Application of Methyl 5-methylnicotinate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29681-45-6, its application will become more common.

Reference of 29681-45-6 ,Some common heterocyclic compound, 29681-45-6, molecular formula is C8H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of methyl 5-methylnicotinate (5 g, 33 mmol) in carbon tetrachloride (200 mL) was added NBS (5.9 g, 1 equiv) and dibenzoyl peroxide (1.2 g, 0.15 equiv). The reaction was refluxed for 3 h, then was cooled to RT to give compound 14A. The carbon tetrachloride solution containing compound 14A was used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29681-45-6, its application will become more common.

Reference:
Patent; Li, James J,; Hamann, Lawrence G.; Ruan, Zheming; Cooper, Christopher B.; Wu, Shung C.; Simpkins, Ligaya M.; Wang, Haixia; Nayeem, Akbar; Krystek, Stanley R.; US2006/235028; (2006); A1;,
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