Category: 26820-62-2

Charushin, Valery N. published the artcilePyrimidines. Part 93. Ring transformations of heterocycles. Part 28. Ring transformations of 5-nitropyrimidine via inverse Diels-Alder reactions, Safety of 4-(5-Nitropyridin-2-yl)morpholine, the main research area is nitropyrimidine inverse Diels Alder ketene; nitropyridine; pyrimidine nitro Diels Alder ketene; enamine Diels Alder nitropyrimidine.

5-Nitropyrimidine (I) underwent inverse Diels-Alder cycloaddition reactions with ketene acetals and enamines to give pyridine derivatives Thus, reaction of I with morpholinocyclohexene in EtOH at 70° for 2 h gave 80% pyridine II. 1H NMR studies showed the reaction involves a bicyclic intermediate.

Tetrahedron Letters published new progress about Acetals, ketene Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Safety of 4-(5-Nitropyridin-2-yl)morpholine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Walsh, Katie published the artcileAmination of Heteroaryl Chlorides: Palladium Catalysis or SNAr in Green Solvents?, Product Details of C9H11N3O3, the main research area is pyrimidine pyrazine quinazoline preparation; heteroaryl chloride amine SNAr arylation water potassium fluoride; amination; aromatic substitution; green chemistry; nucleophilic substitution.

The reaction of heteroaryl chlorides in the pyrimidine, pyrazine and quinazoline series with amines in water in the presence of KF results in a facile SNAr reaction and N-arylation products, e. g., I. The reaction is less satisfactory with pyridines unless an addnl. electron-withdrawing group is present. The results showed that the transition-metal-free SNAr reaction not only compares favorably to palladium-catalyzed coupling reactions but also operates under environmentally acceptable (“”green””) conditions in terms of the base and solvent.

ChemSusChem published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Product Details of C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Chi-Yu published the artcileSynthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine, the main research area is phenoxybenzamide cycloaliphatic amine preparation human antiproliferative hedgehog signaling inhibitor.

A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety I (R1 = Me, OCF3, OMe, Cl; X = O, CH2), II (R2 = Ph, 3-MeOC6H4, 2-pyridyl, 3,4-Cl2C6H3, etc.) were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacol. data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound I (R1 = OCF3; X = O) showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of I (R1 = OCF3; X = O) showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.

Chinese Chemical Letters published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ding, Huaiwei published the artcileSynthesis and cytotoxic activity of some novel N-pyridinyl-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives, Formula: C9H11N3O3, the main research area is pyridine imidazothiazoleacetamide preparation antitumor.

Novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide (I) and were tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. 2-{6-(4-Chlorophenyl)imidazo[2,1-b]thiazol-3-yl}-N-{6-[4-(4-methoxybenzyl)piperazin-1-yl]pyridin-3-yl}acetamide, with slightly higher inhibition on VEGFR2 than I (5.72 and 3.76% inhibitory rate at 20 μM, resp.), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).

Molecules published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Chi-Yu published the artcileSynthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine, the main research area is phenoxybenzamide cycloaliphatic amine preparation human antiproliferative hedgehog signaling inhibitor.

A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety I (R1 = Me, OCF3, OMe, Cl; X = O, CH2), II (R2 = Ph, 3-MeOC6H4, 2-pyridyl, 3,4-Cl2C6H3, etc.) were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacol. data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound I (R1 = OCF3; X = O) showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of I (R1 = OCF3; X = O) showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.

Chinese Chemical Letters published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ding, Huaiwei published the artcileSynthesis and cytotoxic activity of some novel N-pyridinyl-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives, Formula: C9H11N3O3, the main research area is pyridine imidazothiazoleacetamide preparation antitumor.

Novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide (I) and were tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. 2-{6-(4-Chlorophenyl)imidazo[2,1-b]thiazol-3-yl}-N-{6-[4-(4-methoxybenzyl)piperazin-1-yl]pyridin-3-yl}acetamide, with slightly higher inhibition on VEGFR2 than I (5.72 and 3.76% inhibitory rate at 20 μM, resp.), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).

Molecules published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem