Category: 2215-33-0

Shapiro, Anna published the artcileIn vivo and in vitro activity by diverse chelators against Trypanosoma brucei brucei, Product Details of C11H10N4, the publication is Journal of Protozoology (1982), 29(1), 85-90, database is CAplus and MEDLINE.

A system of prescreens and a screen was developed to select chelators as potential drugs against T. brucei brucei EATRO 110. The chelators tested were nearly all com. available, low mol., and had a moderate to high affinity for Fe(III). Seventy compounds showing heme-sparing or inhibitory activity in a Crithidia fasciculata growth system having excess Fe and minimal hemin were prescreened. Of these, 45 were highly trypanocidal for suspensions of bloodstream T. brucei brucei; criteria of activity here were immobilization, lysis, and loss of infectivity. Eighteen of the chelators highly active in the suspension prescreen were tried in T. brucei brucei-infected mice. Thirteen of these chelators were curative in mice with 24-h infections, i.e., they allowed survival >30 days beyond the untreated controls, caffeic acid  [331-39-5], neocuproine  [484-11-7], and 2-pyridinecarboxaldehyde-2-pyridylhydrazone  [2215-33-0] cure 5 out of 5 mice after an i.v. dose of 100 mg/kg. salicylaldehyde thiosemicarbazone  [5351-90-6] Cured 5 of 5 mice at an i.p. dose of 500 mg/kg. Lesser activity was shown by several other chelators.

Journal of Protozoology published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C13H18BFO2, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Garcia Sanchez, F. published the artcileCoupled redox and complex formation processes as a kinetic fluorometric method for the determination of cobalt, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Fresenius’ Zeitschrift fuer Analytische Chemie (1983), 315(6), 491-5, database is CAplus.

A sensitive and relatively interference-free method for the kinetic determination of Co is described. The method is based on the slow oxidation of 2-pyridinealdehyde 2-pyridylhydrazone (PAPH) by BrO₃^– to a fluorescent product. Complexation of PAPH with Co causes a decrease in the rate of oxidation, which is related to the concentration of Co and also to the stability constant of the complex. The influence of reaction variables and the effect of foreign ions are discussed. Co 20-150 ng mL^-1 can be determined with a relative standard deviation of 4%. The absorption of the 1:2 Co PAPH complex was measured at 440 nm.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Todeschini, A.R. published the artcile2-Pyridylarylhydrazone derivatives, a new class of platelet aggregation inhibitors, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Brazilian Journal of Medical and Biological Research (1996), 29(3), 389-93, database is CAplus and MEDLINE.

A series of 2-pyridylarylhydrazone derivatives was synthesized and compared with a previously reported pyrazole series, i.e., 4-acylpyrazolylarylhydrazone and 5-pyrazolylarylhydrazone, which present antiplatelet aggregation activity. The structures of these pyridylarylhydrazone derivatives were designed on the basis of the known bioisosteric relation of the heteroaromatic ring. The antiplatelet aggregation activity was measured in vitro on citrated platelet-rich rabbit plasma in which aggregation was induced with 5 μM ADP, 5 μg/mL collagen and 200 μM arachidonic acid. Eighteen compounds belonging to the pyridine series were tested at 1 mM concentration and none inhibited ADP-induced rabbit platelet aggregation. 2-(2-Formylfurane)pyridylhydrazone exhibited a highly potent inhibitory activity on arachidonic acid-induced aggregation, with an IC₅₀ of 0.35 μM. These results suggest that the hydrazone unit and the 2-furyl moiety of the arylhydrazone framework are important pharmacophores for antiplatelet activity.

Brazilian Journal of Medical and Biological Research published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C15H20O6, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hidalgo, M. published the artcileSurface-enhanced resonance Raman spectroscopy of 2-pyridylhydrazone and 1,10-phenanthroline chelate complexes with metal ions on colloidal silver, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1996), 318(2), 229-37, database is CAplus.

Surface-enhanced resonance Raman spectra (SERRS) of the complexes PAPH-Co(II), PAPH-Ni(II), PAPH-Fe(II), and PHEN-Fe(II) (PAPH = 2-pyridine carboxyaldehyde 2-pyridylhydrazone and PHEN = 1,10-phenanthroline) adsorbed on silver colloid have been studied. Differences among SERS spectra of ligands and SERRS spectra of complexes have been investigated. Ultra-sensitive methods for metal determination with limits of detection at the ng mL^-1 level are presented.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Laserna, J. J. published the artcileKinetic determination of cobalt by complexation with pyridine-2-aldehyde 2-pyridylhydrazone and ligand oxidation with bromate, Category: pyridine-derivatives, the publication is Mikrochimica Acta (1985), 2(5-6), 457-67, database is CAplus.

Optimum conditions are outlined for the kinetic determination of Co. The rate of disappearance of pyridine-2-aldehyde 2-pyridylhydrazone (PAPH) in acidic medium is monitored spectrophotometrically at 372 nm. The method is based on the modification of the oxidation rate by complexation of PAPH with Co ions. The detection limit was 0.25 μg/mL. Beer’s law was obeyed for 0.40-1.50 μg/mL.

Mikrochimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Frankish, Neil H. published the artcileThe indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis, Computed Properties of 2215-33-0, the publication is Journal of Pharmacy and Pharmacology (2018), 70(1), 101-110, database is CAplus and MEDLINE.

Objectives : Compounds PH2 and PH5 are distereoisomers of novel indane compounds, synthesized as analogs of secondary metabolites of the fern, Onychium. In this study, we compare their effects on a variety of inflammatory models. Methods : In an effort to extend our knowledge of their anti-inflammatory profile, we have investigated their activity in two models of delayed-type hypersensitivity (DTH); the methylated bovine serum albumin model (mBSA) and the oxazolone contact hypersensitivity (CHS) model, on IL2 release from Jurkat cells and in the dextran sulfate sodium (DSS) murine model of inflammatory bowel disease. Key findings : Both diastereoisomers are equipotent in reducing paw swelling in the mBSA model and in inhibiting interleukin (IL) 2 release from Jurkat cells. They are equally ineffective in the oxazolone contact hypersensitivity model (CHS). Only the diastereoisomer, PH5, protects against DSS-induced colitis and of its two enantiomers, only the S,S-enantiomer, PH22, possesses this activity. PH2 is ineffective in the DSS model. Conclusions : The results suggest that the beneficial effect of PH5, and its enantiomer PH22, in the DSS model is a consequence of an action on a target specific to the colitis model. The implications of such data suggest an unknown target in this disease model that may be exploited to therapeutic advantage.

Journal of Pharmacy and Pharmacology published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Computed Properties of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Radunsky, Christian published the artcileA Family of Hydrazone-Based Nucleosides for Use in Metal-Mediated Base Pairs, COA of Formula: C11H10N4, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2013), 639(8-9), 1621-1627, database is CAplus.

A new family of hydrazone-based nucleosides for use in metal-mediated base pairs was devised. The artificial nucleobases are derivatives of the papy ligand (papy = pyridinecarboxaldehyde-2′-pyridylhydrazone). By replacing the pendant pyridine moiety in papy by furan and thiophene, resp., tridentate nucleosides with N, N, N-, N, N, O- and N, N, S-donor sites were obtained. As only a few transition metal complexes with pendant furan ligands are reported, a model nucleobase (furancarboxaldehyde-2′-pyridylhydrazone) for the N,N,O-donor nucleoside was synthesized. The mol. structures of its Cu²⁺, Ni²⁺, and Co²⁺ complexes are reported. In all complexes, only weak M-O(furan) bonding is observed The Co²⁺ complex displays a pentagonal bipyramidal coordination arrangement. In general, the structures of the metal complexes suggest that the resp. nucleosides can be applied in metal-mediated base pairs.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chowdhury, Santanu published the artcileA new luminescent sulfate bridged dimeric copper(II) complex with DNA binding and SO₂ fixation ability: Synthesis and structure, Computed Properties of 2215-33-0, the publication is Polyhedron (2009), 28(17), 3863-3871, database is CAplus.

New luminescent mononuclear and dinuclear Cu(II) (S = 1/2) complexes [Cu(HL)(H₂O)₂](ClO₄)₂ (1a) and [Cu₂(HL)₂(μ-SO₄)₂]·2H₂O (1b) were synthesized with the acyclic tridentate pyridine-2-carboxaldehyde-2-pyridylhydrazone ligand, HL (1). The mononuclear complex 1a can be converted into the disulfate bridged dimeric Cu(II) complex 1b by passing freshly prepared SO₂ through the basic medium. On excitation at 290 nm, the ligand fluoresces at 364 nm due to an intraligand ¹(π-π^_*) transition. Upon complexation with Cu(II), the emission peak is slightly blue shifted (356 nm, F/F ₀ 0.76 for 1a and 354 nm, F/F ₀ 0.89 for 1b) with a little quenching in the emission intensity. The association constants (K_ass (5.06 ± 0.004) × 10⁴ for 1a and K_ass (5.46 ± 0.006) × 10⁴ for 1b at 298 K) and the thermodn. parameters were determined by UV-visible spectroscopy. The mol. structure of the complex 1b (Cu···Cu 4.456 Å) was determined by single crystal x-ray diffraction studies. The complex 1b exhibits a strong interaction towards DNA as revealed from the K_b (intrinsic binding constant) 6.3 × 10⁴ M^-1 and K_sv (Stern-Volmer quenching constant) 2.93 values.

Polyhedron published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Computed Properties of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileReactions between technetium(VII) and some hydrazones and the spectrofluorometric determination of technetium(VII) with 2,2′-dipyridyl ketone hydrazone, Product Details of C11H10N4, the publication is Analytica Chimica Acta (1984), 71-8, database is CAplus.

The reactions between pertechnetate and 5 hydrazones are described. Of these, the Tc(VII)/2,2′-dipyridyl ketone hydrazone system was found to be most sensitive, and was studied in detail. Spectrofluorometric procedures for the determination of Tc(VII) over the range 0.01-12 mg L^-1 are reported. The reaction proceeds most favorably under acidic conditions (1.4M HCl). For 1 mg L^-1 Tc(VII), 100 mg L^-1 levels of U(VI), Re(VII), Mo(VI), or W(VI) do not interfere when the reaction proceeds at room temperature Sensitivity improves at higher temperatures

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileFluorometric reaction-rate method for determination of mercury with 2,2′-dipyridyl ketone hydrazone, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Microchemical Journal (1985), 32(3), 367-72, database is CAplus.

A simple and sensitive fluorometric reaction-rate method for determination of Hg(II) (0.03-0.3 ppm), based on its catalytic effect on the autoxidation of 2,2′-dipyridyl ketone hydrazone, was developed. The reaction is followed by the measurement of the rate of appearance of the blue fluorescence (λ_ex = 359, λ_em = 430 nm). The exptl. variables and interferences in the determination are also reported.

Microchemical Journal published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem