Category: 24517-64-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24517-64-4, name is 2-Amino-3-cyanopyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Amino-3-cyanopyridine

Synthesis of imidazo [1 ,2-a]pyridine- 8-carbonitrile. To a solution of 2-aminonicotinonitrile (1.0 g, 8.39 mmol) in EtOH (10 ml) in a 20m1 sealed vialwas added 2-chloroacetaldehyde (1.611 ml, 9.23 mmol) vial was then sealed and heated to 120C overnight. Reaction was cooled to RT and quenched with 2N Na2CO3, removed EtOH invaccuo and extracted with DCMx3. Combined organics and washed with water then brinex2.Dired over sodium sulfate and removed solvent to give title compound as a yellow brown solid(1.2 g, 8.38 mmol, 100 % yield) was verified by MS (ES+) C8H5N3 requires: 143 found: 144 [M+H]

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Reference:
Patent; BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.; WO2014/11900; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 24517-64-4, Adding some certain compound to certain chemical reactions, such as: 24517-64-4, name is 2-Amino-3-cyanopyridine,molecular formula is C6H5N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24517-64-4.

8.1 Compound 9: 2-Aminonicotinonitrile 8 (100 g, 0.839 mol) was dissolved in HOAc (800 mL) . To the solution was added Na2C03 (88.97 g, 0.839 mol). Then, Br2 (46.4 mL, 0.923 mol) was added dropwise. The reaction mixture was stirred at room temperature for 50 min. To the mixture was added water (600 mL) . The mixture was cooled to about 5C. The precipitate thus formed was collected by filtration and dried to give compound 9 (207 g, 96%) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 24517-64-4, 2-Amino-3-cyanopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; ABUDUSAIMI, Mamuti; YE, Fangguo; SUN, Jiangqin; MIYAMOTO, Hisashi; CHENG, Jay-Fei; OKA, Daisuke; WO2013/29548; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem