Category: 271-73-8

Adding a certain compound to certain chemical reactions, such as: 271-73-8, 1H-Pyrazolo[3,4-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H5N3, blongs to pyridine-derivatives compound. Computed Properties of C6H5N3

To a solution of 1 H-pyrazolo[3,4-b]pyridine (I-6) (4 g, 34 mmol) in DMF (150 mL) was added KOH (7.6 g, 136 mmol) at 0 C. The mixture was stirred at room temperature for 30 min. To the resulting mixture was added iodine (15 g, 61 mmol) in portions at 0C and the mixture was stirred at room temperature overnight. TLC (petroleum ether/ EtOAc = 1 :1) showed the reaction was complete. The reaction mixture was poured into ice water and extracted with CH2CI2 (300 mL x 2). The combined organic layers were washed with sat. aq.Na2S03 (300 mL chi 2), brine (200 mL x 3), dried over Na2S04 and concentrated in vacuo to give 3-iodo-1 H-pyrazolo[3,4-b]pyridine (I-7) (7 g, 84%) as a yellow solid.

The synthetic route of 271-73-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 271-73-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 271-73-8, name is 1H-Pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A. 3-lodo-I H-pyrazolo[3,4-b]pyridineTo a solution of iH-pyrazolo[3,4-b]pyridine (2.00 g, i6.8 mmol) in DMF (35 mL) were added iodine (6.39 g, 25.2 mmol) and potassium hydroxide (2.35 g, 42.0 mmol). The reaction mixture was stirred at RT for i6 h. The mixture was diluted with iO% sodium thiosulfate and water and the resulting suspension was filtered to give the title compound as a yellow powder. TLC, R (EtOAc) = 0.8; MS (UPLCMS): 246.0 [M+H]+, 243.9 [M-H]-; tR (HPLC conditions f): i .3i mm.

According to the analysis of related databases, 271-73-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; RANDL, Stefan Andreas; VULPETTI, Anna; WO2014/2057; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem