Category: 29681-42-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29681-42-3, name is Methyl 4-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 29681-42-3

Example 17, Compound 17; (E)-(1 S,14R,15R,18S,21 S)-21 -(3-Hydroxy-benzyl)-18-isopropyl-14-methoxy-15-methyl-3-oxa-6,17,20,23,27-pentaaza-tricyclo[21.3.1.1 *5,9*]octacosa- 5 7,9(28),10-tetraene-2,16,19,22-tetraone; Com ound 17a: (4-Bromo-pyridin-2-yl)-methanol.; Sodium borohydride (763 mg, 20.17 mmol) was added portionwise to a solution of 4- bromo-pyridine-2-carboxylic acid methyl ester (1 .98 g, 9.166 mmol) in ethanol (50 mL) under nitrogen and the reaction mixture was stirred at room temperature for 18 hours. The reaction was quenched by the addition of acetone (10 mL) and the reaction was stirred for 15 minutes. The solvent was evaporated and the residue partitioned between water and ethyl acetate. The aqueous layer was extracted with ethyl acetate and the combined organics were collected, dried over anhydrous sodium sulfate and the solvent evaporated to afford the title compound (1 .61 g, 94%) as a yellow oil. H NMR (300 MHz, CDCI3) 3.4-3.5 {br s, 1 H), 4.80 (s, 2H), 7.40 (dd, J = 5.4, 1 .8 Hz, 1 H), 7.50 (br m, 1 H), 8.39 (d, J = 5.4 Hz, 1 H). LCMS (m/z) 188/200 [M+H], Tr = 1 .55 min.

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Reference:
Patent; GILEAD SCIENCES, INC.; SELCIA LIMITED; APPLEBY, Todd; FLIRI, Hans, G.; KEATS, Andrew, J.; LAZARIDES, Linos; MACKMAN, Richard, L.; PETTIT, Simon, N.; POULLENNEC, Karine, G.; SANVOISIN, Jonathan; STEADMAN, Victoria, A.; WATT, Gregory, M.; WO2012/78915; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29681-42-3, name is Methyl 4-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 29681-42-3

Example 17, Compound 17; (E)-(1 S,14R,15R,18S,21 S)-21 -(3-Hydroxy-benzyl)-18-isopropyl-14-methoxy-15-methyl-3-oxa-6,17,20,23,27-pentaaza-tricyclo[21.3.1.1 *5,9*]octacosa- 5 7,9(28),10-tetraene-2,16,19,22-tetraone; Com ound 17a: (4-Bromo-pyridin-2-yl)-methanol.; Sodium borohydride (763 mg, 20.17 mmol) was added portionwise to a solution of 4- bromo-pyridine-2-carboxylic acid methyl ester (1 .98 g, 9.166 mmol) in ethanol (50 mL) under nitrogen and the reaction mixture was stirred at room temperature for 18 hours. The reaction was quenched by the addition of acetone (10 mL) and the reaction was stirred for 15 minutes. The solvent was evaporated and the residue partitioned between water and ethyl acetate. The aqueous layer was extracted with ethyl acetate and the combined organics were collected, dried over anhydrous sodium sulfate and the solvent evaporated to afford the title compound (1 .61 g, 94%) as a yellow oil. H NMR (300 MHz, CDCI3) 3.4-3.5 {br s, 1 H), 4.80 (s, 2H), 7.40 (dd, J = 5.4, 1 .8 Hz, 1 H), 7.50 (br m, 1 H), 8.39 (d, J = 5.4 Hz, 1 H). LCMS (m/z) 188/200 [M+H], Tr = 1 .55 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 29681-42-3, Methyl 4-bromopicolinate.

Reference:
Patent; GILEAD SCIENCES, INC.; SELCIA LIMITED; APPLEBY, Todd; FLIRI, Hans, G.; KEATS, Andrew, J.; LAZARIDES, Linos; MACKMAN, Richard, L.; PETTIT, Simon, N.; POULLENNEC, Karine, G.; SANVOISIN, Jonathan; STEADMAN, Victoria, A.; WATT, Gregory, M.; WO2012/78915; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29681-42-3, name is Methyl 4-bromopicolinate, molecular formula is C7H6BrNO2, molecular weight is 216.032, as common compound, the synthetic route is as follows.Application In Synthesis of Methyl 4-bromopicolinate

Step 1: 2-hydroxymethyl-4-bromopyridine Methyl 4-bromo-pyridine formate (990mg, 4.58mmol) and ethanol (250mL) were added to a 250mL reaction flask. Under stirring, sodium borohydride (380mg, 10mg) was slowly added to the reaction system in batches. The reaction mixture was stirred for 18 hours under the protection of nitrogen at room temperature. After completion of the reaction, 5mL acetone was added to the reaction system, followed by stirring for 15 minutes. The reaction solution was filtered, concentrated and added with ethyl acetate and water, and the layers were separated. The organic phase was dried and concentrated to obtain the title compound (yellow liquid, 760mg, 88%), the crude product was used directly for the subsequent reaction. (MS: [M+1] 187.9)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29681-42-3, Methyl 4-bromopicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Beijing Pearl Biotechnology Limited Liability Company; DONG, Jiaqiang; ZHONG, Boyu; YUAN, Hongbin; SHI, Quan; CHU, Shaosong; ZHANG, Deyi; ZHANG, Ruihao; (219 pag.)EP3150592; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29681-42-3, name is Methyl 4-bromopicolinate, molecular formula is C7H6BrNO2, molecular weight is 216.032, as common compound, the synthetic route is as follows.Application In Synthesis of Methyl 4-bromopicolinate

Step 1: 2-hydroxymethyl-4-bromopyridine Methyl 4-bromo-pyridine formate (990mg, 4.58mmol) and ethanol (250mL) were added to a 250mL reaction flask. Under stirring, sodium borohydride (380mg, 10mg) was slowly added to the reaction system in batches. The reaction mixture was stirred for 18 hours under the protection of nitrogen at room temperature. After completion of the reaction, 5mL acetone was added to the reaction system, followed by stirring for 15 minutes. The reaction solution was filtered, concentrated and added with ethyl acetate and water, and the layers were separated. The organic phase was dried and concentrated to obtain the title compound (yellow liquid, 760mg, 88%), the crude product was used directly for the subsequent reaction. (MS: [M+1] 187.9)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29681-42-3, Methyl 4-bromopicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Beijing Pearl Biotechnology Limited Liability Company; DONG, Jiaqiang; ZHONG, Boyu; YUAN, Hongbin; SHI, Quan; CHU, Shaosong; ZHANG, Deyi; ZHANG, Ruihao; (219 pag.)EP3150592; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem