Sources of common compounds: 28733-43-9

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28733-43-9, 5-Bromonicotinamide.

Related Products of 28733-43-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28733-43-9, name is 5-Bromonicotinamide. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of methyltriphenylphosphonium bromide (2 97 g, 8 33 mmol) in THF {45 mL) at -78 C was added n-butylltthium (2.5 M in hexanes, 2 7 mL, 6 75 mmol) The resulting yellow reaction mixture was stirred for 30 min at -78 C. In a separate flask THF (9 mL) was added to 5-bromonicotiotanaldehyde (CASNo. 113118-81-3 , 837 mg, 4 5 mmol). The resulting 5-bromoniotacotiotanaldehyde solution was the transferred, via cannula, to the phosphonium ylide mixture followed by a 2 mL THF wash The reaction was allowed to warm to room temperature over 120 minutes and then permitted to stir for an additional 30 minutes The reaction was then quenched with saturated aqueous sodium bicarbonate and diluted with ethyl acetate The layers were separated and the organic layer was washed with saturated aqueous sodium bicarbonate The organic layer was concentrated to near dryness and the resulting residue was then diluted with ethyl acetate and 1 M sodium bisulfate and the layers were separated The organic layer was extracted two additional times with 1M sodium bisulfate. The aqueous layers were combined, diluted with dichloromethane, and neutralized via the careful addition of saturated aqueous sodium bicarbonate and solid sodium carbonate The layers were separated and the now basic aqueous layer was extracted three additional times with dichloromethane The dichloromethane layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated, The resulting residue was purified by silica gel flash chromatography (ethyl acetate-dichloromethane, 0 to 16%) to furnish 3-bromo-4- vinyl-pyndine, MS. (ES+) m/z 183.9 (M+H)’

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28733-43-9, 5-Bromonicotinamide.

Reference:
Patent; NOVARTIS AG; ADAMS, Christopher Michael; CHAMOIN, Sylvie; HU, Qi-Ying; ZHANG, Chun; WO2010/130794; (2010); A1;,
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