Category: 22961-45-1

Yang, Qin; Lei, Xiaoli; Yin, Zhijian; Deng, Zhihong; Peng, Yiyuan published the artcile< Copper-Catalyzed NaBAr4-Based N-Arylation of Amines>, Synthetic Route of 22961-45-1, the main research area is arylamine preparation; amine tetraaryl borate Cham Lam cross coupling copper catalyst.

NaBAr4 Based Cham-Lam cross-coupling of amines for the synthesis of arylamines RNHAr [R = n-Bu, Ph, benzyl, etc.; Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.] in the presence of catalytic copper (II) acetate monohydrate in acetonitrile at room temperature under air was described. In particular, the reaction of alkylamine and NaBAr4 proceeded smoothly to offered the corresponding products in good to excellent yields.

Synthesis published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Synthetic Route of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pratap, Ramendra; Yorimitsu, Hideki published the artcile< Palladium-Catalyzed Amination of Aryl Sulfides and Sulfoxides with Azaarylamines of Poor Nucleophilicity>, Recommanded Product: N-Phenylpyridin-4-amine, the main research area is heteroaryl amine preparation; sulfide aryl azaarylamine amination palladium catalyst; sulfoxide aryl azaarylamine amination palladium catalyst.

The amination of aryl sulfides and sulfoxides (Ar)2S and (Ar)2SO2 [Ar = C6H5, 2-naphthyl, biphenyl-4-yl, etc.] with azaarylamines R1NH2 (R1 = pyrimidin-2-yl, pyrazin-2-yl, quinolin-3-yl, etc.) is investigated using a palladium-N-heterocyclic carbene (NHC) complex I. Because azaarylamines are less nucleophilic than anilines, more reactive diaryl sulfides and sulfoxides are found to be suitable coupling partners that liberate better leaving arenethiolate or arenesulfenate anions, instead of aryl Me sulfides RSCH3 [R = 4-FC6H4, 2-naphthyl, 4-(2,5,5-trimethyl-1,3-dioxan-2-yl)phenyl, etc.] as reported previously.

Synthesis published new progress about Amination. 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Recommanded Product: N-Phenylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yu-Ling; Zhou, Bo-Wen; Cheng, Jie; Zhang, Fang; Zhang, Jing; Zhang, Li; Guo, Yin-Long published the artcile< Mass Spectrometry-Based Discovery of New Chemical Scaffold Rearrangement Ions: Aza-biphenylene as a Novel Potent Biradical Agent in Cancer Chemotherapy>, Recommanded Product: N-Phenylpyridin-4-amine, the main research area is azabiphenylene metabolite anticancer oxidative stress mass spectrometry.

Discovery of a new drug is time-consuming, laborious, and expensive. Herein, a novel integrative strategy for discovering potential new lead compounds has been developed, which was based on the characteristics of mass spectrometry (MS). MS was used to predict the potential forced degradation products (DPs) and metabolites of drugs by electrospray ionization and collision-induced dissociation (CID). Special rearrangement ions representing unique predicted DPs and metabolites were identified. The consistency between the predicted and the measured results was proven by in vitro metabolism and forced degradation of a com. drug, resp. From this, new chem. scaffold rearrangement ions named (aza)-biphenylenes, as potent anticancer agents, were discovered. As a representative aza-biphenylene analog, 2-azabiphenylene was proven in vitro to induce apoptosis and inhibit the growth of various human cancer cells in a dose-dependent manner. Surprisingly, 2-azabiphenylene exhibited the best comparable bioactivity with the pos. control sorafenib, but showed significantly lower in vitro cytotoxicity than sorafenib (at least a 5-fold decrease in cytotoxicity) because it could be targeted to the tumor microenvironment at low pH. A biradical mechanism accompanied by a mitochondrion-dependent oxidative stress mechanism was proposed to explore its anticancer mechanism. The highly reactive intermediate aza-biphenylenediyl worked as an active pharmaceutical ingredient and induced apoptosis of cancer cells. This provided the basis for the potential applications of CID-induced special rearrangement ions in developing new lead compounds

Analytical Chemistry (Washington, DC, United States) published new progress about Antitumor agents. 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Recommanded Product: N-Phenylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ando, Shin; Hirota, Yurina; Matsunaga, Hirofumi; Ishizuka, Tadao published the artcile< Nickel-catalyzed N-arylation of amines with arylboronic acids under open air>, COA of Formula: C11H10N2, the main research area is arylamine preparation; amine arylboronic acid Chan Lam coupling nickel catalyst.

Novel NHC-Ni complex was developed and used for the synthesis of arylamines via Chan-Lam coupling of amines with arylboronic acids. This novel NHC-Ni complex in combination with 4,4′-dimethyl-2,2′-bipyridine, however, proved to be an effective catalyst that lowered the required catalyst loading to only 2.0 mol%. The robustness of NHC complexes toward oxidative conditions and high level of σ-donating ability of NHC ligands could be reason for catalysis.

Tetrahedron Letters published new progress about Arylation. 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, COA of Formula: C11H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ren, Linning; Wang, Manman; Fang, Benyao; Yu, Wenquan; Chang, Junbiao published the artcile< Iodine-mediated oxidative N-N coupling of secondary amines to hydrazines>, Product Details of C11H10N2, the main research area is aromatic secondary amine iodine mediator oxidative dimerization; diaryl hydrazine preparation.

An I2-mediated N-N coupling reaction was established for oxidative dimerization of N-aryl aminopyridines to a variety of novel hydrazine derivatives under mild conditions. This synthetic method does not required the use of transition metals and was conveniently carried out on a gram scale. It was also applicable to diphenylamine and N-alkyl aniline substrates.

Organic & Biomolecular Chemistry published new progress about Hydrazines Role: SPN (Synthetic Preparation), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Product Details of C11H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Gaorong; Fu, Xiaopan; Wang, Yangyang; Deng, Kezuan; Zhang, Lili; Ma, Tao; Ji, Yafei published the artcile< C-H Borylation of Diphenylamines through Adamantane-1-carbonyl Auxiliary by BBr3>, Category: pyridine-derivatives, the main research area is ortho carbon hydrogen bond borylation phenylamine adamantanecarbonyl directed; isotope effect borylation kinetics phenylamine adamantanecarbonyl directed; boronate ester phenylamine derivative preparation reactivity; crystal structure chlorophenyl dioxaborolanylphenyl adamantanecarboxamide; mol structure chlorophenyl dioxaborolanylphenyl adamantanecarboxamide.

A method for ortho-C-H borylation of diphenylamines using BBr3 as the B source is reported. The noncatalytic adamantane-1-carbonyl directed reaction exhibited site exclusivity and good functional group tolerance. Generally, the borylation occurred at the more electron-rich aromatic ring and the borylated products could be converted to various useful intermediates. Besides, the derived arylation and removal of auxiliary of the product could be achieved in a 1-pot fashion.

Organic Letters published new progress about Addition reaction kinetics (borylation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Hongtai; Yang, Yanyan; Wang, Lianxin; Niu, Yuxiang; Guo, Minjie; Ren, Xiangwei; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published the artcile< Slicing and Splicing of Bromodifluoro-N-arylacetamides: Dearomatization and Difunctionalization of Pyridines>, Computed Properties of 22961-45-1, the main research area is copper catalyzed dearomatization functionalization pyridine bromodifluoroarylacetamide; fluoromethyl iminodihydropyridine synthesis.

Copper-catalyzed dearomatization and difunctionalization of pyridines have been disclosed, in which bromodifluoro-N-arylacetamide was sliced into five fragments and three or four of them were transferred to pyridine partners. Through this reaction, novel N-difluoromethyl-2-imine dihydropyridine derivatives can be conveniently accessed from com. available 4-amino substituted pyridines. This strategy demonstrates a novel fluorination method featuring high atom economy, environmental friendliness, an easily available catalyst, and simple operation.

Organic Letters published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Computed Properties of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Xia; Yang, Qiu-Xia; Long, Cheng-Yu; Tan, Yan; Qu, Yi-Xin; Su, Min-Hui; Huang, Si-Jie; Tan, Weihong; Wang, Xue-Qiang published the artcile< Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines>, Electric Literature of 22961-45-1, the main research area is heteroaryl alkyl ether amine nucleophilic amination; amine heteroaryl preparation anticancer activity green chem.

A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C-O bond cleavage, offering a new amination strategy to access several anticancer-active compounds This work is highlighted by the excellent functional group compatibility, scalability, wide substrate scope, and easy derivatization of a variety of drugs.

Organic Letters published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Electric Literature of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Wuchen; Wang, Meng; Yang, Siyu; Chen, Yadong; Feng, Jie; Huang, Yatian published the artcile< C-H chlorination of (hetero)anilines via photo/organo co-catalysis>, Computed Properties of 22961-45-1, the main research area is chloro aniline chemoselective preparation photochem; aniline carbon hydrogen chlorination catalyst tetra carbazolyl benzenedicarbonitrile chlorosuccinimide.

Herein, a photo-redox and organo co-catalyzed chlorination method for anilines to gave chloro-anilines ArNR1R2 [Ar = 4-ClC6H4, 3,4-di-Cl-5-FC6H2, 4-Cl-2,5-di-FC6H2, etc.; R1 = H, Me; R2 = H, Me, C(O)Me, Ph, pyrimidin-2-yl; R1R2 = (CH2)2N(CH3)(CH2)2] was disclose. This method had great substrate generality and excellent mono-chlorination selectivity. Another merit of this method was the late-stage modification of drug mols., which would be useful in medicinal chem.

Organic & Biomolecular Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Computed Properties of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem