Category: 2510-22-7

《Self-Assembled Perylene Bisimide-Cored Trigonal Prism as an Electron-Deficient Host for C60 and C70 Driven by “”Like Dissolves Like””》 was written by Chang, Xingmao; Lin, Simin; Wang, Gang; Shang, Congdi; Wang, Zhaolong; Liu, Kaiqiang; Fang, Yu; Stang, Peter J.. Recommanded Product: 4-Ethynylpyridine And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Poor processability of fullerenes is a major remaining drawback for them to be studied monomolecularly and to find real-life applications. One of the strategies to tackle this problem is to encapsulate them within a host, which is however quite often, accompanied by significant alteration of their phys./chem. properties as encountered in chem. modification. To minimize the effect, an electron-deficient entities-based, dissolvable, and fluorescence active supramol. host was designed and constructed via coordination-driven self-assembly of o-tetrapyridyl perylene bisimide (PBI) with cis-(PEt3)2Pt(OTf)2. The trigonal prism 1 possesses a trigonal-prismatic inner cavity with 14.7 Å as the diameter of its inscribed circle. Host-guest chem. investigations revealed that both C60 and C70 could be quant. encapsulated by the host in a 1:1 ratio. Further studies demonstrated that the produced host-guest complex 1⊃C70 is significantly more stable than 1⊃C60, allowing complete transformation of the latter to the former and separation of C70 from its mixture with C60. The fullerenes in the inclusion state could rotate freely within the cavity. Electrochem. and spectroscopy studies disclosed that the encapsulation of the guests shows little effect upon the reduction of the host and its fluorescence properties. Thus, “”like dissolves like”” is believed to be the main driving force for the formation of the host-guest complexes. Moreover, the host and host-guest complexes can be fabricated into monomol. membranes using the conventional Langmuir-Blodgett technique. We propose that these unique host-guest complexes could be used as model ensembles for further studies of the phys./chem. properties of fullerenes in both single mol. and 2D membrane states. In addition, their reversible four-electron reduction property may allow them to find applications in photo/electrocatalysis, organic electronics, etc. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Shuyuan; Han, Jianlei; Jin, Xue; Ye, Qiang; Zhou, Jin; Duan, Pengfei; Liu, Minghua published an article in 2021. The article was titled 《Halogen Bonded Chiral Emitters: Generation of Chiral Fractal Architecture with Amplified Circularly Polarized Luminescence》, and you may find the article in Angewandte Chemie, International Edition.Synthetic Route of C7H5N The information in the text is summarized as follows:

Self-assembled chiroptical materials have attracted considerable attention due to their great applications in wide fields. During the chiral self-assembly, it remains unknown how achiral mols. can affect the assembly process and their final chiroptical performance. Herein, the authors report an achiral mol. directed chiral self-assembly via halogen bonds, exhibiting not only an unprecedented chiral fractal architecture but also significantly amplified circularly polarized luminescence (CPL). Two axially chiral emitters with halogen bond sites co-assemble with an achiral 1,4-diiodotetrafluorobenzene (F4DIB) and well-ordered chiral fractal structures with asymmetry amplification are obtained. The enhancement of the dissymmetry factors of the assemblies was ≤0.051 and ≤0.011, which was ∼100 folds than those of the corresponding mols. Both the design of the chiral emitter and the highly directional halogen bond played an important role in hierarchically chirality transfer from chiral emitters to the micrometer scale chiral fractal morphol. and amplified dissymmetry factors. The authors hope that this strategy can give a further insight into the fabrication of structurally unique featured highly efficient chiroptical materials. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Synthetic Route of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Synthetic Route of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Peng-Fei; Yu, Jiao; Guo, Kai-Xin; Jiang, Sheng-Peng; Chen, Ji-Jun; Gu, Qiang-Shuai; Liu, Ji-Ren; Hong, Xin; Li, Zhong-Liang; Liu, Xin-Yuan published an article in 2022. The article was titled 《Design of Hemilabile N,N,N-Ligands in Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Benzyl/Propargyl Halides with Alkenylboronate Esters》, and you may find the article in Journal of the American Chemical Society.Application of 2510-22-7 The information in the text is summarized as follows:

The enantioconvergent radical C(sp3)-C(sp2) cross-coupling of alkyl halides with alkenylboronate esters is an appealing tool in the assembly of synthetically valuable enantioenriched alkenes owing to the ready availability, low toxicity and air/moisture stability of alkenylboronate esters. A copper/chiral N,N,N-ligand catalytic system for the enantioconvergent cross-coupling of benzyl/propargyl halides with alkenylboronate esters (>80 examples) with good functional group tolerance was reported. The key to the success was the rational design of hemilabile N,N,N-ligands by mounting steric hindrance at the ortho position of one coordinating quinoline ring. Thus, the newly designed ligand not only promote the radical cross-coupling process in the tridentate form but also delivered enantiocontrol over highly reactive alkyl radicals in the bidentate form. Facile follow-up transformations highlight its potential utility in the synthesis of various enantioenriched building blocks as well as in the late-stage functionalization for drug discovery.4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Gottwald, Dominique; Geidel, Christian; Rueffer, Tobias; Schaarschmidt, Dieter; Lang, Heinrich published an article in Journal of Organometallic Chemistry. The title of the article was 《Heterodi-, -tri- and -tetrametallic Transition-Metal-Complexes》.Safety of 4-Ethynylpyridine The author mentioned the following in the article:

Complexes trans-[Pt(CCMc)2(PBu3)2] (Mc = Fc = Fe(n5-C5H4)(n5-C5H5) (3), [1,2] Mc = Rc = Ru(n5-C5H4)(n5-C5H5) (4)) were synthesized by treatment of cis-[PtCl2(PBu3)2] with McCCH (Mc = Fc (1), Rc (2)). The synthesis of trans-[Pt(PR3)2(CCFc)(CCR’)] (R = Bu: R’ = H (7a), R’ = PPh2 (7b), R’ = Rc (7c); R = Ph: R’ = 4-C5H4N (8a), R’ = C6H4-4-CN (8b), R’ = 2,2′-bipyridin-5-yl (8c), R’ = C6H4-4-CCH (8d)) was realized by the reaction of trans-[PtCl(PR3)2(CCFc)] (R = Bu (5), R = Ph (6)) with alkynes HCCR’. Treatment of 8a with [RuCl2(cymene)]2 (cymene = η6-1-Me-4-iPr-C6H4) or [Rh(η5-C5Me5)Cl2]2 and of 8c with [Mo(CO)4(2,5-norbornadiene)] or [Mn(CO)5Br] led to heterotrimetallic trans-[Pt(PPh3)2(CCFc)(CCR’-{M})] (R’ = 4-C5H4N: {M} = Ru(η6-cymene)Cl2 (10a), = Rh(η5-C5Me5)Cl2 (10b); R’ = 2,2′-bipyridin-5-yl: {M} = Mo(CO)4 (11a), = Mn(CO)3Br (11b)). When 8b,c were reacted with [{[Ti](μ-σ,π-CCSiMe3)2}Cu(MeCN)][PF6] ([Ti] = Ti(η5-C5H4SiMe3)2) then heterotetrametallic trans-[Pt(PPh3)2(CCFc)(CCR’-{M})][PF6] {M} = [Ti](μ-σ,π-CCSiMe3)2Cu: R’ = 2,2′-bipyridin-5-yl (11c), R’ = -C6H4-4-CN (11d) were produced. Compounds 3, 4 and 7c were characterized by single-crystal X-ray diffraction studies establishing the trans arrangement at Pt. The electrochem. behavior of all compounds was investigated by CV showing reversible redox events for Fc in 3, 7a,c, 8a-d, 10a,b, 11b,c in the range of E°1′ = -120 – -85 mV, while M feature irreversible redox processes between 745 and 1230 mV. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 2510-22-7In 2019 ,《Sequentially Pd/Cu-Catalyzed Alkynylation-Oxidation Synthesis of 1,2-Diketones and Consecutive One-Pot Generation of Quinoxalines》 was published in European Journal of Organic Chemistry. The article was written by Niesobski, Patrik; Martinez, Ivette Santana; Kustosz, Sebastian; Mueller, Thomas J. J.. The article contains the following contents:

We report a simple and efficient one-pot synthesis of 1,2-diketones by concatenation of two Pd/Cu-catalyzed processes: Pd0/CuI-catalyzed Sonogashira coupling of terminal alkynes with aryl (pseudo)halides furnishes internal alkynes, which are directly transformed by PdII/CuII-catalyzed Wacker-type oxidation with DMSO and oxygen as dual oxidants to furnish 1,2-diketones. With this efficient, catalyst economical process, various aryl iodides and triflates are efficiently transformed in high yields into sym. and unsym. substituted 1,2-diketones with various functional groups. This process can be readily extended to a consecutive one-pot synthesis of quinoxalines in a diversity-oriented fashion. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-EthynylpyridineIn 2019 ,《Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Leenders, Ruben; Zijlmans, Remco; van Bree, Bart; van de Sande, Marc; Trivarelli, Federica; Damen, Eddy; Wegert, Anita; Mueller, Daniel; Ehlert, Jan Erik; Feger, Daniel; Heidemann-Dinger, Carolin; Kubbutat, Michael; Schaechtele, Christoph; Lenstra, Danny C.; Mecinovic, Jasmin; Mueller, Gerhard. The article conveys some information:

Detailed structure activity relationship of two series of quinazoline EHMT1/EHMT2 inhibitor compounds I [R = COOH, CONH2, (5-prop-2-ynylpyrrolidin-2-one)-3-yl etc.] and II [R1 = OMe, F, OCF3 ; R2 = aminopropynyl,(5-prop-2-ynylpyrrolidin-2-one)-3-yl etc.] were elaborated. New and active alternatives were presented for the ubiquitous substitution patterns found in literature for the linker to the lysine mimicking region and the lysine mimic itself. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Name: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rapid One-Pot Sequential Cyclization, Palladium Precatalyst Mediated Coupling Reactions of 6-Bromo-2-Chloroquinoline-3-Carboxaldehyde in Aqueous Medium》 was written by Thiyagamurthy, Pandurangan; Nawaz Khan, Fazlur-Rahman. Recommanded Product: 2510-22-7This research focused onxanthenedione quinolinyl preparation; bromo chloroquinoline carboxaldehyde Suzuki Sonogashira Stille coupling palladium catalyst. The article conveys some information:

Xanthene-1,8(2H)-diones I (R = Ph, 2-(pyridin-4-yl)ethynyl, ethenyl, etc.), were obtained from 6-bromo-2-chloro quinoline-3-carboxaldehyde, in water reflux and subsequently underwent Suzuki-Miyaura cross/Sonogashira/Stille coupling utilizing second generation XPhos Palladium preformed catalyst. Low catalyst loading, ambient temperature and wide scope of boronic acids, enantioselectivity are the advantages. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands》 was written by Meier-Menches, Samuel M.; Aikman, Brech; Dollerer, Daniel; Klooster, Wim T.; Coles, Simon J.; Santi, Nicolo; Luk, Louis; Casini, Angela; Bonsignore, Riccardo. Recommanded Product: 2510-22-7 And the article was included in Journal of Inorganic Biochemistry in 2020. The article conveys some information:

Exptl. organometallic gold(I) compounds hold promise for anticancer therapy. This study reports the synthesis of two novel families of gold(I) complexes, including N1-substituted bis-N-heterocyclic carbene (NHC) complexes of general formula [Au(N1-TBM)2]BF4 (N1-TBM = N1-substituted 9-methyltheobromin-8-ylidene) and mixed gold(I) NHC-alkynyl complexes, [Au(N1-TBM)alkynyl]. The compounds were fully characterized for their structure and stability in aqueous environment and in the presence of N-acetyl cysteine by NMR spectroscopy. The structures of bis(1-ethyl-3,7,9-trimethylxanthin-8-ylidene)gold(I), (4-ethynylpyridine)(1,9-dimethyltheobromine-8-ylidene)gold(I) and of (2,8-Diethyl-10-(4-ethynylphenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine)(1,3,7,9-tetramethylxanthin-8-ylidene)gold(I) were also confirmed by X-ray diffraction anal. The compounds were studied for their properties as DNA G-quadruplex (G4 s) stabilizers by fluorescence resonance energy transfer (FRET) DNA melting. Only the cationic [Au(N1-TBM)2]BF4 family showed moderate G4 stabilization properties with respect to the previously reported benchmark compound [Au(9-methylcaffein-8-ylidene)2]+ (AuTMX2). However, the compounds also showed marked selectivity for binding to G4 structures with respect to duplex DNA in competition experiments For selected complexes, the interactions with G4 s were also confirmed by CD (CD) studies. Furthermore, the gold(I) complexes were assessed for their antiproliferative effects in human cancer cells in vitro, displaying moderate activity. Of note, among the mixed gold(I) NHC-alkynyl compounds, one features a fluorescent boron-dipyrromethene (BODIPY) moiety which allowed determining its uptake into the cytoplasm of cancer cells by fluorescence microscopy. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Carbazole-Based Tetrapodal Anchor Groups for Gold Surfaces: Synthesis and Conductance Properties》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to O’Driscoll, Luke J.; Wang, Xintai; Jay, Michael; Batsanov, Andrei S.; Sadeghi, Hatef; Lambert, Colin J.; Robinson, Benjamin J.; Bryce, Martin R.. Application of 2510-22-7 The article mentions the following:

As the field of mol.-scale electronics matures and the prospect of devices incorporating mol. wires becomes more feasible, it is necessary to progress from the simple anchor groups used in fundamental conductance studies to more elaborate anchors designed with device stability in mind. This study presents oligo(phenylene-ethynylene) wires with one tetrapodal anchor and a Ph or pyridyl head group. The new anchors are designed to bind strongly to Au surfaces without disrupting the conductance pathway of the wires. Conductive probe at. force microscopy (cAFM) was used to determine the conductance of self-assembled monolayers (SAMs) of the wires in Au-SAM-Pt and Au-SAM-graphene junctions, from which the conductance per mol. was derived. For tolane-type wires, mean conductances per mol. of up to 10-4.37 G0 (Pt) and 10-3.78 G0 (graphene) were measured, despite limited electronic coupling to the Au electrode, demonstrating the potential of this approach. Computational studies of the surface binding geometry and transport properties rationalize and support the exptl. results. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes》 was written by Lv, Yunhe; Pu, Weiya; Wang, Xiaoxing. Category: pyridine-derivatives And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The copper-catalyzed highly regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes with α-chloroacetamides and dialkyl 2-fluoromalonate or 2-fluoro-N,N-dialkyl-3-oxobutanamide without an external ligand was realized. With this novel methodol., (E)-β-monofluoroalkyl-β,γ-unsaturated amides containing quaternary C-F centers I [R = CH2OMe, 3-thienyl, Ph, etc.] could be easily constructed in good to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Category: pyridine-derivatives)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem