Category: 2510-22-7

Application of 2510-22-7In 2020 ,《Confinement Self-Assembly of Metal-Organic Cages within Mesoporous Carbon for One-Pot Sequential Reactions》 appeared in Chem. The author of the article were Zhu, Fan-Fan; Chen, Li-Jun; Chen, Shangjun; Wu, Gui-Yuan; Jiang, Wei-Ling; Shen, Ji-Chuang; Qin, Yi; Xu, Lin; Yang, Hai-Bo. The article conveys some information:

Herein, the first successful confinement self-assembly of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)-containing metal-organic cages within amino-functionalized mesoporous carbon to realize a new family of bifunctional heterogeneous catalyst (Cage@FDU-ED) for one-pot sequential oxidation/Knoevenagel condensation reactions of alcs. RCH2OH (R = 4-nitrophenyl, naphthalen-1-yl, cyclohexylmethyl, etc.) was presented. The orthogonal features of the isolated catalytically active sites within the obtained bifunctional catalyst lead to enhanced catalytic activities, selectivity, and recyclability with the overall transformation yielding up to 96% conversion. These results demonstrate that continuous chem. transformation with high efficiency is possible through careful design of catalytic sites in both metal-organic cages and mesoporous matrix isolatedly. This study paves a new way toward metal-organic cages as a promising platform for heterogeneous sequential reactions. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A Comparative Investigation of the Role of the Anchoring Group on Perylene Monoimide Dyes in NiO-Based Dye-Sensitized Solar Cells》 was written by Farre, Yoann; Maschietto, Federica; Foehlinger, Jens; Wykes, Mike; Planchat, Aurelien; Pellegrin, Yann; Blart, Errol; Ciofini, Ilaria; Hammarstroem, Leif; Odobel, Fabrice. Application In Synthesis of 4-Ethynylpyridine And the article was included in ChemSusChem in 2020. The article conveys some information:

The anchoring group of a sensitizer may strongly affect the overall properties and stability of the resulting dye-sensitized solar cells (DSSCs) and dye-sensitized photoelectrosynthetic solar cells (DSPECs). The properties of seven perylene monoimide (PMI) dyes have been comprehensively studied for their immobilization on nanocrystalline NiO film. The PMI dyes differ only by the nature of the anchoring group, which are: carboxylic acid (PMI-CO2H), phosphonic acid (PMI-PO3H2), acetyl acetone (PMI-acac), pyridine (PMI-Py), aniline (PMI-NH2), hydroxyquinoline (PMI-HQ), and dipicolinic acid (PMI-DPA). The dyes are investigated by cyclic voltammetry and spectroelectrochem. and modeled by TD-DFT quantum chem. calculations The mode of binding of these anchoring groups is investigated by IR spectroscopy and the stability of the binding to NiO surface is studied by desorption experiments in acidic and basic media. The phosphonic acid group is found to offer the strongest binding to the NiO surface in terms of stability and dye loading. Finally, a photophys. study by ultrafast transient absorption spectroscopy shows that all dyes inject a hole in NiO with rate constants on a subpicosecond timescale and display similar charge recombination kinetics. The photovoltaic properties of the dyes show that PMI-HQ and PMI-acac give the highest photovoltaic performances, owing to a lower degree of aggregation on the surface. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wu, Yao; Xie, Mo; Jin, Ji-Kang; Zhang, Zhi-Yin; Hu, Han; Tian, You-Ping; Xiao, Yu-Qing; Ning, Guo-Hong; Li, Dan; Jiang, Xuanfeng published an article in Small Structures. The title of the article was 《A Copper Iodide Cluster-Based Metal-Organic Polyhedra for Photocatalytic Click Chemistry》.Electric Literature of C7H5N The author mentioned the following in the article:

Herein, a copper(I) iodide cluster-based metal-organic polyhedra (Cu3I3)4L14 (1) ((L1 = 1,3,5-trispyridylsulfanylethyl)-2,4,6-triethylbenzene, 2-mercaptopyridine) is synthesized. Due to the abnormal geometry of [Cu3I3] SBUs, MOP 1 exhibits a half-truncated cube topol., which is rarely observed up to date. Compared with commonly used metal ion or clusters, the coordination bond between the [Cu3I3] SBU and the ligand is rather labile in solution evidenced by the theor. calculations and exptl. results. Interestingly, the liable [Cu3I3] SBU endows MOP 1 to photocatalyze the azide-alkyne cycloaddition reaction in aqueous solution with high efficiency, excellent tolerance (>80% isolated yield for 18 examples), and good recyclability. The mechanistic studies reveal a photoinduced electron transfer from the MOP to azide, which is unusual in copper-catalyzed click reactions. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Electric Literature of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Electric Literature of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Ran; Wang, Lu; An, Zhongwei; Chen, Xinbing; Chen, Pei published an article in 2021. The article was titled 《Effect of π-conjugation units on the liquid crystal and photovoltaic performance of heterocyclic pyridine-based compounds》, and you may find the article in Liquid Crystals.Computed Properties of C7H5N The information in the text is summarized as follows:

A series of new calamitic liquid crystals (LCs), 4-(5-((4-(2-(trans-4-n-alkyl- cyclohexyl)ethyl)phenyl)ethynyl)-thiophen-2-yl)pyridine comprising a cyclohexyl, a Ph and two heterocyclic (pyridine and thiophene) ring core system, terminal alkyl chain, ethane and acetylene linkers were synthesized and characterised. Their structures were confirmed by IR spectrometry (IR), NMR (NMR) and mass spectrometry (MS), and the LC properties were investigated through differential scanning calorimetry (DSC) and polarising optical microscopy (POM). Dye-sensitized solar cells (DSSCs) were assembled to evaluate the photovoltaic properties of these materials. Furthermore, three compounds and have successfully been utilized to study the effect of π-conjugation units on the LCs properties and photovoltaic performance. The results show that thienyl unit instead of Ph unit benefits photovoltaic performance, while it is not favorable to the stability of the nematic mesophase and birefringence. Meanwhile, DFT calculations of mol. conformation, frontier MO and dipole moment were used to correlate the exptl. findings.4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Niu, Niu; Yu, Ying; Zhang, Zhijun; Kang, Miaomiao; Wang, Lei; Zhao, Zheng; Wang, Dong; Tang, Ben Zhong published an article in 2022. The article was titled 《A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics》, and you may find the article in Chemical Science.SDS of cas: 2510-22-7 The information in the text is summarized as follows:

The exploration of cellular organelle-specific anchoring photosensitizers with both prominent fluorescence imaging behavior and extraordinary reactive oxygen species (ROS) production capability is highly in demand but remains a severe challenge for effective cancer theranostics involving photodynamic therapy (PDT). In this contribution, we developed a cell membrane-targeting and NIR-emission photosensitizer having an aggregation-induced emission (AIE) tendency. The AIE photosensitizer, namely TBMPEI, is capable of lighting up and ablating cancer cells by means of a necroptosis procedure enabling cell membrane rupture and DNA degradation upon light irradiation, endowing TBMPEI with impressive performance for both in vitro and in vivo fluorescence imaging-guided PDT. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Stereochemistry of the α-carbon in the benzylic modifying moiety attached at the C-5 end of thymidine affects the potency of a newly identified anti-cancer lead nucleoside》 was published in Tetrahedron in 2020. These research results belong to Bercz, Aron P.; McClure, W. Andrew; English, Michael; Keebaugh, Michael W.; Litosh, Vladislav A.. Product Details of 2510-22-7 The article mentions the following:

The bioactivity of antimetabolites is connected to mol. recognition by the target proteins, which makes the stereochem. configuration of the chiral centers in these mols., including those in the modifying moieties, of extreme importance. In an attempt to enhance the anti-cancer activity of a newly identified 5-[(R/S-α-tert-butyl-2-nitro-4-{2-phenyl}alkynyl)benzyloxy]methyl-2′-deoxyuridine, initially evaluated as a 1:1 mixture of diastereomers with respect to the modifying moiety, we first took the excision library approach, which revealed the importance of all the structural features of the moiety for bioactivity. We then proceeded with the synthesis of the secondary derivatives, varying the substitution pattern within the moiety. These attempts failed to improve bioactivity. However, examination of individually made stereoisomers revealed a 3-fold potency increase in the S-isomer compared with the diastereomeric mixture, without significantly affecting the toxicity against normal rapidly dividing cells. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7Product Details of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lai, Yin-Long; Yan, Shaoxi; He, Dan; Zhou, Li-Zhen; Chen, Zi-Shen; Du, Yu-Long; Li, Jianxiao published their research in RSC Advances in 2021. The article was titled 《Palladium-catalyzed bisthiolation of terminal alkynes for the assembly of diverse (Z)-1,2-bis(arylthio)alkene derivatives》.Application of 2510-22-7 The article contains the following contents:

An efficient and straightforward palladium-catalyzed three-component cascade bisthiolation of terminal alkynes RCCH (R = n-Pr, Ph, cyclohexyl, 2-thienyl, etc.) and arylhydrazines ArNH2NH2.HCl (Ar = Ph, 4-fluorophenyl, 3-thienyl, etc.) with sodium thiosulfate (Na2S2O3) as the sulfur source for the assembly of functionalized (Z)-1,2-bis(arylthio)alkene derivatives RC(SAr)=CH(SAr) is described. Using 0.5 mol% IPr-Pd-Im-Cl2 as the catalyst, a wide range of terminal alkynes and arylhydrazines are well tolerated, thus producing the desired products in good yields with good functional group tolerance and excellent regioselectivity. Moreover, this protocol could be readily scaled up, showing potential applications in organic synthesis and material science. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Fischer, Christian; Veprek, Nynke A.; Peitsinis, Zisis; Ruhmann, Klaus-Peter; Yang, Chao; Spradlin, Jessica N.; Dovala, Dustin; Nomura, Daniel K.; Zhang, Yingkai; Trauner, Dirk published an article in Synlett. The title of the article was 《De novo Design of SARS-CoV-2 Main Protease Inhibitors》.Related Products of 2510-22-7 The author mentioned the following in the article:

The COVID-19 pandemic prompted many scientists to investigate remedies against SARS-CoV-2 and related viruses that are likely to appear in the future. As the main protease of the virus, M Pro, is highly conserved among coronaviruses, it has emerged as a prime target for developing inhibitors. Using a combination of virtual screening and mol. modeling, we identified small mols. that were easily accessible and could be quickly diversified. Biochem. assays confirmed a class of pyridones as low micromolar noncovalent inhibitors of the viral main protease. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Exploring antiaromaticity in single-molecule junctions formed from biphenylene derivatives》 were Gantenbein, Markus; Li, Xiaohui; Sangtarash, Sara; Bai, Jie; Olsen, Gunnar; Alqorashi, Afaf; Hong, Wenjing; Lambert, Colin J.; Bryce, Martin R.. And the article was published in Nanoscale in 2019. Related Products of 2510-22-7 The author mentioned the following in the article:

We report the synthesis of a series of oligophenylene-ethynylene (OPE) derivatives with biphenylene core units, designed to assess the effects of biphenylene antiaromaticity on charge transport in mol. junctions. Analogs with naphthalene, anthracene, fluorene and biphenyl cores are studied for comparison. The mols. are terminated with pyridyl or methylthio units. Single-mol. conductance data were obtained using the mech. controllable break junction (MCBJ) technique. It is found that when electrons pass from one electrode to the other via a phenylene ring, the elec. conductance is almost independent of the nature of the pendant π-systems attached to the phenylene ring and is rather insensitive to antiaromaticity. When electrons pass through the cyclobutadiene core of the biphenylene unit, transport is sensitive to the presence of the relatively weak single bonds connecting the two phenylene rings of biphenylene, which arise from partial antiaromaticity within the cyclobutadiene core. This leads to a negligible difference in the mol. conductance compared to the fluorene or biphenyl analogs which have standard single bonds. This ability to tune the conductance of mol. cores has no analog in junctions formed from artificial quantum dots and reflects the quantum nature of electron transport in mol. junctions, even at room temperature In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Dahiya, Amit; Schoenebeck, Franziska published an article in Organic Letters. The title of the article was 《Direct C-H Dehydrogenative Germylation of Terminal Alkynes with Hydrogermanesã€?Computed Properties of C7H5N The author mentioned the following in the article:

A direct C(sp)-H germylation of terminal alkynes with tri-Et Ge hydride is reported. The method is operationally simple and makes use of B(C6F5)3 catalysis in combination with 2,6-lutidine as an organic base. Exclusive selectivity for dehydrogenative germylation of the alkyne over the competing hydrogermylation is observed The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem