Category: 27876-24-0

Relation of chemical constitution of some N-heterocyclic compounds to toxicity as fumigants was written by King, H. L.;Frear, D. E. H.. And the article was included in Journal of Economic Entomology in 1944.Product Details of 27876-24-0 This article mentions the following:

The following compounds were tested as fumigants in the laboratory against the confused flour beetle (Tribolium confusum): pyridine and these pyridine derivs: 2-Me-, 2-Et-, 2-Pr-, 2-iso-Pr-, 2-Bu-, 2-Am-, 2-hexyl- and isomers, 2-heptyl-, 2-octyl-, 2-(1-ethylhexyl)-, 2-(2-methyloctyl)-, 2-(1-amylhexyl)-, other 2-hendecyl isomers, 3-Me-, 4-Et-, 4-Pr-, 4-iso-Pr-, 4-Bu-, 4-Am-, 4-(3-pentyl)-, 4-hexyl- and isomers, 2,4-di-Me, 2,5-di-Me, 2,6-di-Me, 2-Et-6-Me-, 2-Bu-6-Me-, 2-Am-6-Me-, 2-hexyl-6-Me-, and 2-(hydroxyethyl)-. 2-Hexylpiperidine, 4-amylpiperidine and quinoline were included. The non-N compounds tested were CS₂, Me acetate, Et acetate, bis-2-chloroethyl ether, ethylene dichloride and CCl₄. Some of these compounds were also tested against the large milkweed bug (Oncopeltus fasciatus) and the red spider (Tetranychus telarius). Results: A pronounced peak of toxicity occurred in the 2-alkylpyridine series at the Pr or Bu derivatives Alkylpyridines with side chains in the 4-position were more toxic than 2-substituted isomers; compounds with normal side chains were usually more toxic than branched-chain isomers. The 2-alkylpiperidines tested were more toxic than the 2-alkylpyridines. The relative toxicities of the compounds tested on the red spider showed a strong correlation with their action on the 2 species of insects used in this investigation. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Product Details of 27876-24-0).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 27876-24-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and Utility of Dihydropyridine Boronic Esters was written by Panda, Santanu;Coffin, Aaron;Nguyen, Q. Nhu;Tantillo, Dean J.;Ready, Joseph M.. And the article was included in Angewandte Chemie, International Edition in 2016.Electric Literature of C11H17N This article mentions the following:

When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Electric Literature of C11H17N).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Electric Literature of C11H17N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics was written by Viswanadhan, Vellarkad N.;Ghose, Arup K.;Revankar, Ganapathi R.;Robins, Roland K.. And the article was included in Journal of Chemical Information and Computer Sciences in 1989.Safety of 4-Hexylpyridine This article mentions the following:

At. values for physicochem. properties are an important guide for correlating the observed biol. activity of the ligands to their chem. structure. The objective of the present work was to (i) report the hydrophobicity and the molar refractivity for P and Se atoms at different structural environments that are ubiquitous in biol. active systems, (ii) refine the at. values of the various elements reported earlier to satisfy the largely extended data set, and (iii) suggest a method for selecting the best superposition of different mols. on a reference structure using these at. physicochem. properties. The octanol-water partition coefficient was used to scale the at. hydrophobicity. The hydrophobicity values of 120 atom types were evaluated from 893 compounds The observed and calculated octanol-water partition coefficient showed a correlation coefficient of 0.926 and a standard deviation of 0.496. The at. refractivity values were evaluated from the molar refractivities of 538 compounds; the corresponding correlation coefficient and standard deviation were 0.999 and 0.774, resp. The at. values were tested by predicting the resp. properties for a large number of compounds The superposition methods was applied to certain naturally occurring nucleoside antibiotics. The algorithm presented showed various important superpositions of 閳? mols. with min. phys. assistance to avoid any personal bias. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Safety of 4-Hexylpyridine).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of 4-Hexylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A versatile synthesis of carboxypyridine betaines and their ¹H and ¹³C NMR spectra was written by Dega-Szafran, Zofia;Kowalczyk, Iwona;Szafran, Miroslaw. And the article was included in Bulletin of the Polish Academy of Sciences, Chemistry in 1996.Recommanded Product: 27876-24-0 This article mentions the following:

Pyridine betaine and 15 substituted betaines, I (R = 2-, 3-, 4-Me, 4-Et, 4-CMe₃, 3,4-Me₂, etc.), were prepared by alkylation of the corresponding R-substituted pyridines with Et chloroacetate. The ester group was removed by acid hydrolysis and the obtained hydrochlorides were subsequently reacted with propylene oxide in order to obtain pure, free R-pyridine betaines I. The ¹H and ¹³C NMR spectra of free betaines and their hydrochlorides were analyzed with respect to interaction of the ring substituents with the N⁺CH₂COO group. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Recommanded Product: 27876-24-0).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 27876-24-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Base-catalyzed reactions. XXXVII. Relative rates of side-chain alkenylation of 4-substituted pyridines with isoprene. Effects of the side-chain double bond on reaction rates was written by Stalick, Wayne M.;Pines, Herman. And the article was included in Journal of Organic Chemistry in 1970.Computed Properties of C11H17N This article mentions the following:

The competitive side-chain alkenylation of various 4-alkyl- and alkenylpyridines with isoprene catalyzed by alkali metals was investigated. Examination of the alkylpyridines used in the reaction shows that steric factors are important when substitution is made on the carbon 灏?to the pyridine ring. The presence of a side-chain double bond increases the rate of alkenylation and this is ascribed to a complexation of the olefinic bond with the alkali metal catalyst. The relative increase in competitive rate varies with the catalyst used in the reaction, such that K > na > Li. The changes in reactivity that occur when using different catalysts are explained by the hard and soft acids and bases (HSAB) principle. A table identifying many new 4-substituted pyridine compounds is also given. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Computed Properties of C11H17N).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C11H17N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Improved synthesis of 4-substituted pyridines from nitriles was written by Chelucci, Giorgio;Giacomelli, Giampaolo;Scano, Gianfranco. And the article was included in Gazzetta Chimica Italiana in 1991.Application In Synthesis of 4-Hexylpyridine This article mentions the following:

4-Substituted pyridines I ( R = n-hexyl, iso-Bu, sec-Bu, Ph) were prepared by a 4-step sequence in 23-27% overall yield starting from RCH₂CN. The synthesis involves alkylation of RCH₂CN with BrCH₂CH(OEt)₂, then with 2-iodomethyl-1,3-dioxolane, removal of the CN group and reaction of the glutaraldehyde acetals II, thus obtained, with NH₂OH.HCl in AcOH to give I. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Application In Synthesis of 4-Hexylpyridine).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 4-Hexylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Facile synthesis of 4-substituted pyridines using Grignard reagents was written by Akiba, Kinya;Iseki, Yuji;Wada, Makoto. And the article was included in Tetrahedron Letters in 1982.Quality Control of 4-Hexylpyridine This article mentions the following:

Reaction of N-(tert-butyldimethylsilyl)pyridinium triflate (I) with Grignard reagents gave 4-substituted 1,4-dihydropyridine derivatives with ≳99% regioselectivity; on oxidation with O these readily gave 4-substituted pyridines in 58-70% yield. E.g., treatment of I with BuMgBr in THF at room temperature under N for 2-3 h followed by bubbling O through the mixture gave 79% 4-butylpyridine. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Quality Control of 4-Hexylpyridine).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of 4-Hexylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alkylation of pyridine in free radical chain reactions utilizing alkylmercurials was written by Russell, Glen A.;Guo, Deliang;Khanna, Rajive K.. And the article was included in Journal of Organic Chemistry in 1985.HPLC of Formula: 27876-24-0 This article mentions the following:

Pyridines or N,N,N‘,N‘-tetramethyl-p-phenylenediamine will undergo a photostimulated free radical chain reaction with alkylmercury halides or carboxylates yielding ring alkylated substitution products. Alkene mercuration products can be used without isolation for the alkylation reaction. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0HPLC of Formula: 27876-24-0).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.HPLC of Formula: 27876-24-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Improved synthesis of 4-substituted pyridines from nitriles was written by Chelucci, Giorgio;Giacomelli, Giampaolo;Scano, Gianfranco. And the article was included in Gazzetta Chimica Italiana in 1991.Application In Synthesis of 4-Hexylpyridine This article mentions the following:

4-Substituted pyridines I ( R = n-hexyl, iso-Bu, sec-Bu, Ph) were prepared by a 4-step sequence in 23-27% overall yield starting from RCH₂CN. The synthesis involves alkylation of RCH₂CN with BrCH₂CH(OEt)₂, then with 2-iodomethyl-1,3-dioxolane, removal of the CN group and reaction of the glutaraldehyde acetals II, thus obtained, with NH₂OH.HCl in AcOH to give I. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Application In Synthesis of 4-Hexylpyridine).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 4-Hexylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem