With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23056-46-4, name is 2-Bromo-5-methyl-3-nitropyridine, molecular formula is C6H5BrN2O2, molecular weight is 217.02, as common compound, the synthetic route is as follows.Product Details of 23056-46-4
[00259] A round bottom flask was charged with 2-bromo-5-methyl-3- nitropyridine (60.53 g, 278.9 mmol) and CuCN (27.52 g, 307.3 mmol) The flask was evacuated, and back-filled with nitrogen. DMF (150 mL) was added via cannula. The solution was heated to 70 0C for 1.5 hours. After cooling to room temperature, the reaction mixture was poured into EtOAc (500 mL) and water (250 mL). Both phases were filtered through a 1 cm bed of celite. The layers were separated, and the organic phase washed with water (2 * 100 mL) then with a solution of 1 :1 sat. aq. NH4CI / NH4OH (2 x 100 mL). The combined aqueous layers were extracted with EtOAc (2 * 200 mL). The combined organic layers were dried over MgSO4 and concentrated in vacuo to afford the title compound (36.1Og, 79% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,23056-46-4, 2-Bromo-5-methyl-3-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; CHEMOCENTRYX, INC.; WO2009/9740; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem