Category: 2215-33-0

Mohan, M. published the artcileSynthesis, characterization and antitumor properties of some metal(II) complexes of 2-pyridinecarboxaldehyde 2′-pyridylhydrazone and related compounds, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Inorganica Chimica Acta (1988), 151(1), 61-8, database is CAplus.

MLX₂ (M = Mn, Fe, Co, Ni, Cu, Pt, X = Cl; M = Zn, X = OAc; L = 2-pyridinecarboxaldehyde 2′-quinolylhydrazone and 2′-pyridylhydrazone (PCPH) and the 6-, 3′-, 4′-, 5′-, and 6′-Me derivatives of PCPH) were prepared and characterized by magnetic susceptibility measurements down to liquid N temperature and also by electronic, IR, ESR and Moessbauer spectra. All MLX₂ are monomeric, high-spin, 5-coordinate (square-pyramidal) except for Ni(PCPH)Cl₂ which is polymeric, high-spin, 6-coordinate. Each ligand behaves as a tridentate NNN donor, via the pyridine N, azomethine N, and pyridine or quinoline N. One of the most active agents of this series, Cu(PCPH)Cl₂, showed antitumor activity against a variety of transplanted tumors, including Sarcoma 180, Ehrlich carcinoma and L1210 leukemia sensitive to α-(N)-heterocyclic carboxaldehyde thiosemicarbazones. This agent caused inhibition of ³H-thymidine and ³H-uridine incorporation into DNA and RNA, resp., of Sarcoma 180 ascites cells; protein biosynthesis was relatively insensitive to the action of this agent.

Inorganica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Green, R. W. published the artcileThermodynamics of chelation. I. Iron (II) and zinc (II) complexes of pyridine-2-carboxaldehyde 2′-pyridylhydrazone, Computed Properties of 2215-33-0, the publication is Australian Journal of Chemistry (1968), 21(5), 1165-73, database is CAplus.

In dilute solution, pyridine-2-carboxaldehyde 2′-pyridylhydrazone can behave as a diacid base or as a tridentate chelating agent. Its cationic bis complexes further undergo 2 stages of deprotonation. Equilibrium constants were measured at 7 temperatures from 5° to 60° and over a range of ionic strength. They have been used to derive values of enthalpies and entropies of reaction with H+, Fe2+, and Zn2+.

Australian Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Computed Properties of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pickart, Loren published the artcileInhibition of the growth of cultured cells and an implanted fibrosarcoma by aroylhydrazone analogs of the Gly-His-Lys-copper(II) complex, Category: pyridine-derivatives, the publication is Biochemical Pharmacology (1983), 32(24), 3868-71, database is CAplus and MEDLINE.

Both salicylaldehydebenzoylhydrazonato-Cu(II) chloride hydrate (I) [83614-45-3] and pyridine-2-carboxaldehyde-2-pyridylhydrazonato-Cu(II) dichloride (II) [46847-77-2] inhibited DNA formation in 6 types of human and mouse cultured cells (normal and neoplastic). The degree of inhibition by I or II was comparable to that obtained with cisplatin, bleomycin, and thiotepa. In vivo, I or II injection into the tumor area of mice implanted s.c. with MCA1511 fibrosarcoma resulted in marked tumor-size regression. I.p. treatment of the transplanted tumors was less effective in controlling tumor growth. The Cu-free ligands were inactive as antitumor agents. Thus, I and II, both analogs of Gly-His-Lys-Cu(II), are potent antimitotic and antineoplastic agents.

Biochemical Pharmacology published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hershko, Chaim published the artcilePhenolic ethylenediamine derivatives: a study of orally effective iron chelators, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Journal of Laboratory and Clinical Medicine (1984), 103(3), 337-46, database is CAplus and MEDLINE.

Of 35 potential iron chelators screened for in vivo activity in rats, a group of phenolic compounds with excellent chelating properties were identified. These included N,N‘-ethylene-bis(o-hydroxyphenylglycine) (EHPG) [1170-02-1], NN‘-Bis(o-hydroxybenzyl)-ethylenediamine diacetic acid (HBED) [303-38-8], and their resp. di-Me esters (dmEHPG [90044-13-6] and dmHBED [85120-52-1]. All 4 phenolic compounds produced a marked increase in the fecal excretion of hepatocellular radioiron. This amounted to 42% of total body radioactivity with dmEHPG, 58% with EHPG, 60% with HBED, and 80% with dmHBED after a single injection of 40 mg/animal. At a dose of 5 mg/animal, EHPG, HBED, and dmHBED were 9, 12, and 15 times more potent, resp., than deferoxamine. Both di-Me esters showed significant oral activity: oral dmEHPG retained 1/3 and dmHBED retained 2/3 of the effect of the same dose given by i.m. injection. The ester dmHBED combines oral effectiveness with superior chelating ability, selective hepatocellular action, and low apparent toxicity. It may represent a significant advance in the development of new iron-chelating drugs.

Journal of Laboratory and Clinical Medicine published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileIndirect spectrofluorometric kinetic determination of palladium and nickel based on the oxidation of 2,2′-dipyridylketone hydrazone and dipyridylglyoxal hydrazone, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1984), 359-64, database is CAplus.

Kinetic methods for Pd (0.1-0.8 mg L^-1) and Ni (0.1-0.7 mg L^-1) are based, resp., on the uncatalyzed bromate oxidation of 2,2′-dipyridylketone hydrazone (DPKH) in acidic media and of dipyridylglyoxal hydrazone (DPDKH) in basic media, to yield fluorescent products. Complexation of DPKH and DPDKH by Pd(II) and Ni(II), resp., causes a decrease in ligand concentration and thus in reaction rate, which can be related to the concentration of metal. The method for Pd is relatively free from interferences.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileEffect of surfactants on the fluorescence intensity of organic reagents, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Microchemical Journal (1985), 31(1), 44-9, database is CAplus.

The effect of 45 surfactants on the fluorescence intensity of 12 organic reagents was studied and is discussed. There is a marked enhancement in the fluorescence intensity of organic reagents with nonrigid structures and with Ph groups closely located.

Microchemical Journal published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cameron, Alan J. published the artcileColorimetric determination of palladium with pyridine-2-carboxaldehyde 2′-pyridylhydrazone, Related Products of pyridine-derivatives, the publication is Analytica Chimica Acta (1968), 40(3), 413-19, database is CAplus.

Pd can be determined colorimetrically by extraction of the 1:1:1 Pd(II)-chlorine-pyridine-2-carboxaldehyde 2′-pyridylhydrazone complex from an acidic aqueous solution into σ-dichlorobenzene and measurement of the absorbance of the extract solution The method is suitable for the determination of 10-110 μg. of Pd. Tolerance amounts for many metals have been determined and compare very favorably with those of other methods.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cameron, Alan John published the artcileMetal-pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes as visual acid-base indicators. I. Indicator constants, color changes, and titrations, Formula: C11H10N4, the publication is Analytica Chimica Acta (1970), 51(2), 249-56, database is CAplus.

The pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes of certain metals are suggested as acid-base indicators. The color change intervals of aqueous solutions of the complexes of Cu(II), Fe(II), Ni(II), Zn(II), and Cd(II) have been studied. Apparent indicator constants have been determined The performance of the indicators in titrns of weak and strong acids and bases is excellent.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cameron, Alan John published the artcileMetal-pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes as visual acid-base indicators. II. Extractive end point titrations and pH of extraction, Product Details of C11H10N4, the publication is Analytica Chimica Acta (1970), 51(2), 257-63, database is CAplus.

The pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes of Cu(II), Fe(II), and Ni(II) are very good indicators for extractive end points in acid-base titrations The pH ranges for extraction of the complexes have been established, and their relevance to the extractive end points is discussed.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcile2,2′-Dipyridyl ketone hydrazone as photometric reagent. Critical study of colorimetric and fluorimetric reaction ability of hydrazones, azines and phenylhydrazones of various ketones, Product Details of C11H10N4, the publication is Afinidad (1982), 39(377), 30-2, database is CAplus.

2,2′-Dipyridyl ketone hydrazone in EtOH reacts with Pd(II) to form a complex with absorption peak at 500 nm. The development of the color takes 30 min and is then stable for at least 2 h. Optimum conditions are pH 13.4 and 80% EtOH solvent. Beer’s law is followed for 0.5-4.0 ppm Pd. Tolerance levels for 21 ions are given. The colorimetric and fluorometric reactions of hydrazones, azine, and phenylhydrazones of various ketones are briefly reviewed.

Afinidad published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem