Category: 29682-15-3

In 2017,Odingo, Joshua; Bailey, Mai A.; Files, Megan; Early, Julie V.; Alling, Torey; Dennison, Devon; Bowman, Julie; Dalai, Suryakanta; Kumar, Naresh; Cramer, Jeffrey; Masquelin, Thierry; Hipskind, Philip A.; Parish, Tanya published 《In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis》.ACS Omega published the findings.Safety of Methyl 5-bromopicolinate The information in the text is summarized as follows:

Nitazoxanide has antiparasitic and antibiotic activities including activity against Mycobacterium tuberculosis. We prepared and evaluated a set of its analogs to determine the structure-activity relationship, and identified several amide- and urea-based analogs with low micromolar activity against M. tuberculosis in vitro. Pharmacokinetics in the rat suggested a path forward to obtain bioavailable compounds The series had a good microbiol. profile with bactericidal activity in vitro against replicating and nonreplicating M. tuberculosis. Analogs had limited activity against other Gram-pos. bacteria but no activity against Gram-neg. bacteria. Our studies identified the key liability in this series as cytotoxicity. Future work concentrating on identifying the target(s) could assist in removing activity against eukaryotic cells. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of α-Heteroaryl Propionic Esters by Palladium-Catalyzed α-Heteroarylation of Silyl Ketene Acetals》 was written by Li, Bowen; Luo, Bangke; Blakemore, Caroline A.; Smith, Aaron C.; Widlicka, Daniel W.; Berritt, Simon; Tang, Wenjun. Recommanded Product: Methyl 5-bromopicolinateThis research focused ontrimethylsiloxy propene tertiary butoxy heteroaryl bromide palladium catalyst heteroarylation; tertiary butyl pyridinyl propanoate preparation. The article conveys some information:

A practical and efficient synthesis of α-heteroaryl propionic esters was developed by employing palladium-catalyzed α-heteroarylation of silyl ketene acetals, forming a wide variety of α-heteroaryl propionic esters with various substituents and functionalities in high yields. The success of this transformation was credited to the development of the bulky P,P=O ligand. This method provided an efficient synthesis of α-heteroaryl propionic acids. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Maoqiu; Yu, Junting; Liu, Denghui; Tan, Shuai; Yang, Xiaoqin; Cao, Liqin; Tan, Yuna; Cao, Jiamin; Tan, Hua; Wang, Yafei; Zhu, Weiguo published an article in 2021. The article was titled 《Enhancing the efficiency of near-infrared iridium (III) complexes-based OLEDs by auxiliary ligand functionalizationã€? and you may find the article in Synthetic Metals.SDS of cas: 29682-15-3 The information in the text is summarized as follows:

In order to enhance the charge balance of organic near IR (NIR) electroluminescent devices, an ancillary ligand of pic-SCz which was covalently linking the bipolar group SCz (composed of PS (S) and tBuCz (Cz)) to pic (SCz=3,6-di-tert-butyl-9-(4-(phenylsulfonyl)phenyl)-9H-carbazole; PS = Ph sulfone; tBuCz = 3,6-di-tert-butylcarbazole; pic= 2-picolinic acid) was developed for iridium (III) complex (TPA-BTz-Iq)2Ir(pic-SCz). Compared with parent complex (TPA-BTz-Iq)2Irpic, the photophys. and electroluminescent properties of (TPA-BTz-Iq)2Ir(pic-SCz) were improved by introducing Cz as hole transporting unit and PS as electron transporting unit. In phosphorescent organic light emitting devices (OLEDs), using (TPA-BTz-Iq)2Ir(pic-SCz) as the luminescent dopant, we obtained a maximum external quantum efficiency (EQEmax) of 0.95% at the wavelength of 712 nm. This is 3.28 times as much as that of (TPA-BTz-Iq)2Irpic (EQEmax is 0.29% at 712 nm). The experimental part of the paper was very detailed, including the reaction process of Methyl 5-bromopicolinate(cas: 29682-15-3SDS of cas: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.SDS of cas: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of Methyl 5-bromopicolinateIn 2005 ,《Ligand creation via linking – a rapid and convenient method for construction of novel supported PyOX-ligandsã€?appeared in Tetrahedron. The author of the article were Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M. P.. The article conveys some information:

A novel, tyrosine-derived, supported amino alc. linker was synthesized and used for attachment of picolinic acid derivatives onto different supports. When the resin bound mol. was further activated, the PyOX-moiety could be constructed reliably in enantiopure form. Furthermore, an efficient Pd-catalyzed modification of a picolinic acid derivative is presented. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and optoelectronic properties of novel fluorene-bridged dinuclear cyclometalated iridium (III) complex with A-D-A framework in the single-emissive-layer WOLEDsã€?was written by He, Keqi; Wang, Xiangdong; Yu, Junting; Jiang, Haigang; Xie, Guangshan; Tan, Hua; Liu, Yu; Ma, Dongge; Wang, Yafei; Zhu, Weiguo. Product Details of 29682-15-3This research focused onWOLED SEL framework fluorine bridged dinuclear cyclometalated iridium complex; complex optoelectronic property Suzuki coupling reaction. The article conveys some information:

To explore the influence of push-pull chromophores on properties of emitter in organic light-emitting devices (OLEDs), an acceptor-donor-acceptor (A-D-A)-based dinuclear iridium (III) complex of (dfppy)4Ir2(dipic-FL) was synthesized via Suzuki coupling reaction, in which dfppy is 2-(2,4-difluorophenyl)pyridine and dipic-FL is 2,7-di(5-pyridyl-2-carboxyl)-9,9-dioctyl-9H-fluorene. An intense emission peak at about 480 nm resulting from the (dfppy)2Ir(pic) chromophore and a weak long-wavelength emission band at 580-660 nm attributed to intramol. charge transfer transition were exhibited for (dfppy)4Ir2(dipic-FL) in dichloromethane solution But a remarkably hypsochromic photoluminescence profile with an intense characteristic emission peak at 422 nm was observed, which is attributed to the intraligand (IL) π-π* excited states in its thin film. White emission with a maximum luminance of 1040 cd/m2 and current efficiency of 1.2 cd/A was obtained in its single-emissive-layer (SEL) OLEDs with a configuration of ITO/PEDOT:PSS/(dfppy)4Ir2(dipic-FL) (10 wt%):TCTA/TPBi/LiF/Al. To our knowledge, this is one of the best examples in term of dinuclear iridium complex as single dopant in the high-performance white-emitting SEL-OLEDs.Methyl 5-bromopicolinate(cas: 29682-15-3Product Details of 29682-15-3) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of Methyl 5-bromopicolinateIn 2021 ,《Synthesis and characterization of new pyridine-based chiral calamitic liquid crystals》 appeared in Liquid Crystals. The author of the article were Vardar, Deniz; Ocak, Hale; Akdas Kilic, Huriye; Jeannin, Olivier; Camerel, Franck; Eran, Belkiz Bilgin. The article conveys some information:

In this paper, novel chiral calamitic compounds, consisting of n-dodecyloxyphenyl substituted pyridine carboxylate core linked to one or two benzene rings through ester linkers was synthesized by multi-step procedures. The other end was varied by introducing a flexible (S)-2-methylbutyloxy or (S)-3,7-dimethyloctyloxy chiral chain. The liquid crystal properties of new compounds were investigated by various exptl. techniques such as DSC, POM and SAXS. The pyridine-based calamitic compounds exhibited enantiotropic chiral smectic mesophases such as SmC*, SmA or uncharacteristic mesophase depending on hetero aromatic rings such as nicotinate or picolinate cores, number of aromatic rings and the type of chiral-branched chain. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Reference of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2017 ,《Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors》 was published in ChemMedChem. The article was written by Wuensch, Matthias; Senger, Johanna; Schultheisz, Philipp; Schwarzbich, Sabrina; Schmidtkunz, Karin; Michalek, Carmela; Klass, Michaela; Goskowitz, Stefanie; Borchert, Philipp; Praetorius, Lucas; Sippl, Wolfgang; Jung, Manfred; Sewald, Norbert. The article contains the following contents:

As histone deacetylases (HDACs) play an important role in the treatment of cancer, their selective inhibition has been the subject of various studies. These continuous investigations have given rise to a large collection of pan- and selective HDAC inhibitors, containing diverse US Food and Drug Administration (FDA)-approved representatives. In previous studies, a class of alkyne-based HDAC inhibitors was presented. We modified this scaffold in two previously neglected regions and compared their cytotoxicity and affinity toward HDAC1, HDAC6, and HDAC8. We were able to show that R-configured propargylamines contribute to increased selectivity for HDAC6. Docking studies on available HDAC crystal structures were carried out to rationalize the observed selectivity of the compounds Substitution of the aromatic portion by a thiophene derivative results in high affinity and low cytotoxicity, indicating an improved drug tolerance. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2008,Martin, Thibaut; Verrier, Cecile; Hoarau, Christophe; Marsais, Francis published 《Direct C-2 arylation of alkyl 4-thiazolecarboxylates: new insights in synthesis of heterocyclic core of thiopeptide antibiotics》.Organic Letters published the findings.Application of 29682-15-3 The information in the text is summarized as follows:

The Pd(0)-catalyzed regioselective C-2 (hetero)arylation of tert-Bu 4-thiazolecarboxylate with a broad (hetero)aryl halide is reported, including the direct coupling of pyridinyl halides. The process has allowed the preparation of valuable 2-pyridynyl-4-thiazolecarboxylates which are components of the complex heterocyclic core of thiopeptides antibiotics. As a first application, a synthesis of a tert-Bu sulfomycinamate thio-analog from tert-Bu 4-thiazolecarboxylate is here described through a three-step direct pyridinylation, halogenation, and Stille cross-coupling sequence.Methyl 5-bromopicolinate(cas: 29682-15-3Application of 29682-15-3) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2009,Xiao, Fangliang; Liu, Yu; Hu, Zhengyong; Gan, Quan; Wang, Lei; Wen, Zhonglin; Zhu, Meixiang; Zhu, Weiguo published 《Synthesis of bicyclometalated iridium complex containing 1,3,4-oxadiazole-based picolinic acid derivative and its optoelectronic properties in polymer light-emitting devices》.Synthetic Metals published the findings.Formula: C7H6BrNO2 The information in the text is summarized as follows:

A picolinic acid (Pic) derivative I bearing a 1,3,4-oxadiazole unit and its bicyclometalated iridium complex (PhOXD)2Ir(BuPhOXD-Pic) were synthesized and characterized, in which BuPhOXD-Pic (I) is 5-(4′-(5”-(4-tert-butylphenyl)-1”,3”,4”-oxadiazol-2”-yl) phenyl) picolinic acid and PhOXD is 2,5-diphenyl-1,3,4-oxadiazole. The optoelectronic properties of this iridium complex were studied in the double-layer polymer light-emitting devices using a blend of poly (9,9-dioctylfluorene) and 5-biphenyl-2-(4-tert-butyl) phenyl-1,3,4-oxadiazole as a host matrix. This complex exhibited a maximum luminance efficiency of 7.7 cd/A at 5.6 mA/cm2 and a peak brightness of 5288 cd/m2 at 153.7 mA/cm2 in the devices. Compared to the (PhOXD)2Ir(Pic) complex, the (PhOXD)2Ir(BuPhOXD-Pic) complex displays better optoelectronic properties in the devices. This study provides a convenient way to improve the optoelectronic properties of iridium complexes by modifying an ancillary ligand of picolinic acid with an 1,3,4-oxadiazole unit. The experimental process involved the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Methyl 5-bromopicolinateIn 2012 ,《Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I》 appeared in Organic Letters. The author of the article were Tsukano, Chihiro; Oimura, Atsuko; Enkhtaivan, Iderbat; Takemoto, Yoshiji. The article conveys some information:

A new strategy for synthesizing quinolizidine skeletons by reductive cyclization via acylpyridinium cations was developed. Several functional groups, including carbonyl, silyl, and acetal, were tolerated under mild reaction conditions. For example, reacting the acylpyridinium cations derived from I (R = Me, Ph, Br, CF3) with Ghosez’s reagent and Hantzch ester in the presence of 4Å mol. sieves gave quinolizidines II. The reaction was successfully extended to a one-pot synthesis of a bicyclic compound, and the synthetic strategy was applied to concise total syntheses of quinolizidines 207I and 1-epi-207I, without protecting groups. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem