Category: 271-29-4

Related Products of 271-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.271-29-4, name is 1H-Pyrrolo[2,3-c]pyridine, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

1.1 7.0 g (106 mmol) of potassium hydroxide pellets are added to a solution of 5.00 g (42.3 mmol) of 1H-pyrrolo[2,3-c]pyridine in 80 ml of DMF, and a solution of 10.9 g (42.7 mmol) of iodine in 80 ml of DMF is added dropwise thereto at room temperature and with stirring and stirred for 45 minutes. A solution of 5 ml of 32% ammonia and 1 g of sodium disulfite in 1 l of water is added to the reaction mixture. The resultant precipitate is filtered off with suction, washed with water and dried in vacuo, giving 3-iodo-1H-pyrrolo-[2,3-c]pyridine as orange-yellow solid; ESI 245.

Statistics shows that 271-29-4 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-c]pyridine.

Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US2010/292262; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 271-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.271-29-4, name is 1H-Pyrrolo[2,3-c]pyridine, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

1.1 7.0 g (106 mmol) of potassium hydroxide pellets are added to a solution of 5.00 g (42.3 mmol) of 1H-pyrrolo[2,3-c]pyridine in 80 ml of DMF, and a solution of 10.9 g (42.7 mmol) of iodine in 80 ml of DMF is added dropwise thereto at room temperature and with stirring and stirred for 45 minutes. A solution of 5 ml of 32% ammonia and 1 g of sodium disulfite in 1 l of water is added to the reaction mixture. The resultant precipitate is filtered off with suction, washed with water and dried in vacuo, giving 3-iodo-1H-pyrrolo-[2,3-c]pyridine as orange-yellow solid; ESI 245.

Statistics shows that 271-29-4 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-c]pyridine.

Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US2010/292262; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 271-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.271-29-4, name is 1H-Pyrrolo[2,3-c]pyridine, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

To a solution of 1H-pyrrolo[2,3-c]pyridine (1 g, 8.47 mmol) in H2S04 (5 mL) was added 69% HNO3 (533 mg, 8.47 mmol) at 0 C. After stirred at 0 C for 2 hrs, the reaction mixture was allowed to warm to room temperature and stirred overnight. The mixture was then poured into H20 (100 mL) and basified by NaOH powder to pH> 7. Then the mixture was extracted by EA (100 mL x3), dried over anhydrous Na2SO4, and evaporated in vacuum to afford 3-nitro-1H- pyrrolo[2,3-c]pyridine (690 mg, 50%) as a yellow solid. ?H NIVIR (400 IVIHz, DMSO-d6): oe = 8.94 (s, 1H), 8.85 (s, 1H), 8.44 (d, J= 5.2 Hz, 1H), 8.02 (dd, J= 5.6, 1.2 Hz, 1H). MS: m/z 164.0 (M+H).

The chemical industry reduces the impact on the environment during synthesis 271-29-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 271-29-4, 1H-Pyrrolo[2,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 271-29-4, blongs to pyridine-derivatives compound. Product Details of 271-29-4

N-Iodosuccinimide (1.05 g, 4.66 mmol, 1.1 eq) was added to a solution of 6-azaindole (0.50 g, 4.24 mmol, 1.0 eq) in acetonitrile (25 mL). The reaction was stirred at room temperature for 1.5 hours before concentrating to remove the solvent. The residue was partitioned between EtOAc (100 mL) and Na2S2O3 (100 mL). The organics were washed with NaHCO3 (80 mL) and brine (80 mL), dried (Na2SO4) and concentrated under reduced pressure. MPLC (silica, 013% MeOH [2M NH3]-CH2Cl2) yielded 3-iodo-6-azaindole as a pink solid. To a solution of 3-iodo-6-azaindole (0.471 g, 1.93 mmol, 1.0 eq) in dimethylformamide (15 mL) at 0C was added sodium hydride (0.93 g of a 60% suspension in oil, 2.32 mmol, 1.2 eq). The reaction was stirred at 0C for 30 minutes and benzenesulfonyl chloride (0.30 mL, 2.32 mmol, 1.2 eq) added. The reaction was stirred between 0C and room temperature for 3 hours. The reaction was partitioned between EtOAc (80 mL) and NaHCO3-water (1:1, 80 mL). The organics were washed with brine (80 mL), water (80 mL) and brine (80 mL), dried (Na2SO4) and concentrated under reduced pressure. MPLC (silica, 4080% EtOAc-hexane) yielded 3-iodo-1-benzenesulfonyl-6-azaindole as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,271-29-4, its application will become more common.

Reference:
Article; Shaw, Simon J.; Goff, Dane A.; Lin, Nan; Singh, Rajinder; Li, Wei; McLaughlin, John; Baltgalvis, Kristen A.; Payan, Donald G.; Kinsella, Todd M.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 11; (2017); p. 2617 – 2621;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem