2215-33-0 | Pyridine-derivatives

Surov, O. V.’s team published research in Physical Chemistry: An Indian Journal in 12 | CAS: 2215-33-0

Physical Chemistry: An Indian Journal published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C5H10Cl3O3P, Quality Control of 2215-33-0.

Surov, O. V. published the artcileEnthalpies of Fusion, sublimation and vaporization of some hydrazones, Quality Control of 2215-33-0, the publication is Physical Chemistry: An Indian Journal (2017), 12(1), 1-15, database is CAplus.

Enthalpies of melting, sublimation and vaporization were determined for some hydrazones. The validity of thermogravimetric procedure for measuring enthalpy of vaporization of the compounds under investigation was demonstrated. Exploring packing modes and intermol. interactions in mol. crystals of the hydrazones using Hirshfeld surfaces was carried out.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vecchio-Sadus, Angelica M.’s team published research in Transition Metal Chemistry (London) in 20 | CAS: 2215-33-0

Transition Metal Chemistry (London) published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C4Br2N2O4S, Category: pyridine-derivatives.

Vecchio-Sadus, Angelica M. published the artcileElectrosynthesis and magnetic behavior of neutral cobalt(II) complexes of pyridine-2-carbaldehyde pyridin-2′-ylhydrazone (papyH) and its analogs, Category: pyridine-derivatives, the publication is Transition Metal Chemistry (London) (1995), 20(1), 38-45, database is CAplus.

Neutral cobalt(II) complexes with the tridentate N-heterocyclic ligand pyridine-2-carbaldehyde pyridin-2′-ylhydrazone (papyH) and its analogs were prepared by the electrochem. oxidation of cobalt in an acetone solution of the hydrazone. [Co(papy)₂] were obtained as red-green dichroic microcrystals due to the extended π-conjugation system in the anionic ligand. The magnetic moments of the octahedral cobalt(II) chelates decrease continuously from μ_eff = 1.81-4.63 μB at room temperature to 1.7-4.08 μB at ∼90 K. The changes in magnetic moment were accounted for by a ⁴T₁ ↔ ²E spin crossover system.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vecchio-Sadus, Angelica M.’s team published research in Transition Metal Chemistry (London) in 20 | CAS: 2215-33-0

Vecchio-Sadus, Angelica M. published the artcileElectrochemical synthesis of neutral transition metal(II) (Fe, Co, Ni, Cu, Zn) complexes of pyridine-2-carbaldehyde pyridine-2′-ylhydrazone and several analogs, SDS of cas: 2215-33-0, the publication is Transition Metal Chemistry (London) (1995), 20(3), 256-61, database is CAplus.

Neutral transition metal(II) complexes of pyridine-2-carbaldehyde pyridine-2′-ylhydrazone (papyH) and several analogs were prepared by electrochem. synthesis. [M(papy)₂] (M = Fe, Co, Ni, Cu or Zn) were obtained mostly as red-green dichroic substances as a result of the extended π-conjugation system in the anionic hydrazone. Vibrational and electronic spectra confirm the presence of the anionic hydrazone and its tridentate coordination to the metal center.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Anderegg, Giorgio’s team published research in Helvetica Chimica Acta in 54 | CAS: 2215-33-0

Helvetica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Anderegg, Giorgio published the artcilePyridine derivatives as complexing agents. IX. Stability constants of complexes with 2-aminomethylpyridine, 6-methyl-2-aminomethylpyridine, 2-pyridylhydrazine, 2,2′-dipyridylamine, and 1-(α-pyridylmethylene)-2-(α’-pyridyl)hydrazine, COA of Formula: C11H10N4, the publication is Helvetica Chimica Acta (1971), 54(2), 509-12, database is CAplus.

The stability constants for the Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Hg(II), Cd(II), and Ag(I) complexes of 2-aminomethylpyridine, 6-methyl-2-aminomethylpyridine, 2-pyridylhydrazine, 2,2′-dipyridylamine, 1-(2-pyridylmethylene)-2-(2′-pyridyl)hydrazine are reported. In all cases logK1 > logK2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chiswell, B.’s team published research in Australian Journal of Chemistry in 21 | CAS: 2215-33-0

Australian Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Related Products of pyridine-derivatives.

Chiswell, B. published the artcilePlatinum complexes of some deprotonatable tridentate ligands, Related Products of pyridine-derivatives, the publication is Australian Journal of Chemistry (1968), 21(8), 1997-2001, database is CAplus.

Pt(II) and Pt(IV) complexes of 1,3-bis(2-pyridyl)-1,2-diazaprop-2-ene and ligands of similar structure, but with Me “blocking groups” adjacent to the pyridine N atoms, were studied. In neutral solution, these ligands lose a proton upon interaction with either Pt(II) or Pt(IV) salts to yield highly colored complexes soluble in organic solvents. Protonated compounds of both oxidation states can be obtained, but such compounds are unstable in neutral solution and readily yield deprotonated complexes.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mihkelson, A. E.’s team published research in Journal of Inorganic and Nuclear Chemistry in 43 | CAS: 2215-33-0

Journal of Inorganic and Nuclear Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application In Synthesis of 2215-33-0.

Mihkelson, A. E. published the artcileReactions of palladium(II) with a series of potentially tridentate nitrogen ligands. II. Solution studies, Application In Synthesis of 2215-33-0, the publication is Journal of Inorganic and Nuclear Chemistry (1981), 43(1), 127-36, database is CAplus.

Potentiometric and conductometric titrations of Pd²⁺ and pyridine-2-carboxaldehyde 2′-pyridylhydrazone (HL) in aqueous solution showed that only 1 mol of L coordinates with each Pd in solution There was no evidence for PdL₂ formation in aqueous solution Equilibrium constants were estimated for a model system using Job’s method of continuous variations. Proton NMR of PdL₂ and PdL¹OAc (HL¹ = 6-methylpyridine-2-carboxaldehyde 2′-pyridylhydrazone) showed that the ligand undergoes isomerization about the imine bond.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dong, Jie’s team published research in Nature Chemistry in 13 | CAS: 2215-33-0

Nature Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Dong, Jie published the artcileManganese-catalysed divergent silylation of alkenes, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Nature Chemistry (2021), 13(2), 182-190, database is CAplus and MEDLINE.

Transition-metal-catalyzed, redox-neutral dehydrosilylation of alkenes is a long-standing challenge in organic synthesis, with current methods suffering from low selectivity and narrow scope. The authors report a general and simple method for the Mn-catalyzed dehydrosilylation and hydrosilylation of alkenes, with Mn₂(CO)₁₀ as a catalyst precursor, by using a ligand-tuned metalloradical reactivity strategy. This enables versatility and controllable selectivity with a 1:1 ratio of alkenes and silanes, and the synthetic robustness and practicality of this method are demonstrated using complex alkenes and light olefins. The selectivity of the reaction was studied using d. functional theory calculations, showing the use of an ⁱPrPNP ligand to favor dehydrosilylation, while a JackiePhos ligand favors hydrosilylation. The reaction is redox-neutral and atom-economical, exhibits a broad substrate scope and excellent functional group tolerance, and is suitable for various synthetic applications on a gram scale. [graphic not available: see fulltext].

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fu, Shibo’s team published research in PLoS One in 7 | CAS: 2215-33-0

PLoS One published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Synthetic Route of 2215-33-0.

Fu, Shibo published the artcileγ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers, Synthetic Route of 2215-33-0, the publication is PLoS One (2012), 7(6), e38465, database is CAplus and MEDLINE.

Background: Persistence of γ-H2AX after ionizing radiation (IR) or drug therapy is a robust reporter of unrepaired DNA double strand breaks in treated cells. Methods: DU-145 prostate cancer cells were treated with a chem. library ±IR and assayed for persistence of γ-H2AX using an automated 96-well immunocytochem. assay at 4 h after treatment. Hits that resulted in persistence of γ-H2AX foci were tested for effects on cell survival. The mol. targets of hits were validated by mol., genetic and biochem. assays and in vivo activity was tested in a validated Drosophila cancer model. Results: We identified 2 compounds, MS0019266 and MS0017509, which markedly increased persistence of γ-H2AX, apoptosis and radiosensitization in DU-145 cells. Chem. evaluation demonstrated that both compounds exhibited structurally similar and biochem. assays confirmed that these compounds inhibit ribonucleotide reductase. DNA microarray anal. and immunoblotting demonstrates that MS0019266 significantly decreased polo-like kinase 1 gene and protein expression. MS0019266 demonstrated in vivo antitumor activity without significant whole organism toxicity. Conclusions: MS0019266 and MS0017509 are promising compounds that may be candidates for further development as radiosensitizing compounds as inhibitors of ribonucleotide reductase.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Surov, O. V.’s team published research in Physical Chemistry: An Indian Journal in 12 | CAS: 2215-33-0

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vecchio-Sadus, Angelica M.’s team published research in Transition Metal Chemistry (London) in 20 | CAS: 2215-33-0

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem