Category: 2510-22-7

《Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress》 was written by Zhuang, Zeyan; Dai, Jun; Yu, Maoxing; Li, Jianqing; Shen, Pingchuan; Hu, Rong; Lou, Xiaoding; Zhao, Zujin; Tang, Ben Zhong. HPLC of Formula: 2510-22-7 And the article was included in Chemical Science in 2020. The article conveys some information:

Photodynamic therapy is considered a pioneering and effective modality for cancer treatment, but it is still facing challenges of hypoxic tumors. Recently, Type I PDT, as an effective strategy to address this issue, has drawn considerable attention. Few reports are available on the capability for Type I reactive oxygen species (ROS) generation of purely organic photosensitizers (PSs). Herein, we report two new Type I PSs, α-TPA-PIO and β-TPA-PIO, from phosphindole oxide-based isomers with efficient Type I ROS generation abilities. A detailed study on photophys. and photochem. mechanisms is conducted to shed light on the mol. design of PSs based on the Type I mechanism. The in vitro results demonstrate that these two PSs can selectively accumulate in a neutral lipid region, particularly in the endoplasmic reticulum (ER), of cells and efficiently induce ER-stress mediated apoptosis and autophagy in PDT. In vivo models indicate that β-TPA-PIO successfully achieves remarkable tumor ablation. The ROS-based ER stress triggered by β-TPA-PIO-mediated PDT has high potential as a precursor of the immunostimulatory effect for immunotherapy. This work presents a comprehensive protocol for Type I-based purely organic PSs and highlights the significance of considering the working mechanism in the design of PSs for the optimization of cancer treatment protocols. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7HPLC of Formula: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 2510-22-7In 2020 ,《Synthesis and Optical Properties of Quadrupolar Pyridinium Salt and Its Application as Bioimaging Agent》 appeared in Chemistry Letters. The author of the article were Hoshi, Keita; Sanagawa, Yohei; Umebayashi, Ryuta; Tabata, Atsushi; Nagamune, Hideaki; Hase, Eiji; Minamikawa, Takeo; Yasui, Takeshi; Yoshida, Yasushi; Minagawa, Keiji; Kawamura, Yasuhiko; Imada, Yasushi; Yagishita, Fumitoshi. The article conveys some information:

We have synthesized and characterized an acceptor-π-donor-π-acceptor type pyridinium salt. The salt exhibited yellow emission with large Stokes shift in solution and was successfully excited by NIR irradiation via two-photon absorption process. In addition, it was found that the usage of the salt as a bioimaging agent for HeLa cells visualizes cell death. The combined use of the salt and a com. available green fluorescent dye for the detection of live cell viability realized the one-shot fluorescence imaging of live and dead HeLa cells under the single blue excitation. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C7H5NIn 2019 ,《Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes》 was published in Organic Letters. The article was written by Zhao, Chuan-Qi; Chen, Yue-Gang; Qiu, Hui; Wei, Lei; Fang, Ping; Mei, Tian-Sheng. The article contains the following contents:

Palladium-catalyzed transfer semihydrogenation of alkynes using H2O as the hydrogen source and Mn as the reducing reagent is developed, affording cis- and trans-alkenes selectively under mild conditions. In addition, this method provides an efficient way to access various cis-1,2-dideuterioalkenes and trans-1,2-dideuterioalkenes by using D2O instead of H2O. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Synthetic Route of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Messa, Francesco; Dilauro, Giuseppe; Paparella, Andrea Nicola; Silvestri, Lavinia; Furlotti, Guido; Iacoangeli, Tommaso; Perrone, Serena; Salomone, Antonio published an article in Green Chemistry. The title of the article was 《Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C》.Product Details of 2510-22-7 The author mentioned the following in the article:

A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodol. has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Product Details of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Lee, Yujeong; Onishi, Yoshiyuki; McPherson, Lisa; Kietrys, Anna M.; Hebenbrock, Marian; Jun, Yong Woong; Das, Ishani; Adimoolam, Shanthi; Ji, Debin; Mohsen, Michael G.; Ford, James M.; Kool, Eric T. published an article in ACS Chemical Biology. The title of the article was 《Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1》.SDS of cas: 2510-22-7 The author mentioned the following in the article:

Here, it is reported that selected tyrosine kinase (TK) inhibitors including nilotinib, employed clin. in the treatment of chronic myeloid leukemia, are activators of the repair enzyme Human MutT Homolog 1 (MTH1). MTH1 cleanses the oxidatively damaged cellular nucleotide pool by hydrolyzing the oxidized nucleotide 8-oxo-2′-deoxyguanosine (8-oxo-dG)TP, which is a highly mutagenic lesion when incorporated into DNA. Structural optimization of analogs of TK inhibitors resulted in compounds such as SU0448, which induces 1000 +/- 100% activation of MTH1 at 10μM and 410 +/- 60% at 5μM. The compounds are found to increase the activity of the endogenous enzyme, and at least one (SU0448) decreases levels of 8-oxo-dG in cellular DNA. The results suggest the possibility of using MTH1 activators to decrease the frequency of mutagenic nucleotides entering DNA, which may be a promising strategy to suppress tumorigenesis in individuals with elevated cancer risks. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-EthynylpyridineIn 2022 ,《Fuel Acid Drives Base Catalysis and Supramolecular Cage-to-Device Transformation under Dissipative Conditions》 appeared in Organic Letters. The author of the article were Mondal, Debabrata; Ghosh, Amit; Paul, Indrajit; Schmittel, Michael. The article conveys some information:

In State-I, a mixture comprising a DABCO-bridged tris(zinc-porphyrin) double decker and a free biped (=slider), catalysis was OFF. Acid addition (TFA or Di-Stefano fuel acid) to State-I liberated DABCO-H+ while generating a highly dynamic slider-on-deck device (State-II). The released DABCO-H+ acted as a base organocatalyst for a Knoevenagel reaction (catalysis ON). The system was reversed to State-I (catalysis OFF) by reducing the acidity in the system (by adding DBU or via the fuel-derived base). In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Decarboxylative Hydroalkylation of Alkynes via Dual Copper-Photoredox Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Mastandrea, Marco M.; Canellas, Santiago; Caldentey, Xisco; Pericas, Miquel A.. Recommanded Product: 2510-22-7 The article mentions the following:

A photoredox strategy for the synthesis of a wide range of allylic amines and ethers from carboxylic acids and alkynes has been developed. This approach relies on the perturbation of the ground-state electronic properties of terminal alkynes through the formation and photoexcitation of copper acetylide intermediates. This process takes place through cooperative copper and organic photoredox catalysis and can be carried out in a stereodivergent manner. Thus, a systematic multivariate HTE screening spotlighted that a switch in the stereochem. outcome can be provoked by choosing an appropriate combination of ligand and base. The developed methodol. has been applied to the stereoselective coupling of primary, secondary, and tertiary alkyl radicals with (hetero)aromatic terminal alkynes. As an addnl. practicality, similar reaction conditions allowed for the use of aromatic amines as radical precursors in a cross dehydrogenative coupling for the direct vinylation of inactivated C-H bonds. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis, characterization of peripherally tetra-pyridine-triazole-substituted phthalocyanines and their inhibitory effects on cholinesterases (AChE/BChE) and carbonic anhydrases (hCA I, II and IX)》 was published in Dalton Transactions in 2020. These research results belong to Arslan, Tayfun; Bugrahan Ceylan, M.; Bas, Huseyin; Biyiklioglu, Zekeriya; Senturk, Murat. Quality Control of 4-Ethynylpyridine The article mentions the following:

In this study, phthalocyanine precursors (5 and 9) and 1,2,3-triazole-substituted metal-free and metallo phthalocyanines (9a-c) were designed and synthesized for the first time and evaluated in vitro for key mol. targets. The structures of the novel compounds were characterized via FT-IR, 1H/13C NMR, UV-Vis, and mass spectroscopy. The inhibitory activities of the compounds were tested against human carbonic anhydrase isoforms hCA I, II (cytosolic, ubiquitous isoenzymes), and IX (transmembrane, cancer-associated isoenzyme) and cholinesterases (AChE and BChE, which are associated with Alzheimer’s disease). Among the three phthalocyanines and starting compounds, 9b showed the most interesting profile as a nanomolar selective inhibitor of hCA I (Ki = 37.2 nM) and 9c showed the most effective inhibitory effect on hCA II, IX, AChE and BChE (Ki = 41.9, 27.4, 5.8 and 45.8 nM, resp.). This study is also the first example of cancer-associated isoenzyme hCA IX inhibition by phthalocyanines. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《ON/OFF Photoswitching and Thermoinduced Spin Crossover with Cooperative Luminescence in a 2D Iron(II) Coordination Polymer》 was written by Ghosh, Subrata; Kamilya, Sujit; Pramanik, Titas; Rouzieres, Mathieu; Herchel, Radovan; Mehta, Sakshi; Mondal, Abhishake. Related Products of 2510-22-7 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

A 2D coordination polymer, {[Fe(L)2(NCSe)2]·6MeOH·14H2O}n (1; L = 2,5-dipyridylethynylene-3,4-ethylenedioxythiophene), has been synthesized based on a redox active luminescence ligand. 1 possesses a 2D [4 x 4] square-grid network where the iron(II) center is in a FeN6 octahedral coordination environment. 1 displays reversible thermoinduced high-spin (HS; S = 2) to diamagnetic low-spin (LS; S = 0) ON/OFF spin-state switching with a T1/2 value of 150 K. Interestingly, optical reflectivity and photomagnetic studies at 10 K under light irradiation revealed an efficient conversion to a photoinduced metastable HS excited state from a LS ground state. Remarkably, the photoexcited HS state can be reversibly switched ON and OFF by using 625 and 850 nm light-emitting-diode lights. Intriguingly, the thermal dependence of the luminescence intensity of the maximum emission at 524 nm for 1 shows a min. at around the spin-crossover (SCO) temperature, indicating a cooperative nature between the SCO and luminescence properties. Theor. calculations confirmed the above findings. A 2D [4 x 4] square-grid iron(II) coordination polymer based on a 3,4-ethylenedioxythiophene-containing redox active luminescence ligand has been investigated. Temperature and/or light irradiation significantly alters the cooperative magnetic and optical properties, implying that the material exhibits reversible thermo- and photoinduced ON/OFF spin-state switching behavior with cooperative luminescence properties. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bennett, Troy L. R.; Wilkinson, Luke A.; Lok, Jasmine M. A.; O’Toole, Robert C. P.; Long, Nicholas J. published their research in Organometallics in 2021. The article was titled 《Synthesis, Electrochemistry, and Optical Properties of Highly Conjugated Alkynyl-Ferrocenes and -Biferrocenes》.Category: pyridine-derivatives The article contains the following contents:

Sonogashira reactions are utilized herein to react iodo-ferrocenes and -biferrocenes with terminal alkyne ligands, functionalized with both pyridine and thioanisole groups. High-yielding reactions generate both monoalkynyl and dialkynyl derivatives, the ratio of which can be altered through changes in the reaction stoichiometry. This methodol. allowed us to synthesize a large family of derivatives, comprising four sym. derivatives (3xx, where x represents a phenyl-substituted terminal alkyne) and six less-studied asym. derivatives (3xy, where x and y represent two different phenyl-substituted terminal alkynes), as well as a number of their biferrocenyl analogs (6x, 7xx, and 7xy), including the first known examples of asym. disubstituted biferrocenes. Authors examined the electrochem. behavior of all the systems in solution through the use of cyclic voltammetry and demonstrate that these highly conjugated alkynyl ligands exert delicate redox control over the central ferrocene motif. They also note that these substituents display some control over the mixed-valence character present in biferrocene monocations, with thioanisole substituents imparting almost an order of magnitude higher Kc than their pyridyl analogs, and asym. systems displaying rare characteristic properties of mixed-valence isomers. The electronic structure of these systems was further elucidated through a combination of UV/vis spectroscopy and d. functional theory calculations Their methodol. provides a facile and adaptable route toward the isolation of a number of novel ferrocene and biferrocene derivatives From their perspective, the asym. nature of these systems, along with the delicate and predictable redox control that these ligands exert on the central ferrocene unit(s), could lead to applications in mol. electronics, where these properties have previously shown promise in the fabrication of diodes and rectifiers, as well as in the synthesis of donor-π-acceptor systems. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Category: pyridine-derivatives)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem