the main research area is pyridine fluoro nitro; picoline fluoro nitro; diazotization aminopyridine.

6-Fluoro derivatives from 4-nitro- and 3,5- and 3,4-dinitropyridine, 3- and 5-nitro- and 3,5-dinitro-4-picoline, 3- and 5-nitro- and 3,5-dinitro-2-picoline, and 5-nitro-3-picoline as well as 2-fluoro-5-nitro-3-picoline were prepared in 52.5-85% yields by diazotization of the corresponding amino derivatives in 65% HF.

Roczniki Chemii published new progress about 21901-29-1. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chand, Pooran; Kotian, Pravin L.; Morris, Philip E.; Bantia, Shanta; Walsh, David A.; Babu, Yarlagadda S. published the artcile< Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase>, Synthetic Route of 21901-29-1, the main research area is benzoate pyridine derivative preparation influenza neuraminidase inhibitor SAR.

Based upon the activity and X-ray crystallog. studies of tri-substituted benzene derivatives containing carboxylic acid, acetamido and guanidine groups, we investigated the effect of the fourth substituent to fulfill the fourth pocket of neuraminidase enzyme. The groups selected as fourth substituents were hydroxymethyl, hydroxyethyl, oxime and amino. These tetra-substituted benzene derivatives were synthesized and evaluated for neuraminidase inhibitory activity. All these compounds were found to have poorer IC50 values than the tri-substituted compounds Further, benzene ring was replaced by pyridine ring and di, tri and tetra-substituted pyridine derivatives were synthesized. The activity of the pyridine derivatives was comparable to benzene derivatives The fourth substituent seems to disturb the binding of the other three substituents, so the activity is reduced as compared to tri-substituted benzene and pyridine derivatives

Bioorganic & Medicinal Chemistry published new progress about Influenza virus. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Shichen; Feng, Lei; Ma, Chen published the artcile< Simple and green synthesis of benzimidazoles and pyrrolo[1,2-a]quinoxalines via Mamedov heterocycle rearrangement>, HPLC of Formula: 21901-29-1, the main research area is benzimidazole pyrroloquinoxaline preparation green chem Mamedov heterocycle rearrangement.

A method for the synthesis of coupling compounds of benzimidazoles and pyrrolo[1,2-a]quinoxalines via Mamedov Heterocycle Rearrangement is reported here. This method was conducted at room temperature and only solvent (HOAc) was required. A series of 4-(1H-benzo[d]imidazol-2-yl)pyrrolo[1,2-a]quinoxaline derivatives were obtained in moderate to good yields.

New Journal of Chemistry published new progress about Benzimidazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem