Category: 257937-08-9

Hydroarylation of Arenes via Reductive Radical-Polar Crossover was written by Flynn, Autumn R.;McDaniel, Kelly A.;Hughes, Meredith E.;Vogt, David B.;Jui, Nathan T.. And the article was included in Journal of the American Chemical Society in 2020.Name: tert-Butyl (3-bromopyridin-4-yl)carbamate This article mentions the following:

A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed. Using a combination of an organic photoredox catalyst and an amine reductant, this process operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers a regioselective radical cyclization event, followed by anion formation and quenching to produce a range of complex spirocyclic cyclohexadienes. This light-driven protocol functions at room temperature in a green solvent system (aqueous MeCN) without the need for precious metal-based catalysts or reagents or the generation of stoichiometric metal byproducts. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9Name: tert-Butyl (3-bromopyridin-4-yl)carbamate).

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: tert-Butyl (3-bromopyridin-4-yl)carbamate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes was written by Makida, Yusuke;Saita, Masahiro;Kuramoto, Takahiro;Ishizuka, Kentaro;Kuwano, Ryoichi. And the article was included in Angewandte Chemie, International Edition in 2016.Recommanded Product: 257937-08-9 This article mentions the following:

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η³-methallyl)₂(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9Recommanded Product: 257937-08-9).

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 257937-08-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis was written by Khandazhinskaya, Anastasia;Eletskaya, Barbara;Fateev, Ilja;Kharitonova, Maria;Konstantinova, Irina;Barai, Vladimir;Azhayev, Alex;Hyvonen, Mervi T.;Keinanen, Tuomo A.;Kochetkov, Sergey;Seley-Radtke, Katherine;Khomutov, Alex;Matyugina, Elena. And the article was included in Organic & Biomolecular Chemistry in 2021.Computed Properties of C10H13BrN2O2 This article mentions the following:

Nucleoside analogs have long served as key chemotherapeutic drugs for the treatment of viral infections and cancers. Problems associated with the development of drug resistance have led to a search for the design of nucleosides capable of bypassing point mutations in the target enzyme’s binding site. As a possible answer to this, the Seley-Radtke group developed a flexible nucleoside scaffold (fleximers), where the heterocyclic purine base is split into its two components, i.e. pyrimidine and imidazole. Herein, we present a series of new pyrazole-containing flex-bases and the corresponding fleximer analogs of 8-aza-7-deaza nucleosides. Subsequent studies found that pyrazole-containing flex-bases are substrates of purine nucleoside phosphorylase (PNP). We have compared the chem. synthesis of fleximers and enzymic approaches with both isolated enzymes and the use of E. coli cells over-producing PNP. The latter provided stereochem. pure pyrazole-containing β-D-ribo- and β-D-2′-deoxyribo-fleximers and are beneficial in terms of environmental issues, are more economical, and streamline the steps required from a chem. approach. The reaction is carried out in water, avoiding hazardous chems., and the products are isolated by ion-exchange chromatog. using water/ethanol mixtures for elution. Moreover, the target nucleosides were obtained on a multi-milligram scale with >97-99% purity, and the reactions can be easily scaled up. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9Computed Properties of C10H13BrN2O2).

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Computed Properties of C10H13BrN2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem