Category: 2510-23-8

Reference of 2510-23-8 ,Some common heterocyclic compound, 2510-23-8, molecular formula is C7H5N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of D-l 3-ethyne pyridine (8.0 g, 77.6 mmol) in THF (ISOmL) at -78 C, n-BuLi (1,6 M in hexanes, 54 mL, 85,3 mmol) was added dropwise (keeping the reaction temperature below -60 C), It was stirred at this temperature for another 2 hrs and warmed up to OC. It was cooled to -30 C again and a fresh chopped dry ice was added. It was stirred and allowed to warm up to 0 C and 20 mL 4.ON NaOH was added. Organic layer was separated, Aqueous layer was acidified to ph <1, Solid was filtered to yield the final product. Yield: 6.0 g In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2510-23-8, 3-Ethynylpyridine, other downstream synthetic routes, hurry up and to see. Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2008/14311; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2510-23-8 ,Some common heterocyclic compound, 2510-23-8, molecular formula is C7H5N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of D-l 3-ethyne pyridine (8.0 g, 77.6 mmol) in THF (ISOmL) at -78 C, n-BuLi (1,6 M in hexanes, 54 mL, 85,3 mmol) was added dropwise (keeping the reaction temperature below -60 C), It was stirred at this temperature for another 2 hrs and warmed up to OC. It was cooled to -30 C again and a fresh chopped dry ice was added. It was stirred and allowed to warm up to 0 C and 20 mL 4.ON NaOH was added. Organic layer was separated, Aqueous layer was acidified to ph <1, Solid was filtered to yield the final product. Yield: 6.0 g In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2510-23-8, 3-Ethynylpyridine, other downstream synthetic routes, hurry up and to see. Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2008/14311; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2510-23-8, name is 3-Ethynylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H5N

General procedure: The terminal alkyne (1.0 mmol) was added to a mixtureof HSi(OEt)2Me (5.0 mmol) and KOtBu (1.5 mmol) in a10 mL Schlenk tube with a magnetic stirrer. The Schlenktube was evacuated and back-filled with CO2 for 3 times.After a CO2 ballon was connected, the reactor was moved toa water bath of 40 C. After being stirred for 2 h, the reactionmixture was diluted with water (30 mL), and was extractedwith CH2Cl2 (3×10 mL). The aqueous layer was acidifiedwith aqueous HCl (6 M) and then extracted with diethylether (5×20 mL). The combined organic extracts were driedover Na2SO4 and concentrated under vacuum to give the purepropiolic acid (such as compound 3-phenylpropiolic acid(3a): 98%).

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Reference:
Article; Yu, Bo; Yang, Peng; Gao, Xiang; Yang, Zhenzhen; Zhao, Yanfei; Zhang, Hongye; Liu, Zhimin; Science China Chemistry; vol. 61; 4; (2018); p. 449 – 456;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem