Category: 2459-07-6

Electric Literature of 2459-07-6 , The common heterocyclic compound, 2459-07-6, name is Methyl picolinate, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A suspension of methyl picolinate (6 g, 0.043 mol, 1 equiv) and hydrazine hydrate (4.3 g, 0.08 mol, 2.0 equiv) in EtOH (50 ml) was stirred at 90C for ovemignt. Product formation was confirmed by TLC and LCMS. The resulting mixture was concentrated under reduced pressure, the residue was dissolved in ethyl acetate and distilled water. Organic phase was separated, dried over anhydrous Na2S04 and it was concentrated under reduced pressure to give crude. The crude product was washed with diethyl ether to obtain picolinohydrazide (5.2 gm, as off white solid). ‘H NMR (400MHz, DMSO-ri6) d = 9.87 (br. s., 1H), 8.61 (d,.7= 4.8 Hz, 1H), 8.03 – 7.90 (m, 2 H), 7.57 (dt, J = 3.3, 5.2 Hz, 1H), 4.62 (br. s., 2 H).

The synthetic route of 2459-07-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRAXIS BIOTECH LLC; ALFARO, Jennifer; BELMAR, Sebastian; NUNEZ VASQUEZ, Gonzalo Esteban; PUJALA, Brahmam; SATHE, Balaji Dashrath; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; THAKRAL, Pooja; PATIDAR, Rajesh Kumar; (344 pag.)WO2019/195810; (2019); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 2459-07-6, Adding some certain compound to certain chemical reactions, such as: 2459-07-6, name is Methyl picolinate,molecular formula is C7H7NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2459-07-6.

To a 500 mL three neck round-bottomed flask equipped with a mechanical stirrer, a reflux condenser, and a nitrogen inlet/outlet was added methyl picolinate (40 g, 0.292 mol), hydrazine hydrate (17.5 g, 0.35 mol) and ethanol (120 mL). The resulting mixture was heated under reflux for 1 h. The solvent was removed under reduced pressure and the resulting residue dried to give the product 40 g (0.292 mol, 100%) as a white solid. 1H NMR (400 MHz, CDCl3) 8.99 (br s, 1H, -N-H), 8.51 (m, 1H, Ar-H), 8.13 (m, 1H, Ar-H), 7.82 (m, 1H, Ar-H), 7.40 (m, 1H, Ar-H) 4.08 (br s, 2H, -NH2).

According to the analysis of related databases, 2459-07-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CYTEC INDUSTRIES INC.; THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH; ROEBUCK, James William; SASSI, Thomas; FISCHMANN, Adam James; GRIFFIN, Violina; TASKER, Peter Anthony; (28 pag.)US2016/244860; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem