Category: 23056-40-8

Related Products of 23056-40-8, Adding some certain compound to certain chemical reactions, such as: 23056-40-8, name is 2-Chloro-5-methyl-3-nitropyridine,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23056-40-8.

Synthesis of the compound 16 The compound 15 (3 g, 0.017 mol) was dissolved with agitation in a concentrated sulphuric acid (80 mL) in ice bath , the sodium dichromate (7.5 g, 0.025 mol) was added slowly in batches into the system, and the reaction was run at room temperature (25C) for 12 h. The above reaction liquid was added slowly into broken ice (50 g) and extracted with 50mL of ethyl acetate for three times. The extracts were combined, washed with a saturated aqueous solution of table salt, dried over anhydrous magnesium sulfate, and then was subject to filtration. The solvent was evaporated off and 2.9 g of the crude product was obtained with a yield of 82.8%. The crude product was recrystallized in ethanol to obtain 2.4 g of the solid product with a yield of 68.6 % and a melting point of 218C (ethanol)[J.O.C., 1985, 50, 1041].

According to the analysis of related databases, 23056-40-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Yiling Bioengineering Co., Ltd.; EP2366691; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 23056-40-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23056-40-8, name is 2-Chloro-5-methyl-3-nitropyridine, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 4 (1.0 g, 6.5 mmol) and c-H2SO4 (27 mL), sodium dichromate (2.5 g) was added slowly. After stirring at rt for 15 h, the mixture was slowly added into cracked ice. The mixture was extracted with EtOAC. The organic extract was washed with brine, dried over Na2SO4, and evaporated in vacuo to provide product 5 as a green solid (1.0 g, 85%). 1H NMR (300 MHz, DMSO-d6) delta: 13.32 (s, 1H), 8.64 (d, J = 2.4 Hz, 1H), 8.37 (d, J = 2.4 Hz, 1H).

According to the analysis of related databases, 23056-40-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhao, Chao; Yang, Su Hui; Khadka, Daulat Bikram; Jin, Yifeng; Lee, Kyung-Tae; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 985 – 995;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 23056-40-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23056-40-8, name is 2-Chloro-5-methyl-3-nitropyridine, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 4 (1.0 g, 6.5 mmol) and c-H2SO4 (27 mL), sodium dichromate (2.5 g) was added slowly. After stirring at rt for 15 h, the mixture was slowly added into cracked ice. The mixture was extracted with EtOAC. The organic extract was washed with brine, dried over Na2SO4, and evaporated in vacuo to provide product 5 as a green solid (1.0 g, 85%). 1H NMR (300 MHz, DMSO-d6) delta: 13.32 (s, 1H), 8.64 (d, J = 2.4 Hz, 1H), 8.37 (d, J = 2.4 Hz, 1H).

According to the analysis of related databases, 23056-40-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhao, Chao; Yang, Su Hui; Khadka, Daulat Bikram; Jin, Yifeng; Lee, Kyung-Tae; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 985 – 995;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem