Category: 2459-09-8

Chemistry is an experimental science, Name: Methyl isonicotinate, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2459-09-8, Name is Methyl isonicotinate, molecular formula is C7H7NO2, belongs to pyridine-derivatives compound. In a document, author is Chen, I-Ni.

Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells

Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that ((LTi)-L-H-Ti-Me-O)(4) (IC50 = 0.91 mu M) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2459-09-8, in my other articles. Name: Methyl isonicotinate.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 2459-09-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2459-09-8, name is Methyl isonicotinate, molecular formula is C7H7NO2, molecular weight is 137.136, as common compound, the synthetic route is as follows.

Step 1. Synthesis of methyl 2-(hydroxymethyl)isonicotinate (59):A solution of methyl isonicotinate (58; 70 grams 0.5 mol), ammonium peroxodisulfate (233 grams, 1.02 mol), and cone, sulfuric acid (5 mL) in methanol (600 mL) was refluxed until starting material was consumed. The reaction was concentrated, water was added and the solution was neutralized to pH=9 with K2CO3. The resulting aqueous solution was extracted with ethyl acetate, and the extracts were concentrated, stirred with petroleum ether for 1 hour and the solids were collected by filtration to obtain 15 grams (18% yield) of 2- (hydroxymethyl)isonicotinate 59.

Statistics shows that 2459-09-8 is playing an increasingly important role. we look forward to future research findings about Methyl isonicotinate.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; NARAYAN, Radha; DISCH, Jeremy, S.; PERNI, Robert, B.; VU, Chi, B.; WO2010/56549; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem