Category: 24484-93-3

Armaghan, Mahsa published the artcileIsolation of first row transition metal-carboxylate zwitterions, Synthetic Route of 24484-93-3, the main research area is first row transition metal carboxylate zwitterion hydroxymethylpyridylbenzoate preparation; crystal structure first row transition metal carboxylate zwitterion hydroxymethylpyridylbenzoate.

Zwitterionic 3d metal carboxylates of Zn(II), Cu(II), Ni(II) and Co(II) were isolated and structurally authenticated by x-ray crystallog. 2-Hydroxymethylpyridine-carboxylate ligands with different sizes and shapes demonstrate variable coordination modes with first row transition metals under different conditions, yielding a class of 17 complexes, predominantly zwitterions. The nature of the ligands permits the carboxylates to be uncoordinated, anionic and conjugated, thereby balancing the pos. charges on the metal centers.

RSC Advances published new progress about Crystal structure. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Synthetic Route of 24484-93-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heerding, Dirk published the artcileSynthesis of a tritium labeled analog of the novel hematoregulatory agent SB 209978, Recommanded Product: Methyl 4-chloropicolinate, the main research area is SB 209978 tritium preparation; hematoregulatory agent tritium labeled preparation.

[3H]-SB 209978 (I, X = 3H) was synthesized in 6 steps from phenylene diamine dihydrochloride. A key aspect was the regioselective synthesis of 6-chloropicolinic acid. This was condensed with diamine II and the resulting product was deprotected to give I (X = Cl). Palladium catalyzed 3H-hydrogenolysis of the chloropyridine rings gave the final product I (3H).

Journal of Labelled Compounds & Radiopharmaceuticals published new progress about SB 209978 tritium preparation; hematoregulatory agent tritium labeled preparation. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Recommanded Product: Methyl 4-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sanders, Georgine M. published the artcileReactions of haloquinolizinium bromides with diethylamine, Formula: C7H6ClNO2, the main research area is quinolizinium bromide diethylamine reaction.

The reactions of quinolizinium bromide (QB) and its four monobromo derivatives with diethylamine have been investigated. For Br in position 2 or 4, substitution is the main process, whereas for Br in positions 1 and 3 quant. ring opening is found. The substituted pyridylbutadienes formed by ring opening, are cis-trans-butadienes, which isomerize into the all-trans forms. The steric course of the ring opening is explained.

Journal of Heterocyclic Chemistry published new progress about quinolizinium bromide diethylamine reaction. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Formula: C7H6ClNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gudmundsson, Kristjan S. published the artcileAn improved large-scale synthesis of 2-amino-4-chloropyridine and its use for the convenient preparation of various polychlorinated 2-aminopyridines, Recommanded Product: Methyl 4-chloropicolinate, the main research area is aminochloropyridine preparation chlorination; polychlorinated aminopyridine preparation; pyridine amino polychlorinated preparation.

An efficient large scale synthesis of 2-amino-4-chloropyridine (I) has been achieved through a modification of existing literature procedures. I was used to prepare the previously unreported 2-amino-4,5-dichloropyridine. The known 2-amino-3,4-dichloropyridine and 2-amino-3,4,5-trichloropyridine were prepared from I by new routes and in higher yields than previously reported.

Synthetic Communications published new progress about aminochloropyridine preparation chlorination; polychlorinated aminopyridine preparation; pyridine amino polychlorinated preparation. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Recommanded Product: Methyl 4-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

De Roos, K. B. published the artcileDeazapurine derivatives. V. New synthesis of 1- and 3-deaza-adenine and related compounds, Product Details of C7H6ClNO2, the main research area is adenines deaza; deazaadenines; imidazopyridines; pyridines imidazo; purines deaza.

Reinvestigation of the cyclization of 2,3,4-triaminopyridine by several procedures showed that both 7-aminoimidazo[4,5-b]pyridine (1-deaza-adenine) (I) and 4-aminoimidazo[4,5-c]pyridine (3-deazaadenine) (II) were always obtained. A new and convenient route to the synthesis of I was devised. An unambiguous synthesis of II is given. Ring closure of 2,4,5-triaminopyridine afforded 6-aminoimidazo[4,5-c]pyridine (3-deazaisoadenine).

Recueil des Travaux Chimiques des Pays-Bas published new progress about adenines deaza; deazaadenines; imidazopyridines; pyridines imidazo; purines deaza. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Product Details of C7H6ClNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Asakawa, Chiharu published the artcile[11C]Sorafenib: Radiosynthesis and preliminary PET study of brain uptake in P-gp/Bcrp knockout mice, Application of Methyl 4-chloropicolinate, the main research area is carbon 11 sorafenib preparation PET imaging brain.

Sorafenib (Nexavar, BAY43-9006, 1) is a second-generation, orally active multikinase inhibitor that is approved for the treatment of some cancers in patients. In this Letter, we developed [11C]1 as a novel positron emission tomog. (PET) probe, and evaluated the influence of ABC transporters-mediated efflux on brain uptake using PET with [11C]1 in P-glycoprotein (P-gp)/breast cancer resistance protein (Bcrp) knockout mice vs. wild-type mice. [11C]1 was synthesized by the reaction of hydrochloride of aniline 2 with [11C]phosgene ([11C]COCl2) to give isocyanate [11C]6, followed by reaction with another aniline 3. Small-animal PET study with [11C]1 indicated that the radioactivity level (AUC0-60 min, SUV × min) in the brains of P-gp/Bcrp knockout mice was about three times higher than in wild-type mice.

Bioorganic & Medicinal Chemistry Letters published new progress about Brain. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Application of Methyl 4-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hansen, Helge-Boj published the artcileThe Stronger the Better: Donor Substituents Push Catalytic Activity of Molecular Chromium Olefin Polymerization Catalysts, Category: pyridine-derivatives, the main research area is donor substituents chromium; chromium, ligand effects, olefin polymerization, supported catalysts, UHMW-PE.

The donor strength of bifunctional pyridine-cyclopentadienyl ligands was altered systematically by the introduction of donating groups in the para-position of the pyridine. In the resulting chromium complexes an almost linear correlation between donor strength and the nitrogen-chromium distance as well as the electronic absorption maximum is exptl. observed The connection of electron-donating groups in the ligand backbone leads to an efficient transfer of the electronic influences to the catalytically active metal center without restricting it through steric effects. Therefore, catalytic olefin polymerization activity, which is already very high for the previously studied catalysts, increase considerably by attaching para-amino groups to the chelating pyridine or quinoline, resp. Combining electron-rich indenyl ligands with para-amino substituted pyridines lead to the highest catalytic activities observed so far for this class of organo chromium olefin polymerization catalysts. The resulting polymers are of ultra-high mol. weight and the ability of the catalysts to incorporate co-monomers is also very high.

Chemistry – A European Journal published new progress about Crystal structure. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Chengwei published the artcileStudy on Typical Diarylurea Drugs or Derivatives in Cocrystallizing with Strong H-Bond Acceptor DMSO, Name: Methyl 4-chloropicolinate, the main research area is diarylurea drug derivative cocrystn DMSO.

Diarylureas are widely used in self-assembly and supramol. chem. owing to their outstanding characteristics as both H-bond donors and acceptors. Unfortunately, this bonding property is rarely applied in the development of urea-containing drugs. Herein, seven related DMSO complexes were screened from 12 substrates involving sorafenib and regorafenib, mainly considering the substitution effect following a robust procedure. All complexes were structurally confirmed by spectroscopic means and thermal anal. Specially, five cocrystals with three deuterated, named sorafenib·DMSO, donafenib·DMSO, deuregorafenib·DMSO, 6·DMSO, and 7·DMSO were obtained. The crystal structures revealed that all host mols. consistently bonded with DMSO in intermol. interaction in a 1:1 stoichiometry. However, further comparison with documented DMSO complexes and parent motifs presented some arrangement diversities especially for 6·DMSO which offered a counter-example to previous rules. Major changes in the orientation of meta-substituents and the packing stability for sorafenib·DMSO and deuregorafenib·DMSO were rationalized by theory anal. and computational energy calculation Cumulative data implied that the planarization of two aryl planes in diarylureas may play a crucial role in cocrystn. Also, a polymorph study bridged the transformation between these ureas and their DMSO complexes.

ACS Omega published new progress about Cocrystallization. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Name: Methyl 4-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ma, Jiajia published the artcileFacile access to fused 2D/3D rings via intermolecular cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinolines with alkenes, Formula: C7H6ClNO2, the main research area is quinoline alkene iridium photochem diastereoselective intermol dearomative cycloaddition rearrangement; azatetracyclododecatriene preparation; tetrahydro benzocyclobutapyridine preparation.

Two types of energy-transfer-mediated cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinoline derivatives with alkenes, which provide a straightforward avenue to 2D/3D pyridine-fused 6-5-4-3- and 6-4-6-membered ring systems are reported. Notably, this energy-transfer-mediated strategy features excellent diastereoselectivity that bypasses the general reactivity and selectivity issues of photochem. [2+2] cycloaddition of various other aromatics Tuning the aza-arene substitutions enabled selective diversion of the iridium photocatalyzed energy transfer manifold towards either cyclopropanation or cyclobutane-rearrangement products. D. functional theory calculations revealed a cascade energy transfer scenario to be operative.

Nature Catalysis published new progress about [2+2] Cycloaddition reaction catalysts (stereoselective,photochem.). 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Formula: C7H6ClNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Puvvala, Srinu published the artcileOne-Pot Synthesis of 7-chloro-2-arylthieno[3,2-b]pyridin-3-ols and Their Derivatization to the Corresponding Arylamino, Arylthio, and Aryloxy Derivatives, Recommanded Product: Methyl 4-chloropicolinate, the main research area is chloroarylthienopyridinol arylamino arylthio aryloxy derivative preparation.

A simple and efficient domino reaction for synthesis of 7-chloro-2-arylthieno[3,2-b]pyridin-3-ols followed by derivatization into their corresponding aminoaryl, aryloxy , and thioaryloxy derivatives is presented. The synthesis includes thioalkylation on 3-position of Me 4-chloropicolinate followed by in situ cyclization to give 7-chloro-2-arylthieno[3,2-b]pyridin-3-ols. The substitution of the chloro group with amines, phenols and thiophenols afforded the corresponding derivatives

Journal of Heterocyclic Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Recommanded Product: Methyl 4-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem