Category: 29681-43-4

Related Products of 29681-43-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29681-43-4, name is Methyl 4-methoxypyridine-2-carboxylate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.

b) Lithium aluminum hydride (16 ml of a 1.0 N solution in diethyl ether, 16 mmol) was added to a solution of methyl 4-methoxypicoline-2-carboxylate (2.70 g, 16 mmol) in diethyl ether (50 ml) at ambient temperature. The reaction was stirred for 1 hour, poured into an aqueous solution of Rochelle’s salt (250 ml) and the reaction mixture extracted with ethyl acetate (3*50 ml). Purification of the crude product by flash chromatography on silica gel, eluding with dichloromethane-ethyl acetate, yielded 2-(hydroxymethyl)-4-methoxypyridine (800 mg, 36% yield) as a white solid.

The chemical industry reduces the impact on the environment during synthesis 29681-43-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AstraZeneca AB; US7081461; (2006); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 29681-43-4, Adding some certain compound to certain chemical reactions, such as: 29681-43-4, name is Methyl 4-methoxypyridine-2-carboxylate,molecular formula is C8H9NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29681-43-4.

A solution of lithium aluminium hydride (1M in diethyl ether, 16 ml) was added dropwise to a stirred mixture of methyl 4-methoxypyridine-2-carboxylate (2.7 g) and diethyl ether (50 ml). The resultant mixture was heated to reflux for 1 hour. The mixture was treated with potassium sodium tartrate tetrahydrate and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. The residue was purified by column chromatography using increasingly polar mixtures of methylene chloride and methanol as eluent to give 4-methoxypyrid-2-ylmethanol (0.8 g); NMR Spectrum: 3.62 (s, 3H), 4.51 (d, 2H), 5,34 (broad t, 1H), 6.8 (m, 1H), 6.99 (d, 1H), 8.27 (d, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29681-43-4, Methyl 4-methoxypyridine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zeneca Limited; US5821246; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem