Category: 2215-33-0

Crichton, Robert R. published the artcileIron mobilization from ferritin by chelating agents, HPLC of Formula: 2215-33-0, the publication is Journal of Inorganic Biochemistry (1980), 13(4), 305-16, database is CAplus and MEDLINE.

The release of Fe from horse spleen ferritin (I) by the chelating agents, deferrioxamine B (II), rhodotorulic acid (III), 2,3-dihydroxybenzoate (IV), 2,2′-bipyridyl (V), and pyridine-2-aldehyde 2-pyridylhydrazone (VI), was studied in vitro. I prepared by classical procedures involving thermal denaturation released its Fe less effectively than I isolated by a modified procedure that avoided this step. II and III were the most effective in releasing Fe from both preparations of I. When FMN was added, Fe release by II, III, and IV was effectively blocked, whereas both V and VI showed a marked simulation. A substantial increase in Fe release was also observed for V and VI with ascorbate; a less important increase was noted for III. EDTA exerted a marked inhibition of Fe release from I with III, IV, V, and VI. The effects of citrate and oxalate on Fe release by the chelators was small. The effect of the concentration of flavin on Fe release from I by II and V was studied. II was unable to mobilize Fe(II) from I following reduction by reduced FMN, whereas V could rapidly complex Fe(II). The results are discussed in the context of current concepts of storage Fe mobilization in the treatment of Fe overload.

Journal of Inorganic Biochemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, HPLC of Formula: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Crichton, Robert R. published the artcileFerritin iron mobilization by chelating agents, Quality Control of 2215-33-0, the publication is FEBS Letters (1980), 110(2), 271-4, database is CAplus and MEDLINE.

The release of ferritin Fe in vitro by 5 Fe chelators was examined Deferrioxamine B (I) and rhodotorulic acid (II) released the greatest amounts of Fe from ferritin; over 24 h incubation at 37°, I and II released 225 and 250 g-atoms Fe/ferritin mol., resp. Of the other chelators, only pyridine-2-aldehyde-2-pyridylhydrazone (III) gave a reasonable release of 85 g-atoms Fe/ferritin mol. in 24 h. The effects of ascorbate, EDTA, and FMN on Fe release were also studied. FMN (1 mM) almost completely inhibited Fe release by I and II, 2 Fe-chelators currently employed in the treatment of Fe overload; the possible in vivo inhibition of these compounds by endogenous flavins was discussed. In contrast, Fe mobilization by III and bipyridyl was substantially enhanced by FMN.

FEBS Letters published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bell, Colin Frank published the artcileNephelometric determination of silver and mercury with bis(I,3-di-(2′-pyridyl)-I,2-diaza-2-propenato) cobalt(III) perchlorate, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1970), 52(2), 313-21, database is CAplus.

Procedures are described for the nephelometric determination of Ag and Hg, based on adduct-formation with the Co(III) complex of 1,3-di(2-pyridyl)-1,2-diaza-2-propene (PAPHY). The procedures are rapid, sensitive, and reproducible and compare favorably with other nephelometric methods for these metals. The nature of the adducts is discussed.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dumitru, Florina published the artcileHomo- and heteroduplex complexes containing terpyridine-type ligands and Zn²⁺, Synthetic Route of 2215-33-0, the publication is European Journal of Inorganic Chemistry (2005), 4255-4262, database is CAplus.

We describe a study of the equilibrium binding of Zn²⁺ to binary mixtures of tridentate ligands terpyridine (1), 2,5-(CHNC₆H₅)₂pyridine (2) and (2-pyridyl)NHNCH(2-pyridyl) (3) which leads to the formation of a dynamic mixture of homo ([Zn(1)₂](CF₃SO₃)₂ 4, [Zn(2)₂](CF₃SO₃)₂ 5, [Zn(3)₂](CF₃SO₃)₂ 6) and hetero ([Zn(1)(3)](CF₃SO₃)₂ 7, [Zn(1)(2)](CF₃SO₃)₂ 8, [Zn(2)(3)](CF₃SO₃)₂ 9) coordination compounds We report the crystal structures of five such complexes (4, 5, 7–9) which assemble into complementary duplex compounds that further self-organize into double helical- or lamellar-type architectures in the solid state. The ligand exchange between homo-duplex complexes in solution leads to the preferential formation of the heteroduplex complexes. As might be expected these processes display a statistical distribution of homo-duplex:heteroduplex:homo-duplex complexes of 1:2:1 for the mixtures resulting from 4:6 and 5:6 ligands. However, complex 8 is preferred in a 4:5 mixture which presents a composition of 1:4:1 (amplification factor of about 33%). The X-ray structural determinations of selected single crystals resulting from the stoichiometric mixtures of homo-duplex complexes show unique heteroduplex superstructures 7–9 in the solid state. The present results present the solid-state structures of homo- and hetero-complexes resulting from terpyridine-type ligands 1–3 and Zn²⁺ metal ions. The heteroduplex Zn²⁺ complexes 7–9 are quant. crystallized in the solid state by statistical (7, 9) and structural (8) driven selection in solution from a binary mixture of the terpyridine-type complexes and then trapped by crystallization in the solid state.

European Journal of Inorganic Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Synthetic Route of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ishii, Hajime published the artcileEquilibria and kinetics of the extraction of nickel with 2-pyridinecarbaldehyde 2-(5-substituted)pyridylhydrazones, Formula: C11H10N4, the publication is Analytical Sciences (1988), 4(1), 73-6, database is CAplus.

The equilibrium and kinetics of the extraction of Ni with benzene solutions of 2-pyridinecarbaldehyde 2-(5-substituted)pyridylhydrazones were studied at 25 ± 0.1° and an ionic strength of 0.2. The extracted species was found too be NiL₂ for each hydrazone, where L denotes the undissociable part of the hydrazone. Partition constants of the hydrazones and extraction constants of their Ni complexes between an aqueous and a benzene phase were determined The rate of extraction was best described by a two-term expression, both terms being 1st order in Ni ion and HL concentrations The first term has zero dependence on H⁺ concentration, whereas the 2nd is inversely first order with respect to H⁺ concentration These results support the hypothesis that the rate-determining steps involve 2 concurrent reactions of Ni with neutral and anionic forms of the hydrazones. Kinetic data and activation parameters for the first reaction were determined, but those for the second one involving the anion could not be obtained.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileExtraction equilibria of nickel(II) with several heterocyclic substituted hydrazones, Quality Control of 2215-33-0, the publication is Analytical Sciences (1993), 9(6), 835-41, database is CAplus.

The extraction of nickel(II) with seven N,N,N-tridentate heterocyclic hydrazones, a neutral form of which is abbreviated as HL, using chloroform or benzene as an extraction solvent has been studied, the extraction equilibrium being analyzed on the basis of the data for the proton dissociation of H₃L²⁺, the formation of Ni(HL)²⁺ and Ni(HL)₂²⁺ complexes and the proton dissociation of Ni(HL)₂²⁺ complexes in aqueous solution Nickel(II) is extracted as NiL₂ although it forms such complexing ions an Ni(HL)²⁺ or Ni(HL)₂²⁺ in the aqueous phase. The distribution constants of HL and NiL₂ (the abbreviations of which are K_d and K_dm, resp.) have been determined under the same condition as in aqueous solution The logarithmic plots of Kdm vs. K_d displayed two straight lines with slopes of 1.9; one is for hydrazones bearing one pyridyl or one quinolyl ring in the aldehyde moiety and the other for hydrazones bearing another pyridyl ring introduced to the aldehyde moiety. This is attributed to an intramol. hydrogen bond between the imino hydrogen and the nitrogen of pyridine of the latter hydrazones.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C13H16BFO4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileKinetic study of solvent extraction of nickel(II) from aqueous solution by some heterocyclic substituted-hydrazones, Application In Synthesis of 2215-33-0, the publication is Analytical Sciences (1991), 7(Suppl.), 21-4, database is CAplus.

Solvent extraction of nickel(II) complexes with five heterocyclic hydrazones (containing pyridine- or/ and quinoline-nitrogen atoms as the coordinating sites) into chloroform or benzene was studied kinetically at 25°C and μ = 0.1 by means of a spectrophotometric method. The kinetics of extraction of nickel(II) ion is first order in each of the aqueous nickel(II) concentration and the hydrazone concentration in the organic phase. The observed second-order rate constant, k_obs, -pH profiles suggest three rate-determining steps to be considered in the aqueous phase: Ni²⁺ + H₂L⁺ â†? Ni²⁺ + HL â†?and Ni(OH)⁺ + HL â†? The rate constant for the formation of 1:1 complexes with 2-pyridylmethanone 2-pyridylhydrazone (PAPH) was consistent with those for bipyridine and terpyridine. Replacement of pyridyl group by quinolyl group affects the distribution constant (K_d) of the ligand between the two phases rather than the rate constants The influence of the structure of ligands on the rate constants is also discussed.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C18H34N4O5S, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bryson, D. J. published the artcileFar infrared spectra of five-coordinate complexes, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Inorganic and Nuclear Chemistry Letters (1969), 5(5), 347-8, database is CAplus.

Examination of the spectra of complexes formed by the ligand 2-pyridine-carboxaldehyde 2′-pyridylhydrazone (paphy) in the region 400-150 cm.-1 indicates that a distinction may probably be made between 4, 5, and 6 coordination because of differences in frequencies of the peaks assignable to metal-halogen vibrations. The metal-halogen frequencies are presented for the 5-coordinate complexes: M(paphy)X2,M = β-Co, Mn, Zn, X = Cl, Br; the octahedral complexes: α-Co(paphy)Cl2, Ni(paphy)Cl2, and Ni-(paphy)Br2; and the tetrahedral pyridine complexes: M(py)2X2, X = Co, Zn, X = Cl, Br.

Inorganic and Nuclear Chemistry Letters published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ishii, Hajime published the artcileSynthesis of sensitive pyridylhydrazone reagents and extraction-spectrophotometric determination of trace nickel with 2-pyridinecarboxaldehyde 2-(5-nitro)pyridylhydrazone, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytical Sciences (1987), 3(4), 347-52, database is CAplus.

Three new hydrazones, in which the hydrogen at the 5-position of the pyridine ring in the hydrazine moiety of 2-pyridinecarboxaldehyde 2-pyridylhydrazone was substituted by a Me, chloro, or nitro group, have been synthesized and their chromogenic properties, reactivities with metal ions, and extractabilities of the metal complexes were studied. The acid dissociation constants (K_a) of the synthesized hydrazones were determined spectrophotometrically. These values obeyed Hammett’s law, the inductive effect of the substituents being found to reflect the pK_a values. Of the synthesized hydrazones, 2-pyridinecarboxaldehyde 2-(5-nitro)pyridylhydrazone (PANPH), in which an electron-withdrawing nitro group was introduced, was most sensitive for metal ions. Its copper and nickel complexes showed molar absorptivities of the order of 10⁵. A highly sensitive and selective extraction-spectrophotometric method for the determination of nickel with PANPH is proposed and has been successfully applied to the determination of nickel in steel samples. The method has been further sensitized by employing analog derivative spectrophotometry.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileComplexation behavior of heterocyclic hydrazones. II. Effects of steric factors on formation constants for nickel(II) complexes with heterocyclic hydrazones, Related Products of pyridine-derivatives, the publication is Bulletin of the Chemical Society of Japan (1994), 67(3), 710-19, database is CAplus.

The equilibrium of nickel(II) ion with thirteen nitrogen-heterocyclic hydrazones (neutral form: HL) with and without blocking group(s) have been investigated spectrophotometrically in 28% aqueous dioxane solution at 25°C and an ionic strength of 0.2 (KCl). For a series of 2-pyridinecarbaldehyde 5-substituted-2-pyridylhydrazones, the following linear free energy relationships (LFER) were derived between the overall formation constants, β₁, β₁‘, and β₂, of Ni(HL)²⁺, NiL⁺, and Ni(HL)₂²⁺ complexes, resp., and the dissociation constants, K_a1 and K_a2, of H₃L²⁺ and H₂L⁺, resp.: log β₁ = 0.95 (pK_a1 + pK_a2)/2 + 4.60, 1/2 log β₂ = 0.95 × (pK_a1 + pK_a2)/2 + 4.82, and log β₁‘ = 1.40 (pK_a1 + pK_a2)/2 + 9.73. The steric effects of the 6-Me group in pyridine and the quinolyl ring in place of pyridyl group on the complex formation were evaluated on the basis of LFER. The complex stabilization effect of the pyridyl group substituted for formyl hydrogen was also evaluated for Ni(HL)₂²⁺, Ni(HL)²⁺, and NiL⁺ complexes. These results together with LFER were discussed in conjunction with the thermodn. parameters for the formation of Ni(HL)²⁺ complex and the ligand field parameters, D_q, for Ni(HL)²⁺ and Ni(HL)₂²⁺ complexes.

Bulletin of the Chemical Society of Japan published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C7H8BBrO3, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem