Category: 25194-01-8

Adding a certain compound to certain chemical reactions, such as: 25194-01-8, 2,6-Dichloro-4-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 25194-01-8, blongs to pyridine-derivatives compound. Product Details of 25194-01-8

REFERENCE SYNTHESIS EXAMPLE 1 Synthesis of 2,6-dichloro-4-methoxypyridine used in the Synthesis example 6 To a tetrahydrofuran solution containing methanol (0.37 g, 0.0104*1.1 mol), sodium hydride (0.44 g, (ca.60% in mineral oil), 0.0104*1.05 mol) was added. Then 2,6-dichloro-4-nitropyridine (2.00 g, 0.0104 mol) was added thereto and the mixture was stirred for about 2 hours at room temperature. After it was confirmed that there was no bubbling with the addition of methanol (0.5 g), the mixture was stirred for about 1 hour. The reaction solution was partitioned between ethyl acetate and water. The obtained organic layer was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, then dried over anhydrous sodium sulfate and concentrated to obtain the end product which was almost pure. Yield: 1.63 g (88%). Solid. Melting point: 94-96 C. 1 H-NMR (60 MHz, CDCl3, delta): 3.79(3H,s), 6.70(2H,s).

The synthetic route of 25194-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US5624942; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 25194-01-8 ,Some common heterocyclic compound, 25194-01-8, molecular formula is C5H2Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step A: 4,6-dichloro-1 H-pyrrolor3,2-clpyridine: 2,6-dichloro-4-nitro-pyridine (1 1 g, 57 mmol) was dissolved in dry tetrahydrofurane (300 ml_), cooled to -78C and treated dropwise with bromo(vinyl)magnesium (1 M in THF, 200 ml_, 200 mmol). The reaction was allowed to react at this temperature for 1 hour and then allowed to warm to -20C. The reaction mixture was then quenched with 200 ml of aqueous NH4CI and the mixture obtained was partitioned in ethyl acetate. The aqueous layer was extracted 3 times with 200 ml of ethyl acetate and the combined organic layer dried over Na2S04, filtered and concentrated in vacuo. Purification by Combi flash chromatography with a column of 120g and a gradient cyclohexane:0-100% ethyl acetate, and then with a column of 40 g and a gradient dichloromethane:0-10% ethyl acetate gave the title compound as brown solid (0.150 g, 1 .4%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25194-01-8, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; BIGOT, Aurelien; HALL, Roger Graham; JEANGUENAT, Andre; LUKSCH, Torsten; RENDLER, Sebastian; WO2013/156431; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 25194-01-8, 2,6-Dichloro-4-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H2Cl2N2O2, blongs to pyridine-derivatives compound. HPLC of Formula: C5H2Cl2N2O2

(1) Synthesis of an Intermediate, 2,6-dichloro-4-methoxypyridine To a tetrahydrofuran solution containing methanol (0.37 g, 0.0104*1.1 mol), sodium hydride (0.44 g (ca. 60% in mineral oil), 0.0104*1.05 mol) was added, then 2,6-dichloro-4-nitropyridine (2.00. g, 0.0104 mol) was added thereto and the resultant solution was stirred for about 2 hours at room temperature. After it was confirmed that there was no bubbling with the addition of methanol (1.0 g, 0.0355*0.9 mol), the resultant solution was stirred for about another 1 hour. After the reaction solution was partitioned between ethyl acetate and water, the obtained organic layer was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and thereafter concentrated to obtain the substantially pure end product. Yield: 1.63 g (88%). Solid. Melting point: 94 to 96 C. 1 H-NMR (60 MHz, CDCl3, delta): 3.79(3H, s), 6.70(2H, s).

The synthetic route of 25194-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US5691277; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 25194-01-8, 2,6-Dichloro-4-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H2Cl2N2O2, blongs to pyridine-derivatives compound. HPLC of Formula: C5H2Cl2N2O2

(1) Synthesis of an Intermediate, 2,6-dichloro-4-methoxypyridine To a tetrahydrofuran solution containing methanol (0.37 g, 0.0104*1.1 mol), sodium hydride (0.44 g (ca. 60% in mineral oil), 0.0104*1.05 mol) was added, then 2,6-dichloro-4-nitropyridine (2.00. g, 0.0104 mol) was added thereto and the resultant solution was stirred for about 2 hours at room temperature. After it was confirmed that there was no bubbling with the addition of methanol (1.0 g, 0.0355*0.9 mol), the resultant solution was stirred for about another 1 hour. After the reaction solution was partitioned between ethyl acetate and water, the obtained organic layer was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and thereafter concentrated to obtain the substantially pure end product. Yield: 1.63 g (88%). Solid. Melting point: 94 to 96 C. 1 H-NMR (60 MHz, CDCl3, delta): 3.79(3H, s), 6.70(2H, s).

The synthetic route of 25194-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US5691277; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem