Category: 2510-22-7

In 2022,Wu, Yaxing; Wu, Chao; Wang, Fei; Chen, Chao published an article in New Journal of Chemistry. The title of the article was 《Cu-catalyzed [2 + 2 + 1] cascade annulation of vinyl iodonium salts with elemental sulfur/selenium for the modular synthesis of thiophenes and selenophenes》.Product Details of 2510-22-7 The author mentioned the following in the article:

A [2 + 2 + 1] annulation protocol was established for the modular synthesis of 2,4-disubstituted thiophenes/selenophenes, with excellent regioselectivity. The reactions was catalyzed by copper salt with elemental sulfur and selenium serving as the chalcogen source. The mechanistic study was revealed that this process was initiated by a trisulfur radical anion using EPR. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7Product Details of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chemoselective Synthesis of 1,1-Disubstituted Vinyl Triflates from Terminal Alkynes Using TfOH in the Presence of TMSN3》 was written by Tummatorn, Jumreang; Punjajom, Kunlayanee; Rodphon, Warabhorn; Ruengsangtongkul, Sureeporn; Chaisan, Nattawadee; Lumyong, Kanyapat; Thongsornkleeb, Charnsak; Nimnual, Phongprapan; Ruchirawat, Somsak. Quality Control of 4-EthynylpyridineThis research focused onvinyl triflate regioselective chemoselective preparation; terminal alkyne regioselective chemoselective triflation triflic acid silyl azide; hydrazoic acid generated triflation toxic explosive. The article conveys some information:

1,1-Disubstituted vinyl triflates were prepared chemoselectively and regioselectively by direct hydrotriflation of terminal alkynes with TfOH and TMSN3 in DCM at room temperature; internal alkynes did not react under these conditions. Aryl alkynes with both terminal and internal alkyne moieties reacted only at their terminal alkyne moieties. Hydrazoic acid generated in situ in the triflation reaction is toxic and potentially explosive; the reactions should be performed in a well-ventilated fume hood.4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Mandler, Michael D.; Degnan, Andrew P.; Zhang, Shasha; Aulakh, Darpandeep; Georges, Ketleine; Sandhu, Bhupinder; Sarjeant, Amy; Zhu, Yeheng; Traeger, Sarah C.; Cheng, Peter T.; Ellsworth, Bruce A.; Regueiro-Ren, Alicia published an article in Organic Letters. The title of the article was 《Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry》.Safety of 4-Ethynylpyridine The author mentioned the following in the article:

Owing to their participation in Click reactions, bifunctional azides are valuable intermediates in the preparation of medicines and biochem. tool compounds Despite the privileged nature of pyridines among pharmaceutical scaffolds, reports of the synthesis and characterization of azidopyridines bearing a halogen substituent for further elaboration are almost completely unknown in the literature. As azidopyridines carry nearly equal numbers of nitrogen and carbon atoms, we hypothesized that safety concerns limited the application of these useful bifunctional building blocks in medicinal and biol. chem. To address this concern, we prepared and characterized nine azidopyridines bearing a single fluorine, chlorine, or bromine atom. All were examined by differential scanning calorimetry (DSC), in which they demonstrated exotherms of 228-326 kJ/mol and onset temperatures between 119 and 135°C. Selected azidopyridines were advanced to mech. stress testing, in which impact sensitivity was noted for one regioisomer of C5H3FN4. The utility of these versatile intermediates was demonstrated through their use in a variety of Click reactions and the diversification of the halogen handles.4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Theeramunkong, Sewan; Maicheen, Chirattikan; Krongsil, Rinnara; Chaichanasap, Waritsara; Asasutjarit, Rathapon; Vajragupta, Opa published an article in 2022. The article was titled 《Synthesis and in vitro biological evaluation of (iso)quinoline-1,2,3-triazole derivatives as anticancer agents》, and you may find the article in Chemical Papers.Electric Literature of C7H5N The information in the text is summarized as follows:

Two series of triazole derivatives I [Ar = 1-naphthyl, pyridin-3-yl, isoquinolin-4-yl, etc.; R = 2-methoxyphenyl, 4-tert-butylphenyl, 2-cyanophenyl, etc.] were designed and synthesized as potential anticancer agents. A series of eighteen novel 1,2,3-triazole derivatives I were synthesized through copper catalyzed click reaction. The compounds were evaluated for their cytotoxicity activity against HepG2, HeLa cell and HEK293 cell lines using MTT assay. The results showed that compounds [Ar = 4-isoquinolyl; R = 2-methoxyphenyl, 3-cyanophenyl] were the most potent compounds against HepG2 cell with IC50 values 9.6 and 13.3μM, resp. Addnl., the compounds I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl, 3-cyanophenyl] were the most potent compounds against HeLa cell with IC50 values 5.7 and 5.8μM, resp. The results of tubulin polymerization assay demonstrated that lead compound I [Ar = 4-isoquinolyl; R = tert-butyl] and compound I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] could inhibit in vitro tubulin polymerization In addition, a mechanism study displayed that I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] blocked cell cycle arrest at G2/M phase. Furthermore, a mol. docking study demonstrated that I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] could bind to the colchicine site of tubulin and form hydrogen bonds in the active site of β-tubulin. In summary, this study recommended a promising isoquinoline-triazole scaffold for further development as more efficient microtubule polymerization inhibitors in the field of cancer treatment.4-Ethynylpyridine(cas: 2510-22-7Electric Literature of C7H5N) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Arbour, Christine A.; Imperiali, Barbara published an article in Organic Letters. The title of the article was 《Backbone-anchoring, solid-phase synthesis strategy to access a library of peptidouridine-containing small molecules》.HPLC of Formula: 2510-22-7 The author mentioned the following in the article:

Nucleoside diphosphate sugar (NDP-sugar) substrates provide the inspiration for nucleoside analog inhibitor scaffolds. By employing solid-phase synthesis, we provide a method to access a library of peptidouridine inhibitors with both minimal compound handling and purification steps. Specifically, this strategy is exemplified by generating uridine diphosphate sugar (UDP-sugar) mimics, which allow for compound elaboration by altering the dipeptide composition, the N-terminal linkage, and a pendant aryl group. To exemplify the versatility, 41 unique nucleoside analogs are presented. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7HPLC of Formula: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Xing, Hao; Yu, Ying; Liu, Junkai; Qin, Peng; Lam, Jacky Wing Yip; Shi, Bingbing; Xie, Guohua; Tang, Ben Zhong published an article in Advanced Optical Materials. The title of the article was 《A Discrete Platinum(II) Metallacycle Harvesting Triplet Excitons for Solution-Processed Deep-Red Organic Light-Emitting Diodes》.Safety of 4-Ethynylpyridine The author mentioned the following in the article:

Platinum(II) coordination-driven architectures have exhibited unique features in fabricating functional supramol. materials. By introducing luminescent moieties into the ligand structure, various light-emitting metallacycles and metallacages have been facilely prepared, presenting specific applications in chem. sensing, light-harvesting, and bio-imaging. Except for building up the metal-ligand bonds, the platinum(II) center should also benefit the ultimate luminescence due to its unique photophys. traits. Here, a platinum(II) metallacycle with deep-red emission for solution-processed organic light-emitting diodes is reported. This metallacycle is assembled by mixing a 180° di-Pt(II) acceptor with a pyridyl-decorated ligand functionalized by a deep-red fluorescent emitter. Notably, the platinum(II) acceptor permits the efficient intramol. transfer of all elec. generated singlet and triplet excitons from itself to the fluorescent moiety, which dramatically enhances the external quantum efficiency of the device compared with the one consisting of the sole ligand. The present results reveal the function of platinum(II) metallacycles in light-emitting devices, a finding which should apply to other coordination-driven architectures with versatile properties. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-EthynylpyridineIn 2022 ,《Study on “”Click”” assembly of novel dual inhibitors of AChE and MAO-B from pyridoxine derivatives for the treatment of Alzheimer’s disease》 appeared in Heterocyclic Communications. The author of the article were Jia, Zhao; Wen, Huiyun; Huang, Saipeng; Luo, Yane; Gao, Juanjuan; Wang, Ruijie; Wan, Kaikai; Xue, Weiming. The article conveys some information:

This study fast synthesizes numerous functionalized pyridoxines I [R = Ph, 4-fluorophenyl, 3-aminophenyl, etc.] using click chem. and assayed in vitro as inhibitors of the acetylcholinesterase (AChE), butyrylcholinesterase, and two monoamine oxidase (MAO) isoforms, MAO-A and MAO-B. Most of the obtained compounds demonstrated good AChE and selective MAO-B inhibitory activities in the micromolar range, especially one compound, called I [R = 3-aminophenyl], exhibits excellent inhibitory performance against AChE (IC50 = 0.0816 ± 0.075μM) and MAO-B (IC50 = 0.039 ± 0.003μM). Finally, a docking study was carried out, demonstrating potential binding orientations and interactions of the compounds in terms of the AChE and MAO-B active sites. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,New Journal of Chemistry included an article by Meti, Puttavva; Nagaraju, Goli; Yang, Jung-Won; Jung, Sun Hwa; Gong, Young-Dae. Application In Synthesis of 4-Ethynylpyridine. The article was titled 《Synthesis of dipyrrolopyrazine-based sensitizers with a new π-bridge end-capped donor-acceptor framework for DSSCs: a combined experimental and theoretical investigation》. The information in the text is summarized as follows:

The strategy of developing organic dyes with exceptional optical, thermal, and stable photovoltaic properties has attracted substantial attention in the replacement of high-cost traditional dyes in DSSCs. Herein, we synthesized four dyes with a D-π-A configuration in order to study the variation produced in the optical, thermal, redox and photovoltaic properties by substitution of different donors and acceptors in the dipyrrolopyrazine (DPP) system. These push-pull systems are based on a pyrrolopyrazine spacer, end-capped with donors (N,N-dimethylamine, and thiophene) and acceptors (pyridine, -COOH, and -CN). The multidisciplinary study concerning the optical, thermal, redox, and photovoltaic characterization of the dyes reveals that compound 3a exhibits the best overall conversion efficiency as a sensitizer in TiO2 dye sensitized solar cells. The theor. calculations together with exptl. data allow us to quantify the charge transfer character of dyes. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Resolution of minor size differences in a family of heteroleptic coordination cages by trapped ion mobility ESI-MS》 were Ebbert, Kristina E.; Schneider, Laura; Platzek, Andre; Drechsler, Christoph; Chen, Bin; Rudolf, Robin; Clever, Guido H.. And the article was published in Dalton Transactions in 2019. Related Products of 2510-22-7 The author mentioned the following in the article:

A complex system of heteroleptic coordination cages based on the combination of 4 bis-monodentate ligands whose backbones only slightly differ in shape and length is reported. Cis-[Pd2L2L’2] assemblies cleanly form after addition of PdII cations to a 1:1 mixture of 2 shape-complementary ligands, each. When 3 or even all 4 ligands are used in combination, the unambiguous discrimination of all individual species in the product mixture becomes difficult by conventional NMR spectroscopic and mass spectrometric methods. Due to steric constraints, the system is restricted to the formation of 10 different coordination cages in total, 2 of which are isomeric. High-resolution trapped ion mobility mass spectrometry (TIMS) allows the clear differentiation of all 10 species. Observed size trends could be readily reproduced by the calculation of theor. values for collisional cross sections (CCS) from geometry-optimized models. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stevens, Matthew P.; Spray, Emily; Vitorica-Yrezabal, Inigo J.; Singh, Kuldip; Timmermann, Vanessa M.; Sotorrios, Lia; Macgregor, Stuart A.; Ortu, Fabrizio published an article in 2022. The article was titled 《Synthesis, characterisation and reactivity of group 2 complexes with a thiopyridyl scorpionate ligand》, and you may find the article in Dalton Transactions.Computed Properties of C7H5N The information in the text is summarized as follows:

Herein we report the reactivity of the proligand tris(2-pyridylthio)methane (HTptm) with various Alk. Earth (AE) reagents: (1) dialkylmagnesium reagents and (2) AE bis-amides (AE = Mg-Ba). Heteroleptic complexes of general formulas [Mg(Tptm)(R)] (R = Me, Bu) and [AE(Tptm)(NR2)] (AE = Mg-Ba; R = SiMe3) were targeted from the reaction of HTptm with R2Mg or [AE(NR2)2]2. Reaction of the proligand with dialkylmagnesium reagents led to formation of [{Mg(κ3C,N,N-CBu{S-C5H4N}2)(μ-S-C5H4N)}2] (1) and [{Mg(κ3C,N,N-CMe{S-C5H4N}2)(μ-OSiMe3)}2] (2) resp., as a result of a novel transfer of an alkyl group onto the methanide carbon with concomitant C-S bond cleavage. However, reactivity of bis-amide precursors for Mg and Ca did afford the target species [AE(Tptm)(NR2)] (3-AE; AE = Mg-Ca), although these proved susceptible to ligand degradation processes. DFT calculations show that alkyl transfer in the putative [Mg(Tptm)(Bu)] (1m’) system and amide transfer in 3-Ca is a facile process that induces C-S bond cleavage in the Tptm ligand. The complexes 3-Mg and 3-Ca were also tested as catalysts for the hydrophosphination of selected alkenes and alkynes, including the first example of mono-hydrophosphination of 4-ethynylpyridine which was achieved with high conversions and excellent regio- and stereochem. control. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem