Category: 2510-22-7

Gil-Martinez, Jon; Macias, Iratxe; Unione, Luca; Bernardo-Seisdedos, Ganeko; Lopitz-Otsoa, Fernando; Fernandez-Ramos, David; Lain, Ana; Sanz-Parra, Arantza; Mato, Jose M.; Millet, Oscar published an article in 2021. The article was titled 《Therapeutic targeting of fumaryl acetoacetate hydrolase in hereditary tyrosinemia type I》, and you may find the article in International Journal of Molecular Sciences.Electric Literature of C7H5N The information in the text is summarized as follows:

Fumarylacetoacetate hydrolase (FAH) is the fifth enzyme in the tyrosine catabolism pathway. A deficiency in human FAH leads to hereditary tyrosinemia type I (HT1), an autosomal recessive disorder that results in the accumulation of toxic metabolites such as succinylacetone, maleylacetoacetate, and fumarylacetoacetate in the liver and kidney, among other tissues. The disease is severe and, when untreated, it can lead to death. A low tyrosine diet combined with the herbicidal nitisinone constitutes the only available therapy, but this treatment is not devoid of secondary effects and long-term complications. In this study, we targeted FAH for the first-time to discover new chem. modulators that act as pharmacol. chaperones, directly associating with this enzyme. After screening several thousand compounds and subsequent chem. redesign, we found a set of reversible inhibitors that associate with FAH close to the active site and stabilize the (active) dimeric species, as demonstrated by NMR spectroscopy. Importantly, the inhibitors are also able to partially restore the normal phenotype in a newly developed cellular model of HT1. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Electric Literature of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-EthynylpyridineIn 2022 ,《Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype》 appeared in International Journal of Molecular Sciences. The author of the article were Chalupnik, Paulina; Vialko, Alina; Pickering, Darryl S.; Hinkkanen, Markus; Donbosco, Stephanie; Moeller, Thor C.; Jensen, Anders A.; Nielsen, Birgitte; Bay, Yasmin; Kristensen, Anders S.; Johansen, Tommy N.; Latka, Kamil; Bajda, Marek; Szymanska, Ewa. The article conveys some information:

In search of selective ligands for the GluK3 kainate receptor subtype, a series of I [R = 3-Me Ph, 4-Me Ph, 4-Et Ph, etc] analogs was synthesized and pharmacol. characterized at selected recombinant ionotropic glutamate receptors. Among them, compound I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] was found to be a competitive GluK3 antagonist with submicromolar affinity and unprecedented high binding selectivity, showing a 400-fold preference for GluK3 over other homomeric receptors GluK1, GluK2, GluK5 and GluA2. Furthermore, in functional assays performed for selected metabotropic glutamate receptor subtypes, I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] did not show agonist or antagonist activity. The mol. determinants underlying the observed affinity profile of I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] were analyzed using mol. docking and mol. dynamics simulations performed for individual GluK1 and GluK3 ligand-binding domains.4-Ethynylpyridine(cas: 2510-22-7Name: 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Sang, Zitai; Lu, Yongping; Zhou, Yuanzheng; Ju, Yuan; An, Qi; Shen, Silan; Shi, Jianyou; He, Jun; Yang, Tao; Luo, Youfu. Related Products of 2510-22-7. The article was titled 《Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract》. The information in the text is summarized as follows:

By coupling in situ [2+3] Huisgen cycloaddition with an in vitro transcription/translation luminescence assay in a crude ribosomal extract, a robust and accurate high-throughput platform was successfully developed and applied for efficient identification of novel structural types of ribosomal inhibitors with antimicrobial activity against drug-resistant bacteria. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Simin; Chang, Xingmao; Wang, Zhaolong; Zhang, Jing; Ding, Nannan; Xu, Wenjun; Liu, Ke; Liu, Zhongshan; Fang, Yu published an article in 2021. The article was titled 《High-Performance NMHC Detection Enabled by a Perylene Bisimide-Cored Metallacycle Complex-Based Fluorescent Film Sensor》, and you may find the article in Analytical Chemistry (Washington, DC, United States).Application In Synthesis of 4-Ethynylpyridine The information in the text is summarized as follows:

Non-methane hydrocarbons (NMHCs) can serve as precursors of ozone and photochem. smog, and hence their highly efficient detection is of great importance for air quality monitoring. Here, we synthesized a new fluorescent perylene bisimide (PBI)-cored metallacycle complex through coordination-driven self-assembly and used it for the production of a fluorescent film sensor. The unique rectangular structure of the developed fluorophore endows the sensor with enhanced sensing performance and discriminability to n-alkanes (C5-10). Specifically, the exptl. detection limits for n-pentane, n-hexane, and n-decane are 39, 7, and 1.4 mg/m3, resp., and the corresponding linear ranges are from 39 to 2546, 7 to 1745, and 1.4 to 85 mg/m3, resp. Moreover, the sensing is fully reversible. In tandem with a gas chromatog. separation system, the film sensor showed comparable detection ability for the n-alkanes with a com. flame ionization detector (FID), while the film sensor needs no hydrogen; it occupies a much smaller size (30 x 30 x 44 mm3) and consumes less energy (0.215 W). Further studies demonstrated that the developed sensor can be used for on-site and real-time quantification of NHMCs, laying the foundation for developing into a portable detector. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Teng, Kun-Xu; Niu, Li-Ya; Li, Jie; Jia, Lu; Yang, Qing-Zheng. Safety of 4-Ethynylpyridine. The article was titled 《An unexpected coupling-reduction tandem reaction for the synthesis of alkenyl-substituted BODIPYs》. The information in the text is summarized as follows:

We report an unexpected coupling-reduction tandem reaction as a general and efficient one-pot synthesis of alkenyl-substituted boron dipyrromethene (BODIPY) from chlorinated-BODIPY and alkyne. This unique synthesis combined the Sonogashira coupling reaction and reduction reaction without adding an addnl. reagent, which shows higher yields, broader substrate scope and faster reaction rate compared with the conventional methods of the Knoevenagel reaction and Heck coupling reaction. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Copper-catalysed three-component carboiodination of arynes: expeditious synthesis of o-alkynyl aryl iodides》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Cao, Wenxuan; Niu, Sheng-Li; Shuai, Li; Xiao, Qing. Related Products of 2510-22-7 The article mentions the following:

A copper-catalyzed three-component iodoalkynylation reaction of arynes for the expeditious and versatile synthesis of o-alkynyl aryl iodides was developed. Mechanism research shows that the reaction goes through two steps enabled by copper catalysis: the formation of 1-iodo-2-arylacetylene and the insertion of the aryne into a C(sp)-I bond.4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fluorine-substituted tetracationic ABAB-phthalocyanines for efficient photodynamic inactivation of Gram-positive and Gram-negative bacteria》 was written by Revuelta-Maza, Miguel A.; Gonzalez-Jimenez, Patricia; Hally, Cormac; Agut, Montserrat; Nonell, Santi; de la Torre, Gema; Torres, Tomas. Recommanded Product: 4-EthynylpyridineThis research focused onzinc fluorine substituted phthalocyanine complex preparation fluorescence; antibacterial activity photodynamic therapy zinc phthalocyanine; Amphiphile; Bacteria; Cationic; Photodynamic inactivation; Phthalocyanine. The article conveys some information:

Herein, the authors report the synthesis and characterization of new amphiphilic phthalocyanines (Pcs), the study of their singlet oxygen generation capabilities, and biol. assays to determine their potential as photosensitizers for photodynamic inactivation of bacteria. In particular, Pcs with an ABAB geometry (A and B refer to differently substituted isoindole constituents) have been synthesized. These mols. are endowed with bulky bis(trifluoromethylphenyl) groups in two facing isoindoles, which hinder aggregation and favor singlet oxygen generation, and pyridinium or alkylammonium moieties in the other two isoindoles. In particular, two water-soluble Pc derivatives (PS-1 and PS-2) proved to be efficient in the photoinactivation of S. aureus and E. coli, selected as models of Gram-pos. and Gram-neg. bacteria. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Peng, Sasa; Wang, Huaxin; Ding, Haichang; Fan, Congbin; Liu, Gang; Pu, Shouzhi published an article in Journal of Photochemistry and Photobiology, A: Chemistry. The title of the article was 《A high selective chemosensor for detection of Al3+ based on diarylethene with a hydrazide unit》.Recommanded Product: 2510-22-7 The author mentioned the following in the article:

Al3+ plays an indispensable role in different physiol. processes. However, excess Al3+ is destructive to health. Here, a diarylethene-based fluorescent sensor (1O) was synthesized by attaching a hydrazide group to diarylethene moiety through Schiff base structure. In acetonitrile, 1O displayed excellent selectivity and sensitivity to Al3+. The fluorescence intensity increased by 70-fold and accompanied by the color of the solution changed from dark to blue with the addition of Al3+. Further, the potential response mechanism of 1O toward Al3+ was proposed and verified by 1H NMR titrations and mass spectrometry anal., the stoichiometric ratios of the sensor with Al3+ appeared to be 1:1 with the detection limit of 0.073 μM. In addition, 1O has been successfully applied to the detection of Al3+ in real water samples, and it also has successfully designed as mol. logic circuit and test strips. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 2510-22-7In 2019 ,《Copper-catalyzed aminothiolation of terminal alkynes with tunable regioselectivity》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Kuang, Jinqiang; Xia, Yuanzhi; Yang, An; Zhang, Heng; Su, Chenliang; Lee, Daesung. The article contains the following contents:

A simple, mild, and efficient copper(I)-catalyzed aminothiolation of terminal alkynes R1CCH (R1 = HOCH2CH2, Me3Si, cyclohexen-1-yl, Ph, pyridin-2-yl, etc.) with 5-R2-substituted 2-mercaptobenzimidazoles (R2 = H, Me, MeO, O2N) gave both 2- and 3-substituted thiazolo[3,2-a]benzimidazoles I, where complementary regioselectivities could be achieved by using sterically different phenanthroline-based ligands, such as 1,10-phenanthroline and 2,9-diisopropyl-1,10-phenanthroline. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Larpent, Patrick; Jouaiti, Abdelaziz; Kyritsakas, Nathalie; Hosseini, Mir Wais. COA of Formula: C7H5N. The article was titled 《Molecular tectonics: from a rigid achiral organic tecton to 3D chiral Co and Fe coordination networks》. The information in the text is summarized as follows:

An achiral organic tecton bearing four coordinating sites of the pyridyl type gives iso-structural 3D helical coordination polymers when combined with Co(SCN)2 and Fe(SCN)2 achiral neutral complexes. Their formation occurs during the self-assembly process in the solid state, which leads to crystals composed of homochiral coordination polymers. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7COA of Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem