Category: 29681-39-8

Koay, Natalie; Tonelli, Devin L.; Truong, Vouy Linh published an article on January 5 ,2011. The article was titled 《Practical and efficient synthesis of N-fused tricyclic indoles》, and you may find the article in Tetrahedron Letters.Formula: C8H9NO3 The information in the text is summarized as follows:

A practical and efficient synthesis of Me 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate derivatives is reported. This synthetic approach featured the nucleophilic aromatic substitution of 2-piperidinemethanol derivatives with haloaryl fluorides, and the intramol. Heck coupling as key steps to afford the desired N-fused tricyclic indoles. After reading the article, we found that the author used Methyl 5-methoxypicolinate(cas: 29681-39-8Formula: C8H9NO3)

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C8H9NO3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Proximity effects in pyridines. Proton chemical shifts in substituted methyl pyridinecarboxylates》 was published in Organic Magnetic Resonance in 1975. These research results belong to Deady, L. W.; Harrison, P. M.; Topsom, R. D.. HPLC of Formula: 29681-39-8 The article mentions the following:

The chem. shifts in 6 series of substituted Me pyridinecarboxylates were measured and interpreted in terms of proximity effects. The shifts for ring H ortho and para to the substituent were explained by additive ester, nitrogen, and substituent effects. The results for meta H indicated substituent-nitrogen interactions, especially when both substituent and H were adjacent N. Similar results were obtained for the ester H. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-methoxypicolinate(cas: 29681-39-8HPLC of Formula: 29681-39-8)

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.HPLC of Formula: 29681-39-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 1971,Australian Journal of Chemistry included an article by Deady, L. W.; Shanks, R. A.; Campbell, Arthur Derek; Chooi, S. Y.. Related Products of 29681-39-8. The article was titled 《Synthesis of some substituted methyl pyridinecarboxylates. II. Methyl 4-substituted picolinates, methyl 5-substituted picolinates, and methyl 5-substituted nicotinates》. The information in the text is summarized as follows:

The preparation of substituted Me pyridinecarboxylates is described. Me 4-X-substituted picolinates and methyl 5-X-substituted picolinates (X = NO2, Br, MeO, Me2N) are prepared from 2-picoline via 4-nitro-2-picoline N-oxide and 2-amino-5-nitropyridine, resp. Me 5-X-substituted nicotinates (X = Br, MeO, Me2N) are prepared from 5-bromonicotinic acid. Preparations of Me 4-methylpicolinate and Me 5-methylnicotinate from the corresponding lutidines and Me 5-methylpicolinate from 2-amino-5-methylpyridine are described. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxypicolinate(cas: 29681-39-8Related Products of 29681-39-8)

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 29681-39-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Double Deprotonation of Pyridinols Generates Potent Organic Electron-Donor Initiators for Haloarene-Arene Coupling》 were Barham, Joshua P.; Coulthard, Graeme; Kane, Ryan G.; Delgado, Nathan; John, Matthew P.; Murphy, John A.. And the article was published in Angewandte Chemie, International Edition in 2016. Reference of Methyl 5-methoxypicolinate The author mentioned the following in the article:

Transition metal-free couplings of haloarenes with arenes, triggered using alkali metal alkoxides in the presence of an organic additive, are receiving significant attention in the literature. Most of the known organic additives effect coupling of iodoarenes, but not bromoarenes, to arenes. Recently it was reported that 2-pyridinecarbinol (11) extends the reaction to aryl bromides. This paper studies the mechanism, and reports evidence for dianions derived from 11 as electron donors to initiate the reaction. It also proposes routes by which electron-poor benzoyl derivatives can be transformed into electron donors to initiate these reactions. In addition to this study using Methyl 5-methoxypicolinate, there are many other studies that have used Methyl 5-methoxypicolinate(cas: 29681-39-8Reference of Methyl 5-methoxypicolinate) was used in this study.

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of Methyl 5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 1970,Journal of the Chemical Society [Section] B: Physical Organic included an article by Campbell, Arthur Derek; Chooi, S. Y.; Deady, L. W.; Shanks, R. A.. Safety of Methyl 5-methoxypicolinate. The article was titled 《Transmission of substituent effects of pyridines. I. Alkaline hydrolysis of some 3- and 4-substituted methyl pyridinecarboxylates》. The information in the text is summarized as follows:

The alk. hydrolysis of Me 5-(X-substituted)picolinates, Me 4-(X-substituted)picolinates, and Me 5-(X-substituted)nicotinates (X = NO2, Br, H, MeO, or Me2N) in methanol-water (85% wt/wt) is reported. In each series, the effect of the substituent and ring N are additive and the rates may be correlated with Hammett σm and σp values. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxypicolinate(cas: 29681-39-8Safety of Methyl 5-methoxypicolinate)

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of Methyl 5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C8H9NO3On November 30, 1998 ,《Additive effect of substituents and heterocyclic nitrogen on the alkaline hydrolysis rate of methyl esters of the substituted pyridinecarboxylic acids》 appeared in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). The author of the article were Sedova, V. F.; Skurko, O. P.. The article conveys some information:

Rate constants of alk. hydrolysis of Me esters in 6 series of substituted pyridinecarboxylates additively correlate with σ-constants of the N atom in the pyridine ring and of substituents, taking into account the transmission factors of their inductive and resonance effects.Methyl 5-methoxypicolinate(cas: 29681-39-8Formula: C8H9NO3) was used in this study.

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C8H9NO3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem