Category: 271-63-6

Synthetic Route of 271-63-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

a) 7-aza indole 100g (0.846mol), 12g Ni / Al2O3 (10% w.t), toluene 200g was added to the autoclave and stirred to obtain a reaction solution A;b) The autoclave was replaced with nitrogen 8 times, and hydrogen was replaced 4 times. Reaction liquid A was reacted at 2Mpa of hydrogen at a temperature of 130C.c) filtering the hydrogenation mixture obtained in step b), filtering out the catalyst to obtain a filtrate B;d) After recovering the organic solvent from the filtrate B, 94.59 g of the 7-azaporphyrin product was obtained, the yield was 93.4%, and the gas chromatographic purity of the product was ?98%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 271-63-6, 1H-Pyrrolo[2,3-b]pyridine.

Reference:
Patent; Zhonggang Group Anshan Heat Energy Institute Co., Ltd.; Wang Haiyang; Wang Shoukai; Xu Zhe; Zhao Wei; Jiang Hui; Jin Dan; Xu Haoran; (7 pag.)CN107987076; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

271-63-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

10.0 g (84.65 mmol) of 7-azaindole was suspended in 300 ml of CCl 4 and 4.35 mL (84.65 mmol) of Br 2 slowly at room temperatureAnd stirred for 12 hours under a stream of nitrogen. After completion of the reaction, the resulting solid was filtered,The reaction mixture was dissolved in loromethane and extracted with Na2S2O3. The organic solvent was removed and dried to obtain 12.0 g (yield: 72%) of the intermediate product (A)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 271-63-6, 1H-Pyrrolo[2,3-b]pyridine.

Reference:
Patent; Cheil Industries Co., Ltd.; Hong, Jin Suk; Yu, Dong Gyu; Yu, Uhn Sun; Lee, Han Ir; Kang, Dong Min; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; (31 pag.)KR2015/15252; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

271-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine, molecular formula is C7H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

PCC (45.7 g. 212 mmol) was compounded with silica gel (45.7 g. 100-200 mesh) and transferred to a 1 -L round-bottom flask containing DCE (400 mL). To the resulting orange suspension was added a solution of 1 -/-pyrrolo[2,3-b]pyridine (10.0 g, 84.7 mmol) in DCE (50 mL) and AICI3 (1 .5 g, 1 1 mmol). The mixture was stirred at 80C for 3 h, cooled to rt, filtered and the filter cake was washed with EA. The filtrate was concentrated and purified by FCC (PE:EA = 5: 1 ) to give compound P27a as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 271-63-6, 1H-Pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHENEX-FXR GMBH; GEGE, Christian; BIRKEL, Manfred; HAMBRUCH, Eva; DEUSCHLE, Ulrich; KREMOSER, Claus; (203 pag.)WO2019/16269; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 271-63-6 as follows., 271-63-6

A solution of 1H-pyrrolo[2,3-b]pyridine (1.0 g, 1 equiv.) in DMF (30 mL) at 0 C wastreated portionwise with NB S (1.51 g, 1 equiv.) under argon, and the resulting solution wasstirred at 0 C for 20 mm. The reaction mixture was allowed to warm to RT and stirring was continued for 10 mm. Then, the reaction mixture was transferred to a separatory funnel containing distilled water, and extracted with EtOAc (2×150 mL). Combined organic extracts were dried over Na2SO4, were filtered, and the solvent was removed invacuo. The crude product was recrystallized from DCM to afford the expected product (1.55 g). LCMS: IVIW (calc?d): 197.0; MS (ES, m/z): 197.3, 199.3 [M+H].

The chemical industry reduces the impact on the environment during synthesis 271-63-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; E-THERAPEUTICS PLC; KOLUND?IC, Filip; MILEK, Mateja; POLJAK, Tanja; RO?CIC, Maja; STUBBERFIELD, Colin; VADLAMUDI, Srinivasamurthy; (139 pag.)WO2019/43373; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below., 271-63-6

(1) Add 7-azaindole and water to the reactor, stir for 45 minutes, add tetramethyl phosphonium and MFI zeolite, heat to 50C, stir and mix, add formaldehyde,After homogenization, microwave irradiation was performed for 2 hours, and the reaction was continued for 6 hours after stirring. After filtration, the precipitate was dissolved in methylene chloride. After filtration, the filtrate was distilled under reduced pressure and recrystallized to give 7-azaindole-3-methanol.;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,271-63-6, 1H-Pyrrolo[2,3-b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Dongguan Lianzhou Knowledge Property Right Scheduled Operations Management Co., Ltd.; Chen Dongjin; (6 pag.)CN107903261; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-63-6, name is 1H-Pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. 271-63-6

General procedure: A solution of indole, azaindole or pyrrole (0.1 mmol) in dichloromethane (5 mL) was added to a suspension of 1:1 (W/W) ICl (concentration indicated in the Table; 0.1 mmol = 162 mg) and Celite (162 mg) ratio in dichloromethane (10 mL). The mixture was stirred at room temperature for the time indicated in Tables 1-4. The reaction mixture was then poured into saturated thiosulfate solution (20 mL) extracted with dichloromethane (2 x 15 mL). The organic layer was washed in brine and, dried over sodium sulfate and the solvent was removed at reduced pressure. The desired compound was purified by chromatography column using hexane and ethyl acetate mixtures as eluting solvent. Yields of iodinated compounds are summarized in Tables 1-4. All the compounds were characterized by IR, NMR and were compared with authentic samples.

Statistics shows that 271-63-6 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-b]pyridine.

Reference:
Article; Hamri, Salha; Rodriguez, Jose; Basset, Joan; Guillaumet, Gerald; Dolors Pujol; Tetrahedron; vol. 68; 31; (2012); p. 6269 – 6275;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem