Category: 28020-37-3

Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases was written by Levin, J. I.;Gu, Y.;Nelson, F. C.;Zask, A.;DiJoseph, J. F.;Sharr, M. A.;Sung, A.;Jin, G.;Cowling, R.;Chanda, P.;Cosmi, S.;Hsiao, C.-L.;Edris, W.;Wilhelm, J.;Killar, L. M.;Skotnicki, J. S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Synthetic Route of C7H10N2O2 This article mentions the following:

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analog I is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Synthetic Route of C7H10N2O2).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C7H10N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A simple one-pot synthesis of benzoxazine- 2,4-diones and benzothiazine-2,4-diones was written by Zhu, Xiaoxiang;Yu, Qian-Sheng;Greig, Nigel H.;Flippen-Anderson, Judith L.;Brossi, Arnold. And the article was included in Heterocycles in 2003.Application of 28020-37-3 This article mentions the following:

A simple and efficient procedure has been developed for a one-pot synthesis of substituted benzoxazine-2,4-diones and benzothiazine-2,4-diones directly from salicylic acid (or thiosalicylic acid) and amines. The reaction of [2-(chlorocarbonyl)phenyl]carbonic acid Me ester with 3,4-dimethoxybenzeneethanamine gave 2-(acetyloxy)-N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide. Deprotection of this gave 2-hydroxy-N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide and sequential cyclocondensation with carbonochloridic acid Et ester gave 3-[2-(3,4-dimethoxyphenyl)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione (I). A similar reaction sequence starting from 2-mercaptobenzoic acid gave 3-(phenylmethyl)-2H-1,3-benzothiazine-2,4(3H)-dione (II). In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Application of 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Molecular changes in particulate organic matter (POM) in a typical Chinese paddy soil under different long-term fertilizer treatments was written by Zhou, P.;Pan, G. X.;Spacclni, R.;Piccolo, A.. And the article was included in European Journal of Soil Science in 2010.SDS of cas: 28020-37-3 This article mentions the following:

A combination of solid-state CPMAS-¹³C-NMR and TMAH thermochemolysis-GC/MS was applied to investigate the mol. composition of particulate organic matter (POM) separated from a Chinese paddy soil, from the Tai Lake region, under a long-term field experiment with different fertilizer treatments. The treatments were: (i) no fertilizer application (NF), (ii) chem. fertilizers only (CF), (iii) chem. fertilizer plus pig manure (CFM) and (iv) chem. fertilizer plus crop straw (CFS). CPMAS-¹³C-NMR spectra showed that POM from all treated plots was rich in O-alkyl-C compounds, followed by alkyl-C and aromatic-C compounds However, as compared with a control (NF), POM under CFM and CFS treatments exhibited a smaller relative O-alkyl-C content and a larger contribution of aromatic-C and alkyl-C, thus increasing both aromaticity and hydrophobicity and, hence, recalcitrance of POM samples. Thermochemolysis of POM from all treatments demonstrated a dominance of aliphatic and lignin-derived compounds However, the distribution of lignin monomers (p-hydroxyphenyl, P, guaiacyl, G, and syringyl, S) revealed significant differences among the treatments. The relative distribution of lignin P, G and S monomers in NF, CF and CFS indicated a preferential contribution of annual crops and maize straw, as compared with that found for CFM. Concomitantly, a larger content of aliphatic thermochemolysis derivatives was found for CFS and CFM. The relative increase of aliphatic mols. in CFS was attributed to hydrophobic polyesters from higher plants. In the CF and CFM systems, the presence of aliphatic components of microbial origin suggested a greater microbial activity in comparison with NF and CFS. The combined application of solid state CPMAS-¹³C-NMR and TMAH thermochemolysis-GC/MS can be used to assess effectively the accumulation of recalcitrant organic compounds in soil POM under long-term fertilizer application with organic biomass. It is thus inferred that soil organic matter stabilization by mol. recalcitrance contributes to carbon sequestration in Chinese paddy soils under long-term managements. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3SDS of cas: 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases was written by Su, Xiangdong;Lawrence, Harshani;Ganeshapillai, Dharshini;Cruttenden, Adrian;Purohit, Atul;Reed, Michael J.;Vicker, Nigel;Potter, Barry V. L.. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Category: pyridine-derivatives This article mentions the following:

Extensive structural modifications to the 18β-glycyrrhetinic acid template are described and their effects on the SAR of the 11β-hydroxysteroid dehydrogenase isoenzymes type 1 and 2 from the rat are investigated. Isoform selective inhibitors have been discovered and N-(2-hydroxyethyl)-3β-hydroxy-11-oxo-18β-olean-12-en-30-oic acid amide is highlighted as a very potent selective inhibitor of 11β-hydroxysteroid dehydrogenase 2 with an IC₅₀ = 4 pM. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Category: pyridine-derivatives).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs was written by Harvey, Andrew J.;Avery, Thomas D.;Schaeffer, Laurent;Joseph, Christophe;Huff, Belinda C.;Singh, Rajinder;Morice, Christophe;Giethlen, Bruno;Grishin, Anton A.;Coles, Carolyn J.;Kolesik, Peter;Wagner, Stephanie;Andriambeloson, Emile;Huyard, Bertrand;Poiraud, Etienne;Paul, Dharam;O’Connor, Susan M.. And the article was included in ACS Medicinal Chemistry Letters in 2019.Reference of 28020-37-3 This article mentions the following:

Pos. allosteric modulators (PAMs) of α7 nAChRs can have different properties with respect to their effects on channel kinetics. Type I PAMs amplify peak channel response to acetylcholine but do not appear to influence channel desensitization kinetics, whereas Type II PAMs both increase channel response and delay receptor desensitization. Both Type I and Type II PAMs are reported in literature, but there are limited reports describing their structure-kinetic profile relationships. Here, we report a novel class of compounds with either Type I or Type II behavior that can be tuned by the relative stereochem. around the central cyclopropyl ring: for example, (R,R)-13 (BNC375) and its analogs with RR stereochem. around the central cyclopropyl ring are Type I PAMs, whereas compounds in the same series with SS stereochem. (e.g., (S,S)-13) are Type II PAMs as measured using patch-clamp electrophysiol. Further fine control over the kinetics has been achieved by changing the substitutions on the aniline ring: generally the substitution of aniline with strong electron withdrawing groups reduces the Type II character of these compounds Our structure-activity optimization efforts have led to the discovery of BNC375, a small mol. with good CNS-drug like properties and clin. candidate potential. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Reference of 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of propenamides with anti-malarial activities and 3D-QSAR study was written by Cheng, Maosheng;Yan, Dong;Wang, Qianli;Zhang, Li;Shen, Jianmin. And the article was included in Yaoxue Xuebao in 2003.Related Products of 28020-37-3 This article mentions the following:

The 3D-QSAR model of propenamides with anti-malarial activities was presented. The chem. synthesis combined with comparative mol. field anal. (CoMFA) was used. The QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6) were constructed. The activity of anti-W2 was depended mostly on steric interaction and the activity of anti-D6 was depended on both steric and electrostatic interaction. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Related Products of 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core was written by Dyck, Brian;Grigoriadis, Dimitri E.;Gross, Raymond S.;Guo, Zhiqiang;Marinkovic, Dragan;McCarthy, James R.;Moorjani, Manisha;Regan, Collin F.;Saunders, John;Schwaebe, Michael K.;Szabo, Tomas;Williams, John P.;Zhang, Xiaohu;Bozigian, Haig;Chen, Ta Kung. And the article was included in Journal of Medicinal Chemistry in 2005.Safety of 3-Amino-2,6-dimethoxypyridine This article mentions the following:

Two new classes of tricyclic-based corticotropin-releasing factor (CRF₁) receptor-1 antagonists were designed by constraining known 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine ligands. Pyrrole- and pyrazole-based mols. 19g and 22a, resp., were discovered that potently bind the recombinant CRF₁ receptor (K_i = 3.5, 2.9 nM) and inhibit adrenocorticotropic hormone (ACTH) release from rat pituitary cell culture (IC₅₀ = 14, 6.8 nM). These compounds show good oral bioavailability (F = 24%, 7.0%) and serum half-lives in rats (t_1/2 = 6.3, 12 h) and penetrate the rat brain ([brain]/[plasma] = 0.27, 0.52) but tend toward large volumes of distribution (V_D = 38, 44 L kg^-1) and rapid clearances (CL = 70, 43 mL min^-1 kg^-1). When given orally, both the pyrazole and the pyrrole leads dose-dependently inhibit stress-induced ACTH release in vivo. ACTH reductions of 84-86% were observed for 30 mg kg^-1 doses. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Safety of 3-Amino-2,6-dimethoxypyridine).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 3-Amino-2,6-dimethoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem