Category: 26820-62-2

Charushin, Valery N. published the artcileRing transformations in reactions of heterocyclic compounds with nucleophiles. Part 26. 1,3- and 1,4-Cyclo adducts as intermediates in the pyrimidine to pyridine ring transformation of 5-nitropyrimidines by α-phenylacetamidines, Formula: C9H11N3O3, the main research area is pyrimidine reaction nucleophile; acetamidine phenyl reaction pyrimidine; pyridine amino nitropyrimidine.

5-Nitropyrimidine reacts with PhCH2CR:NH (R = NH2, NMe2, NEt2) at -40° to form σ adducts at the C-2 position of the ring, but gives 2-aminopyridine derivatives I at temperatures above 0 °. Experiments with 15N-labeled PhCH2C(:NH)NH2 showed that the reaction proceeds via different reaction pathways with replacement of either the N(1)-C(2)-N(3) or N(1)-C(2) fragment of the pyrimidine ring by the C-C-N or the C-C moiety of the amidine. The role of 1,3- and 1,4-cycloadducts as possible intermediates in the ring-transformation reaction is discussed.

Journal of Organic Chemistry published new progress about Nucleophiles. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jin, Bo published the artcileSynthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)-oxazolidinone-5-methyl Ester Derivatives, Category: pyridine-derivatives, the main research area is pyridyl oxazolidone methyl ester preparation stereoselective antibacterial anthelmintic human; anthelmintic activity; antibacterial activity; molecular docking; pyridinyl-oxazolidinone derivatives; synthesis.

In this study, a series of 3-(3-pyridyl)-oxazolidone-5-Me ester derivatives I [X = O, C(O)CH2Bn, C(O)NCy, etc.; R1 = C(O)Me, C(O)Cy, S(O)2Me, etc.] was synthesized and characterized by 1H NMR, 13C NMR and LC-MS. The conducted screening antibacterial studies of the new 3-(3-pyridyl)-oxazolidone-5-Me ester derivatives I established that the Me sulfonic acid esters have broad activity spectrum toward Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis and Staphylococcus epidermidis. Among them, compound I [X = O; R1 = C(O)NCy] was the most potent activity, with an MIC of 16μg/mL against B.subtilis and could reduce the instantaneous growth rate of bacteria. Furthermore, mol. docking studies were also simulated for compound I [X = O; R1 = C(O)NCy] to predict the specific binding mode of this compound In addition, anthelmintic activity of these compounds was also evaluated against adult Indian earthworms (Pheretima posthuman). The results showed that compound I [X = O, R1 = C(O)Cy] had the best effect. These results above could provided exptl. reference for the development of novel antibacterial and anthelmintic drugs.

Molecules published new progress about Anthelmintics. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mahdhaoui, Faouzi published the artcileSNAr reactions of substituted pyridines with secondary amines in aqueous solution: Kinetic and reactivity indices in density functional theory, Product Details of C9H11N3O3, the main research area is nitropyridine cyclic amine nucleophilic aromatic substitution kinetics mechanism.

A kinetic study is reported for the reactions of 2-methoxy-3-nitropyridine 1a and 2-methoxy-5-nitropyridine 1b with three secondary amines 2a-c (morpholine, piperidine, and pyrrolidine) in aqueous solution at 20°C. The Bronsted-type plots are linear with βnuc = 0.52 and 0.55 for pyridines 1a and 1b, resp., indicating that the reaction proceeds through a SNAr mechanism in which the first step is the rate-determining step. Addnl. theor. calculations using the DFT/B3LYP method confirm that the C-2 carbon being the most electrophilic center for the both pyridines 1a and 1b. The second-order rate constants have been used to evaluate the electrophilicity parameters E of 1a and 1b according to the linear free energy relationship log k (20°C) = sN (N + E). The E parameters thus derived are compared with the electrophilic reactivities of a large variety of anisoles. The validity of these E values has been satisfactorily verified by comparison of calculated and exptl. second-order rate constants for the reactions of pyridines 1a and 1b with anion of Et benzylacetate.

International Journal of Chemical Kinetics published new progress about Atomic charge. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Product Details of C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Spencer, John published the artcileSynthesis and solid state study of pyridine- and pyrimidine-based fragment libraries, Quality Control of 26820-62-2, the main research area is preparation pyridine pyrimidine library solid state study microwave irradiation.

A library of pyridines and pyrimidines, e.g. I [X = CH, N], has been synthesized in excellent yields employing microwave and flow chem. methodologies. Work-up bottlenecks have been facilitated substantially by the use of supported reagents and many of the final compounds have been studied in the solid state by single crystal X-ray diffraction.

Tetrahedron Letters published new progress about Chemical library. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Quality Control of 26820-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Lin published the artcileDiscovery of novel dual inhibitors of VEGFR and PI3K kinases containing 2-ureidothiazole scaffold, Product Details of C9H11N3O3, the main research area is phenylureidothiazolformamide preparation VEGFR PI3K kinase inhibitory anticancer SAR activity.

A series of compounds possessing 2-(3-phenyl)ureidothiazol-4-formamide derivatives with a 2-ureidothiazole scaffold were designed and synthesized. Some compounds demonstrated inhibition of cell proliferation against both MDA-MB-231 and HepG2 cell lines using Sorafenib as the pos. control. Compounds I showed a good to moderate inhibition on VEGFR-2 and PI3Kα which was proved by further mol. docking study. This study suggests that compound I is a potential dual inhibitor of VEGFR-2 and PI3Kα and is applicable for further investigation.

Chinese Chemical Letters published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Product Details of C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hamed, Ezzat A. published the artcileNucleophilic substitutions at the pyridine ring: kinetics of the reaction of 2-chloro-3-nitro and 2-chloro-5-nitropyridines with piperidine and morpholine in methanol and benzene, Formula: C9H11N3O3, the main research area is nucleophilic substitution chloronitropyridine kinetics mechanism.

The kinetics of the reactions of 2-chloro-3-nitropyridine (ortho-like) and 5-nitro (para-like) isomer with morpholine and piperidine were studied in methanol and benzene at several amine concentrations and at 25-45°. The data show that k3-NO 2/k5-NO2 ratios are less than unity in methanol. The steric hindrance in the transition state of the 3-nitro (ortho-like) isomer retards o-substitution while the stability of p-quinonoid structure of the 5-nitro (para-like) isomer favors p-substitution. In benzene, the k3-NO2/k5-NO2 ratios are greater than unity. The hydrogen bonding formation between the ammonium hydrogen and the ortho-nitro group in the transition state of 3-nitro isomer favors the o-substitution.

International Journal of Chemical Kinetics published new progress about Activation energy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jin, Bo published the artcileSynthesis and biological evaluation of 3-(pyridine-3-yl)-2-oxazolidinone derivatives as antibacterial agents, SDS of cas: 26820-62-2, the main research area is pyridinyl oxazolidinone preparation mol docking antibiofilm antibacterial activity; 3-(pyridine-3-yl)-2-oxazolidinone; antibacterial activity; biofilm formation inhibitory activity; drug resistance development; molecular docking.

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives I [R = (pyridin-3-yl)carbonyl, Me, N-cyclohexylcarbamoyl, etc.], II (X = F, H) was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphol., kinetic studies, and mol. docking. The results demonstrated that compounds II [R = cyclohexanecarbonyl, (2E)-3-(furan-2-yl)prop-2-enoyl (III), (2E)-3-(pyridin-3-yl)prop-2-enoyl, N-(4-chlorophenyl)carbamoyl; X = F] exhibited strong antibacterial activity similar to that of linezolid toward five Gram-pos. bacteria. After observing the effect of the drug on the morphol. and growth dynamics of the bacteria, the possible modes of action were predicted by mol. docking. Furthermore, the antibiofilm activity and the potential drug resistance assay were proceeded. These compounds exhibited universal antibiofilm activity and compound III showed significant concentration-dependent inhibition of biofilm formation. Compound III also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Antibacterial agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, SDS of cas: 26820-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khattab, Sherine N. published the artcileAminolysis of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine, Application of 4-(5-Nitropyridin-2-yl)morpholine, the main research area is hydroxybenzotriazole aminolysis reaction mechanism kinetics solvent effect.

The reaction 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with amines undergoes amination followed by elimination of the 1-hydroxyl benzotriazolyl anion. The kinetic data for the reaction of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with morpholine (Mo), cyclohexylamine (CHA) and aniline (An) in MeOH and acetonitrile (AN) proceeded by uncatalyzed mechanism in which the rate limiting step is the leaving group departure, whereas the reaction with Mo in toluene proceeded by uncatalyzed mechanism in which the formation of the zwitterionic intermediate is the rate determining step. While the reactions of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene with CHA and An and the reaction of 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with CHA in toluene proceeded by the specific base (SB) mechanism in which the rate determining step is the proton transfer process. The reactions of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with Mo in the three solvents and with CHA and An in MeOH and AN is greatly dependent on the stability of the zwitterionic intermediate. The effect of ring activation is due to the ground state stabilization and the more efficient delocalization of the neg. charge with a nitro group than with a ring-nitrogen in the transition state. The low activation enthalpies ΔH# and the highly neg. activation entropies ΔS# are due to the intramol. hydrogen bonding with the ammonio hydrogen present in the transition state.

Open Journal of Physical Chemistry published new progress about Activation enthalpy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Application of 4-(5-Nitropyridin-2-yl)morpholine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khattab, Sherine N. published the artcileSynthesis and aminolysis of 2,4-dinitrophenyl and 5-nitropyridine N-hydroxy oxime derivatives, Application In Synthesis of 26820-62-2, the main research area is aminolysis dinitrophenyl nitropyridine oxime morpholine nucleophilic aromatic substitution kinetics.

The 2,4-dinitrophenoxy derivatives 12-16 and the 5-nitro-2-pyridyloxy derivatives 18-22 were prepared The products were identified by elemental anal., IR, and NMR. The reaction of 12-16 and 18-22 with morpholine as nucleophile in CH3CN occurs through nucleophilic aromatic substitutions to give N-(2,4-dinitrophenyl)morpholine (23) and N-(5-nitro-2-pyridyl)morpholine (24) resp. Spectrophotometric measurements of the kinetics of these reactions in CH3CN at a range of temperatures indicated that they are not morpholine-catalyzed. The Bronsted-type plots for the reactions of 12-16 and 18-22 with morpholine are linear with slopes, β12-16 = -1.58 ± 0.1 and β18-22 = -1.15 ± 0.25 resp. The relative rate constants compared to the least reactive substrate, as well as the low neg. β values, supported that the decomposition of the zwitterionic intermediate is a slow process. The low activation parameters (ΔH# and ΔS#) are in accordance with the proposed transition state (T#). The expulsion of RO- anion in the rate-determining step is assisted by intramol. hydrogen-bonding with the ammonio-hydrogen present in the intermediate T#.

Bulletin of the Chemical Society of Japan published new progress about Activation enthalpy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Application In Synthesis of 26820-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gulevskaya, Anna V. published the artcileC-N bond formation by the oxidative alkylamination of azines: comparison of AgPy2MnO4 versus KMnO4 as oxidant, Formula: C9H11N3O3, the main research area is pyridine quinazoline amine oxidative alkylamination permanganate; aminopyridine preparation; aminoquinazoline preparation; permanganate oxidative alkylamination oxidant.

Reports on the successful oxidative alkylamination of azines by the SN-reaction, with the use of alkylamines other than methylamine, are very scarce. Hitherto, the exptl. limitation to extend oxidative amination of azines with NH3/KMnO4 to oxidative alkylamination is solely ascribed to the low solubility of KMnO4 in alkylamines and the increased sensitivity of alkylamines towards oxidation in comparison with ammonia. The exptl. data proved that there is also a substrate dependence in this type of reaction. 2-Alkylamino-5-nitropyridines and 4-alkylaminoquinazolines were smoothly obtained by the treatment of 3-nitropyridine and quinazoline, resp., with alkylamine/AgPy2MnO4. Although KMnO4 still gives moderate to good results with 3-nitropyridine, it is completely useless for reactions with quinazoline with the same alkylamines. The use of AgPy2MnO4 was found to give equal or superior results to those of KMnO4 depending on the alkylamine and the substrate used and therefore seems to be a promising general oxidant for successful oxidative alkylaminations.

European Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem