Category: 21901-40-6

Adding a certain compound to certain chemical reactions, such as: 21901-40-6, 4-Methyl-5-nitropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Methyl-5-nitropyridin-2-amine, blongs to pyridine-derivatives compound. name: 4-Methyl-5-nitropyridin-2-amine

mixture of 2-bromo-5-mtro-4-pyridine (100 mg, 0.461 raraol), copper (I) iodide (73.1 mg, 0.384 mmol) and methyl 2,2-difluoro-2-(fluorosulfonyl)acetate (177 mg, 117 muL, 0.922 mmol) in dry DMF (1 mL) was heated under N2 at 120 0C overnight. The reaction mixture was cooled to room temperature and diluted with saturated NH4Cl (3.6 mL) and NH4OH (0.4 mL). The mixture was stirred until homogenous (a little water was added). The mixture was extracted with EtOAc (3 x 20 mL). The combined extracts were washed with brine (10 mL), dried (Na2SO4) and concentrated in vacuo to give the crude product. This was purified by flash chromatography (Si, 12 x 160 mm, 0-20% EtOAc in hexanes gradient) to afford 4- methyl-5-nitro-2-(trifluoromethyl)pyridine. LCMS calc. = 207.1; found = 207.1 (M+l)+. 1H NMR (500 MHz5 CDCl3): delta 9.17 (s, 1 H); 7.70 (s, 1 H); 2.72 (s, 3 H).

The synthetic route of 21901-40-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2007/81569; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 21901-40-6, 4-Methyl-5-nitropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Methyl-5-nitropyridin-2-amine, blongs to pyridine-derivatives compound. name: 4-Methyl-5-nitropyridin-2-amine

mixture of 2-bromo-5-mtro-4-pyridine (100 mg, 0.461 raraol), copper (I) iodide (73.1 mg, 0.384 mmol) and methyl 2,2-difluoro-2-(fluorosulfonyl)acetate (177 mg, 117 muL, 0.922 mmol) in dry DMF (1 mL) was heated under N2 at 120 0C overnight. The reaction mixture was cooled to room temperature and diluted with saturated NH4Cl (3.6 mL) and NH4OH (0.4 mL). The mixture was stirred until homogenous (a little water was added). The mixture was extracted with EtOAc (3 x 20 mL). The combined extracts were washed with brine (10 mL), dried (Na2SO4) and concentrated in vacuo to give the crude product. This was purified by flash chromatography (Si, 12 x 160 mm, 0-20% EtOAc in hexanes gradient) to afford 4- methyl-5-nitro-2-(trifluoromethyl)pyridine. LCMS calc. = 207.1; found = 207.1 (M+l)+. 1H NMR (500 MHz5 CDCl3): delta 9.17 (s, 1 H); 7.70 (s, 1 H); 2.72 (s, 3 H).

The synthetic route of 21901-40-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2007/81569; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem